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http://dx.doi.org/10.14374/HFS.2020.28.1.53

Effect of Banggibongnyeongtang on the immunohistological change in LPS-induced depression rats  

Park, Sung jun (Department of Formulae Pharmacology, College of Korean Medicine, Gachon University)
Lee, Tae Hee (Department of Formulae Pharmacology, College of Korean Medicine, Gachon University)
Publication Information
Herbal Formula Science / v.28, no.1, 2020 , pp. 53-62 More about this Journal
Abstract
Objective : This study is accomplished in order to investigate the effect of banggibongnyeongtang on the immunohistological change in LPS-induced depression rats to confirm the histological result of the previous behavioral and biochemical effect. Methods : LPS 5 ㎍ was injected to lateral ventricle and experimental groups were administered BBT intraperitoneally. The concentration of 5-HT in the Medial Prefrontal Cortex, Striatum, Hippocampus, Amygdala was measured by ELISA. IL-1β, TNF-α mRNA and BDNF mRNA expression in the hippocampus was examined by RT-PCR. Result : BBT enhanced 5-HT concentration at all part of brain but no significantly difference at medial prefrontal cortex and striatum. LPS+BBT400 group increased 5-HT concentration significantly than LPS group at hippocampus and amygdala (p<0.05). BBT decreased IL-1β mRNA expression dose dependently but only with significantly decrease in LPS+BBT400 group than LPS group's in Hippocampus (p<0.05). But BBT did not decrease TNF-α mRNA expression significantly in Hippocampus. BBT increased the expression of BDNF mRNA at hippocampus and LPS+BBT400 group significantly increased comparing with LPS group does (p<0.05). Conclusion : It is postulated that the anti-depressant effect of BBT can be validated through the anti-inflammatory effect, 5-HT concentration increase, and the neuro-protective effect mediated by BDNF by combining the results of the previous report about the behavioral and biochemical effect.
Keywords
banggibongnyeongtang; LPS; antidepression; 5-HT; IL-$1{\beta}$; TNF-${\alpha}$; BDNF;
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