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http://dx.doi.org/10.14374/HFS.2022.30.4.225

Eriobotrya japonica inhibits the transactivation of nuclear orphan receptor : the possibility to treat the chronic diseases  

Min-Jin, Kim (School of Korean Medicine, Dongguk University)
Young Woo, Kim (School of Korean Medicine, Dongguk University)
Sun-Dong, Park (School of Korean Medicine, Dongguk University)
Publication Information
Herbal Formula Science / v.30, no.4, 2022 , pp. 225-231 More about this Journal
Abstract
Objectives : Oxidative damage has a variety of mechanism in the human organs including brain and liver. The purpose of this study is to examine the prevention against cellular damage, and the inhibitory effect on lipogenesis of the water extract of Eriobotrya japonica (EJE). Methods : The effect of EJE on cell viability was assessed using the MTT assay. To investigate the mechanism of EJE's inhibition of lipogenesis, we analyzed the relevant proteins using immunoblot analysis. Results : Induction of T0901317, a LXR agonist, significantly increased SREBP-1c expression, which was blocked by the pretreatment of EJE in the dose-dependent manners. This beneficial herb also regulated the genes related with SREBP-1c such as the acetyl-CoA carboxylase. Conclusion : These results suggested that EJE might have a possibility of the treatment of chronic diseases as mediated with the inhibition of LXRα/SREBP-1c pathway.
Keywords
Eriobotrya japonica; SREBP-1c; $LXR{\alpha}$; Chronic disease;
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Times Cited By KSCI : 4  (Citation Analysis)
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