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http://dx.doi.org/10.15429/jkomor.2016.16.2.124

Understanding of Medical Cannabis and its Regulations: A Suggestion for Medical and Scientific Needs  

Han, Kyungsun (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongguk University)
Lee, Myeong-Jong (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongguk University)
Kim, Hojun (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongguk University)
Publication Information
Journal of Korean Medicine for Obesity Research / v.16, no.2, 2016 , pp. 124-132 More about this Journal
Abstract
In traditional medicine, Cannabis sativa L. has been used for variety of reasons. Old literatures delineate that Cannabis had been used as anesthetic and analgesic, or to reduce symptoms such as cough, paralysis and so on. Although Cannabis has a long history of medical use, it is illegal in many countries including South Korea. Controversy over decriminalization of Cannabis to allow cannabis for therapeutic use has been around for many years. In order to understand current knowledge on the therapeutic use of medical Cannabis, comprehension of cannabinoids and other constituents of Cannabis is important. Here we reviewed the pharmacological effect of Cannabis and current mandatory regulation over Cannabis in many countries to suggest necessity of research on medical Cannabis.
Keywords
Cannabis; Cannabis sativa; Medical cannabis; Medical marijuana;
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  • Reference
1 Hillig KW. Genetic evidence for speciation in Cannabis (Cannabaceae). Genet Resour Crop Evol. 2005 ; 52(2) : 161-80.   DOI
2 Pain S. Cannabis: a potted history. Nature. 2015 ; 525(7570) : S10-1.   DOI
3 Committee of Korean Medicine Textbook Compilation. Galenic pharmacology. Seoul : Younglimsa. 2006 : 291-2.
4 Korea National Arboretum [Internet]. Pocheon: Korea National Arboretum; 2014 [cited 2016 Nov 4]. Available from: www.nature.go.kr.
5 Heo J. Principles and practice of eastern medicine; donguibogam. Seoul : Donguibogam Publishing Company. 1994.
6 Andre CM, Hausman JF, Guerriero G. Cannabis sativa: the plant of the thousand and one molecules. Front Pland Sci. 2016 ; 7 : 19.
7 Todd AR. Chemistry of the hemp drugs. Nature. 1940 ; 146 : 829-30.   DOI
8 Adams R, Loewe S, Jelinek C, Wolff H. Tetrahydrocannabinol homologs with marihuana activity. J Am Chem Soc. 1941 ; 63(7) : 1971-3.   DOI
9 Pertwee RG. Cannabinoid pharmacology: the first 66 years. Br J Pharmacol. 2006 ; 147(S1) : 163-71.
10 Kalant H. Medical use of cannabis: history and current status. Pain Res Manag. 2001 ; 6(2) : 80-91.   DOI
11 Devane WA, Dysarz FA, Johnson MR, Melvin LS, Howlett AC. Determination and characterization of cannabinoid receptor in rat rain. Mol Pharmacol. 1988 ; 34(5) : 605-13.
12 Devane WA, Hanus L, Breuner A, Pertwee RG, Stevenson LA, Griffin G, et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. 1992 ; 258(5090) : 1946-9.   DOI
13 Di Marzo V, Piscitelli F. The endocannabinoid system and its modulation by phytocannabinoids. Neurotherapeutics. 2015 ; 12(4) : 692-8.   DOI
14 Felder CC, Joyce KE, Briley EM, Mansouri J, Mackie K, Blond O, et al. Comparison of the Paharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptor. Mol Pharmacol. 1995 ; 48(3) : 443-50.
15 Choe S, Yang W, Park Y, Choi H, Chung H. Classification of Cannabis sativa L. by the contents of cannabinoids and the characteristics of stable isotope. Seoul : The Pharmaceutical Society of Korea. 2011 : 264.
16 Englund AM, Stone J, Morrison PD. Cannabis in the arm: what can we learn from intravenous cannabinoid studies? Curr Pharmaceut Des. 2012; 18(32) : 4906-14.   DOI
17 Werz O, Seegers J, Schaible AM, Weinigel C, Barz D, Koeberle A, et al. Cannflavins from hemp sprouts, a novel cannabinoid-free hemp food product, target microsomal prostaglandin-E2 synthase-1 and 5-lipoxygenase. Pharmanutr. 2014 ; 2(3) : 53-60.   DOI
18 Burstein S. Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorgan Med Chem. 2015 ; 23(7) : 1377-85.   DOI
19 Russo EB, Burnett A, Hall B, Parker KK. Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res. 2005 ; 30(8): 1037-43.   DOI
20 Siger A, Nogala-Kalucka M, Lampart-Szczapa E. The content and antioxidant activity of phenolic compounds in cold-pressed plant oils. J Food Lipids. 2008 ; 15(2) : 137-49.   DOI
21 Fischedick JT, Hazekamp A, Erkelens T, Choi YH, Verpoorte R. Metabolic fingerprinting of Cannabis sativa L., cannabinoids and terpeenoids for chemotaxonomic and drug stardardization purposes, Phytochemistry. 2010 ; 71(17) : 2058-73.   DOI
22 Philipsen N, Butler RD. Medical marijuana: a primer on ehtics, evidence, and politics. J Nurse Pract. 2014 ; 10(9) : 633-40.   DOI
23 Weiss SR. The state of the science on the therapeutic potential of marijuana and Cannabinoids [Internet]. Bethesda, MD: National Institute of Drug Abuse; 2016 [cited 2016 Nov 8]. Avilable from: https://www.judiciary.senate.gov/imo/media/doc/07-13-16%20Weiss%20Testimony.pdf.
