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http://dx.doi.org/10.14374/HFS.2020.28.2.189

Herbal formula MJY2018 protects against Alcohol-induced liver injury mice model  

Kim, Kwang-Youn (Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM))
Park, Kwang-Il (Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM))
Cho, Won-Kyung (Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM))
Yang, Ju-Hye (Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM))
Ma, Jin-Yeul (Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM))
Publication Information
Herbal Formula Science / v.28, no.2, 2020 , pp. 189-198 More about this Journal
Abstract
Objectives : This study investigated the liver-protective effects of MJY2018, a Herbal formula, against alcoholic fatty liver disease and anti-oxidative effects. Methods : Its effects were investigated in an alcoholic fatty liver disease model in male C57BL/6 mice, which were fed Lieber-DeCarli liquid diet containing ethanol. MJY2018 (100 and 200 mg/kg bw/day) or silymarin (50 mg/kg bw/day) were orally administered daily in the alcoholic fatty liver disease mice for 16 days. Results : The results indicate that MJY2018 promotes hepatoprotection by significantly reducing aspartate transaminase (AST) and alanine transaminase (ALT) levels as indicators of liver damage in the serum. Furthermore, MJY2018 reduced accumulation of triglyceride and total cholesterol, increased levels of superoxide dismutase (SOD) and glutathione (GSH) in the livers of the alcoholic fatty liver disease mice model. Additionally, it improved the serum alcohol dehydrogenase (ADH) activity. Conclusions : These results indicate that MJY2018 were effective in improving and protecting oxidative stress and alcoholic liver disease.
Keywords
herbal formula; MJY2018; alcohol; liver damage; antioxidant;
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Times Cited By KSCI : 3  (Citation Analysis)
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1 Chayanupatkul M, Liangpunsakul S, Alcoholic hepatitis: a comprehensive review of pathogenesis and treatment. World Journal of Gastroenterology, 2014;20(20):6279-86.   DOI
2 Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, et al., Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver. Gastroenterology, 2014;146(3):801-11.   DOI
3 Wheeler MD, Nakagami M, Bradford BU, Uesugi T, Mason RP, Connor HD, et al., Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. Jouranl of Bioligical Chemistry, 2001;276:36664-72.   DOI
4 Lu SC, Mato JM, S-Adenosylmethionine in cell growth, apoptosis and liver cancer. Journal of Gastroenterology and Hepatology, 2008;23:s73-s77.   DOI
5 LEE SJ, Kang MJ, Shin JH, Kim JG, Kang SK, Sung NJ, The Effect of Garlic and Medicinal Plants Extracts on the Liver Function and Lipid Metabolism of Rats Administered with Alcohol. Journal of the Korean Society of Food Science and Nutrition, 2009;38(5);561-8.   DOI
6 Ko BS, Jang JS, Hong SM, Kim DW, Sung SR, Park HR, et al., Effect of new remedies mainly comprised of Hovenia dulcis Thunb on alcohol degradation and liver protection in Sprague Dawley male rats. Journal of the Korean Society of Food Science and Nutrition, 2006;35:828-34.   DOI
7 You Y, Jung KY, Lee YH, Jun W, Lee BY, Hepatoprotective Effects of Hovenia dulcis Fruit on Ethanol-Induced Liver Damage in vitro and in vivo. Journal of the Korean Society of Food Science and Nutrition, 2009;38(2):154-9.   DOI
8 Xiong J, Guo Y, Li LY, Hu H, Qu XL, Sun XZ, et al., A herbal composition of semen hoveniae, radix puerariae, and fructus schisandrae shows potent protective effects on acute alcoholic intoxication in rodent models. Evidence- based Complementary and Alternative Medicine, 2012;2012:638197.   DOI
9 Cheng N, Ren N, Gao H, Lei X, Zheng J, Cao W, Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice. Food and Chemical Toxicology, 2013;55:234-40.   DOI
10 Fiore C, Eisenhut M, Krausse R, Ragazzi E, Pellati D, Armanini D, et al., Antiviral effects of Glycyrrhiza species. Phytotherapy Research, 2008;22(2):141-8.   DOI
11 Jeon JH, Park D, Shin S, Kang DH, Moon SH, Kim YB, Effect of green tea and licorice extracts on cyclophosphamide teratogenicity. Reproductive Toxicology, 2007;24(1):75.
