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http://dx.doi.org/10.14374/HFS.2019.27.1.1

Effects of Sansachunghyul-tang (SCT) on blood cholesterol levels in Triton WR1339-induced hyperlipidemic rats  

Chang, Mun Seog (Department of Prescriptionology, College of Korean Medicine, Graduate School, Kyung Hee University)
Joo, Seung-Hun (Department of Prescriptionology, College of Korean Medicine, Graduate School, Kyung Hee University)
Kim, Eun Yi (Department of Prescriptionology, College of Korean Medicine, Graduate School, Kyung Hee University)
Park, Seong Kyu (Department of Prescriptionology, College of Korean Medicine, Graduate School, Kyung Hee University)
Publication Information
Herbal Formula Science / v.27, no.1, 2019 , pp. 1-6 More about this Journal
Abstract
Objectives : Sansachunghyul-tang (山楂淸血湯) is a new formula consist of some herbs to treatment of hyperlipidemia. The lipid-lowering effects of the water extract of Sansachunghyul-tang (SCT) were examined using Triton WR1339-induced hyperlipidemic rats. Methods : Hyperlipidemia was induced by intravenous injection of Triton WR1339 (tyloxapol) at 200 mg/kg body weight. Four groups of experimental animals were used: normal, control, and two sample groups. Sample groups were injected with SCT (100 and 1000 mg/kg) for 7 days. Results : SCT produced statistically significant lowering effects on levels of total cholesterol (81.8 and 83.1%, p < 0.01, respectively), triglyceride (88.9 and 93.4%, p < 0.01, respectively), and phospholipid (86.7 and 94.3%, p < 0.01, respectively) than the control group. Taken together, SCT improved parameters of the HDL-cholesterol and LDL-cholesterol levels. Conclusions : In conclusion, These results suggest that SCT could act as a potent antihyperlipidemic in therapeutics for hyperlipidemia.
Keywords
Hyperlipidemia; Sansachunghyul-tang (SCT); Triton WR1339;
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