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http://dx.doi.org/10.14374/HFS.2018.26.4.319

Components of Astragali Radix at Various Ages and Their Effects of Physiological Activity  

Lee, Jang-Cheon (School of Korean Medicine, Pusan National University)
Sung, Dae Dong (Department of Advanced Materials Chemistry, Sejong Campus, Korea University)
Ha, Uram (School of Korean Medicine, Pusan National University)
Lee, Boo-Kyun (School of Korean Medicine, Pusan National University)
Publication Information
Herbal Formula Science / v.26, no.4, 2018 , pp. 319-327 More about this Journal
Abstract
Objectives : Astragali Radix is known as a perennial plant, and it is estimated that there may be differences in the contents and their components depending on the ages. The components of astragali radix may activate differently. Methods : The astragali radix components cultivated in Jecheon( one year ), Korea, Shanxi province( 7 years ), China, Inner Mongolia( 5 years) and Inner Mongolia ( 8 years ) were extracted with pure ethyl alcohol and identified the component molecules. The extracted components of astragali radix were measured the activity of Telomerase for confirmation of their Telomere lengths. Results : The cell activity has been shown the greatest contribution in astragali radix of Inner Mongolia(8 years). Although there is the difference in cell activity between the two products of the 5 and 7 years, the difference between the values was small and the 7 years product was slightly higher than 5 years product. Conclusions : Total Astragaloside contents were highest in the product of Inner Mongolia(8 years), followed by the 7 year product of Shanxi province. Especially, astragaloside and cycloastragenol (TA-65) among the astragali radix components have shown to be increased Telomerase activity in the DNA metabolism of the cells, and the efficacy depends on the ages of growth.
Keywords
Astragali Radix; Telomerase; Telomere lengths;
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