12 Hong JY, Nam HS, Shin SR, Changes on the Antioxidant Activities of Extracts from the Ziziphus jujube Miller Fruits During Maturation. Korean Journal of Food Preservation, 2010;17(5):712-9.
13 Min SH, Park HO, Oh HS, A study on the properties of hot water extracts of Korean dried tangerine peel and development of beverage by using it. Korean Journal of Food and Cookery Science, 2002;18:51-6.
14 Kang SH, Lee YJ, Lee CH, Kim SJ, Lee DH, Lee YK, et al., Physiological Activities of Peel of Jeju-indigenous Citrus sunki Hort. Tanaka. Korean Journal of Food Science and Technology, 2005;37(6):983-8.
15 Sheo HJ, The Antibacterial Action of Garlic, Onion, Ginger and Red Pepper Juice. Journal of the Korean Society of Food Science and Nutrition, 1999;28(1):94-9.
16 Thomson M, Al-Qattan KK, Al-Sawan SM, Alnaqeeb MA, Khan I, Ali M, The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins, Leukotrienes & Essential Fatty Acids, 2002;67(6):475-8.   DOI
17 Barbalata T, Deleanu M, Carnuta MG, Niculescu LS, Raileanu M, Sima AV, et al., Hyperlipidemia Determines Dysfunctional HDL Production and Impedes Cholesterol Efflux in the Small Intestine: Alleviation by Ginger Extract. Molecular Nutrition & Food Research, 2019;63(19):e1900029.
18 Shirpoor A, Rezaei F, Fard AA, Afshari AT, Gharalari FH, Rasmi Y, Ginger extract protects rat's kidneys against oxidative damage after chronic ethanol administration. Biomedicine & Pharmacotherapy, 2016;84:698-704.   DOI
19 Bertola A, Mathews S, Ki SH, Wang H, Gao B, Mouse model of chronic and binge ethanol feeding (the NIAAA model). Nature Protocols, 2013;8(3):627-37.   DOI
20 Albano E, Free radical mechanisms in immune reactions associated with alcoholic liver disease. Free Radical Biology and Medicine, 2002;32:110-4.   DOI
21 Purohit, V, Gao B, Song BJ, Molecular mechanisms of alcoholic fatty liver. Alcoholism: Clinical and Experimental Research, 2009;33:191-205.   DOI
22 Albano E, Alcohol, oxidative stress and free radical damage. Proceedings of the Nutrition Society, 2006;65:278-90.   DOI
23 Cho HS, Lee SJ, Shin JH, Kang MJ, Cho HS, Lee HJ, et al., Antioxidative activity and nitrite scavenging effect of the composites containing medicinal plant extracts. Journal of Life Science, 2007;17: 1135-40.   DOI
24 Lee JM, Lee SH, Kim HM, Use of oriental herbs as medical food. Food Industry and Nutrition, 2000;5:50-6.
25 Lee EH, Baek SY, Kim KY, Lee SG, Kin SC, Lee HS, et al., Effect of Rheum undulatum Linne extract and Glycyrriza uralensis Fischer extract against arachidonic acid and ironinduced oxidative stress in HepG2 cell and CCl4-induced liver injury in mice. Herbal Formula Science, 2016;24(3):163-74.   DOI
26 Albano, E, Free radical mechanisms in immune reactions associated with alcoholic liver disease. Free Radical Biology and Medicine, 2002;32:110-4.   DOI
27 Lieber CS, Milestones in liver disease. Journal of Hepatology, 2004;40:198-202.   DOI
28 Lee EJ, Bae JH, Study on the Alleviation of an Alcohol Induced Hangover and the Antioxidant Activity by Mulberry Fruit. Korean Journal of Food And Nutrition, 2011;24(2):204-209.   DOI
29 Choi YJ, Jung KI, Anti-Diabetic, Alcohol-Metabolizing, and Hepatoprotective Activities of Moringa (Moringa oleifera Lam.) Leaf Extracts. Journal of the Korean Society of Food Science and Nutrition, 2016;45(6): 819-27.   DOI
30 Rasineni K, Casey CA, Molecular mechanism of alcoholic fatty liver. Indian Journal of Pharmacology, 2012;44:299-303.   DOI