24 Walsh Z, Callaway R, Belle-Isle L, Capler R, Kay R, Lucas P, et al. Cannabis for therapeutic purposes: patient characteristics, access, and reasons for use. Int J Drug Policy. 2013 ; 24(6) : 511-6.   DOI
25 Reinarman C, Nunberg H, Lanthier F, Heddleston T. Who are medical marijuana patients? Population characteristics from nine California assessment clinics. J Psychoact Drugs. 2011 ; 43(2) : 128-35.   DOI
26 Tuyp BJ. The adverse health effects of persistent cannabis use: Review & recommendations for change. UBC Med J. 2013 : 5(1) ; 24-9.
27 Amar MB. Cannabinoids in medicine: a review of their therapeutic potential. J Ethnopharmacol. 2006 ; 105(1) : 1-25.   DOI
28 van Amsterdam J, Brunt T, van den Brink W. The adverse health effects of synthetic cannabionoids with emphasis on psychosis-like effects. J Psychopharmacol. 2015 ; 29(3) : 254-63.   DOI
29 Crean RD, Crane NA, Mason BJ. An evidence-based review of acute and long-term effects of cannabis use on executive cognitive functions. J Addict Med. 2011 ; 5(10) : 1-8.   DOI
30 Hall W. What has research over the past two decades revealed about the adverse health effects of recreational cannabis use? Addiction. 2014 ; 110(1) : 19-35.   DOI
31 Lichtman A, Martin B. Cannabinoid tolerance and dependence. Handb Exp Pharmacol. 2005 ; 168 : 691-717.
32 Hirvonen J, Goodwin RS, Li CT, Terry GE, Zoghbi SS, Morse C, et al. Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. Mol Psychiatry. 2012 ; 17(6) : 642-9.   DOI
33 Budney A, Hughes J. The cannabis withdrawal syndrome. Curr Opin Psychiatry. 2006 ; 19(3) : 233-8.   DOI
34 Rubino T, Parolaro D. The impact of exposure to cannabinoids in adolescence: insights from animal models. Biol Psychiatry. 2016 ; 79(7) : 578-85.   DOI
35 Korea Ministry of Government Legislation [Internet]. Sejong: Korea Ministry of Government Legislation; [cited 2016 Nov 8]. Available from: http://www.law.go.kr/lsInfoP.do?lsiSeq=180797&ancYd=20160203&efYd=20160203&ancNo=14019#0000.
36 Kennedy B. How Israel has become global leader in cannabis research [Internet]. Denver, CO: The Cannabist; [cited 2016 Nov 8]. Available from: http://www.thecannabist.co/2016/09/28/israel-cannabis-research/63987/.
37 Choi S. Policy of reaction regarding Cannabis. Korean Assoc Policy Studies Autumn Meet. 2014 ; 29 : 45.
38 Lee CK. The constituents of Korean Cannabis. J Pharm Soc Korea. 1973 ; 17 : 21-6.
39 Moon YH, Lee BH, Jeong BC, Kim YU, Kim GY. Breeding history of non-drug type hemp variety "Cheungsam" and it's characteristics. Korean J Intl Agri. 2002 ; 14(2) : 119-26.
40 Hoffmann DE, Weber E. Medical marijuana and the law. N Engl J Med. 2010 ; 362(16) : 1453-57.   DOI
41 Bifulco M, Pisanti S. Medical use of cannabis in europe. EMBO Rep. 2015 ; 16(2) : 130-2.   DOI
42 Spithoff S, Emerson B, Spithoff A. Cannabis legalization: adhering to public health best practice. CMAJ. 2015 ; 187(16) : 1211-6.   DOI
43 De Petroclellis L, Ligresti A, Moriello AS, Allara M, Bisogno T, Petrosino S. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. Br J Pharmacol. 2011 ; 163(7) : 1479-94.   DOI
44 Englund AM, Stone J, Morrison PD. Cannabis in the arm: what can we learn from intravenous cannabinoid studies? Curr Pharmacetu Des. 2012 ; 18(32) : 4906-14.   DOI
45 Wagner H, Ultrich-Merzenich G. Syndergy research: appreoaching a new generation of phytopharmaceuticals. Phytomedicine. 2009 ; 16(2) : 97-110.   DOI
46 Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effect. Br J Pharmacol. 2011 ; 163(7) : 1344-64.   DOI
47 Mehra R, Moore BA, Crothers K, Tetrault J, Fiellin DA. The association between marijuana smoking and lung cancer: a systematic review. Arch Intern Med. 2006 ; 166(13) : 1359-67.   DOI
48 Gieringer DH. Cannabis "Vaporization" a promising strategy for smoke harm reduction. J Cannabis Ther. 2001 ; 1(3-4) : 153-70.   DOI
49 Perez J. Combined cannabinoid therapy via an oromucosal spray. Drugs Today. 2006 ; 42(8) : 495-503.   DOI
50 Politi M, Peschel W, Wilson N, Zloh M, Prieto JM, Heinrich M. Direct NMR analysis of cannabis water extracts and tinctures and semi-quantitative data on ${\Delta}$ 9-THC and ${\Delta}$ 9-THC-acid. Phytochemistry. 2008 ; 69(2) : 562-70.   DOI
51 Charavarty I, Sengupta D, Bhattacharyya P, Ghosh JJ. Effect of treatment with cannabis extract on the water and glycogen contents of the uterus in normal and estradiol-treated prepubertal rats. Toxicol Appl pharmacol. 1975 ; 34(3) : 513-6.   DOI