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http://dx.doi.org/10.14374/HFS.2016.24.4.289

Acute toxicity, Dermal and Ocular Irritation Studies of Taglisodog-eum ointment  

Lee, Jung Bok (SONIMEDI R&D Center)
Choi, Jae Hwan (IN2BIO co. Ltd. R&D Center)
Kim, Hee Taek (College of Oriental Medicine, Semyung University)
Kim, Yun Kyung (Department of Korean Pharmacy, College of Pharmacy, Wonkwang University)
Yu, Young Beob (Department of Herbal Pharmaceutical Development, Nambu University)
Publication Information
Herbal Formula Science / v.24, no.4, 2016 , pp. 289-300 More about this Journal
Abstract
Objectives : Taglisodog-eum(TSE), a poly herbal formula, has been widely used to improve carbuncles by removing inflammation of the lymphatic channels in Traditional Korean Medicine. We previousely reported the action mechanism of TSE on experimental atopic dermatitis and the establishment of formulation for TSE ointment. In this study, we examined the toxicity test on skin and eye irritation by TSE ointment to prove the safety of Taglisodog-eum ointment in clinical use. Methods : Acute skin toxicity of the TSE ointment was evaluated in Sprague-Dawley(SD) rats. After dermal administration of TSE ointment(2,000mg/kg), body weight, mortality, and clinical signs of the rats were observed for 14days. Primary skin irritation and ocular irritation tests for TSE ointment were performed in male New Zealand White Rabbits. In dermal and ocular irritation test, body weight, mortality, clinical signs, Primary Irritation Index(P.I.I.), and The Index of Acute Ocular Irritaion(I.A.O.I.) of rabbit were observed after applying at abraded skin and eye balls with Taglisodog-eum ointment. Results : In the results of acute skin toxicity, no significant differences were found in body weight, the clinical sign and the mortality between control and TSE ointment treated group. In primary dermal irritation test, body weight, the clinical sign and the mortality were not significantly changed and Primary Irritation Index(P.I.I.) was 0.8, indicating TSE ointment as weak irritant material. In ocular irritation test, The Index of Acute Ocular Irritaion was 0.0, indicating TSE ointment as non-irritating to the eye of the rabbits. To evaluate toxicity of the TSE ointment in animal test, body weight, the clinical signs, the skin and eye irritation check were conducted; TSE ointment was considered to be weak dermal irritant in test animals. The no response of eye irritation test was observed in this experimental condition. Conclusions : According to the above toxicity test, We consider that this results is helpful for saying about the safety of TSE ointment in clinical use.
Keywords
Taglisodog-eum; ointment; Acute toxicity; Dermal and Ocular Irritation;
Citations & Related Records
Times Cited By KSCI : 7  (Citation Analysis)
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