Browse > Article
http://dx.doi.org/10.14374/HFS.2015.23.1.091

Effects of Lysimachiae Herbal extracts on Hyperlipidemic mice  

Kim, Myung Sin (College of Oriental Medicine, Dongshin University)
Kim, Kyeong Ok (College of Oriental Medicine, Dongshin University)
Kim, Kyeong Su (College of Oriental Medicine, Dongshin University)
Park, Soo Yeon (College of Oriental Medicine, Dongshin University)
Yang, Seung Joung (College of Oriental Medicine, Dongshin University)
Wei, Tung Shuen (College of Oriental Medicine, Dongshin University)
Choi, Chang Won (College of Oriental Medicine, Dongshin University)
Publication Information
Herbal Formula Science / v.23, no.1, 2015 , pp. 91-99 More about this Journal
Abstract
Objectives : Herba on lipid levels in serum and lipid accumulation in liver tissue in high fat diet-induced hyperlipidemic mice. Methods : Experimental groups were subdivided into four; Normal diet group (Nor), Hyperlipidemic mice (Con), Lysimachiae Herba water extract administered mice (LWE), Lysimachiae Herba methanol extract administered mice (LME). Thereafter the changes in body weight, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, AST, ALT, fasting blood glucose in serum were measured. In addition histopathological changes in liver tissue was also observed. Results : Body weight, AST and ALT were not affected by the administration of water or methanol extracts of Lysimachiae Herba. However, methanol extracts of Lysimachiae Herba down regulated the total cholesterol and triglyceride in high fat diet - induced hyperlipidemic mice. Conclusions : In this study, results of total cholesterol and triglyceride showed significant effect in LME compared with LWE, but other results didn’t. Therefore, it is necessary to have more study of Lysimachiae Herba to apply hyperlipidemia.
Keywords
Lysimachiae Herba; High fat diet; Hyperlipidemia;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
연도 인용수 순위
1 Shin HS, Kim GY, Kim HH, Seo IB. Curative Effects of Typhae Pollen on the Diet-Induced Hyperlipidemia in Rats. Korean J. Oriental Physiology & Pathology. 2003;17(1):225-9.
2 Lee YH, Lee WC, HWANG JW. Effects of Polygoni Multiflori Radix on Cerebral Ischemia of Hyperlipidemic Rats. Journal of Korean Medicine. 2005;26(3):146-61.
3 Kim TH, Soh KS, Jeong CG. Experimental Study on the Effects of Carthami Flos on the Hyperlipidemic Rats Induced by Triton WR-1339. Korean J. Oriental Preventive Medical Society. 2003;7(2):75-83.
4 Kim HJ, Kim JB. Effects of Astragali Radix on the Diet-induced Hyperlipidemia in Rats. Korean J. Oriental Physiology & Pathology. 2008;22(3):575-9.
5 Kim MS, Seo IB, Kim JB. Effects of Salviae Miltiorrhizae Radix on the Diet-induced Hyperlipidemia in Rats. Korean J. Oriental Physiology & Pathology. 2004;18(2):431-5.
6 Lee SK, Lee SS, Baek JW, Lee SJ, Kim KH. Effect of CRATAEGII FRUCTUS on Sarum Lipid in High Cholesterol Diet Induced Hyperlipide Rats. Korean J. Oriental Preventive Medical Society. 2003;7(2):13-22.
7 Rosenfeld L. Lipoprotein analysis. Arch pathol Lab. 1989;113:1101-10.
8 Kim JJ. Characteristics and treatment of hyperlipidemia. Seoul:Yakupsinmusa. 1994(12):50-3.
9 Choi JW, Park JC, Lee CH. Biological Activities of Lysimachiae Herba II-Analgesic and antiinflammatory effects of ethylacetate fraction and a phenyl propanoid component. Nature Product Science. 1997,3(2):135-140.
10 Choi JW, Kim HY, Kim SS, Lee CK. Biological Activities of Lysimachiae Herba . I - Effcets of the Pretreatment of Lysimachiae Herba on the Enzyme Activities in Galactosamine- intoxicated Rats. Korean J. Pharmacogn. 1996; 27(1):58-64.
11 Kang BS, Kim YP. Imsangbaehapbonchohak. Seoul:Younglimsa. 1994:530-1.
12 Wang J, Zhang Y, Zhang Y, Cui Y, Liu J, Zhang B. Protective effect of Lysimachia christinae against acute alcohol-induced liver injury in mice. Biosci Trends. 2012 Apr;6(2): 89-97.
13 Yang X, Wang BC, Zhang X, Liu WQ, Qian JZ, Li W, Deng J, Singh GK, Su H. Evaluation of Lysimachia christinae Hance extracts as anticholecystitis and cholagogic agents in animals. J Ethnopharmacol. 2011 Sep 1;137(1):57-63.   DOI
14 Kim JK. Clinical Lipid Science. Seoul:Uihak Publisher. 1995:241-70.
15 Kim YC, Kim IY, Choi YS, Shin HC, Park ES. A study of relationship between hypertension and hyperlipidemia in the health screening center. J Korean Acad Fam Med.1992;13(5):410-1.
16 Korea Centers for Disease Control and Prevention. Korea National Health & Nutrition Examinations Survey in 2011 (https://knhanes.cdc.go.kr/knhanes/index.do). 2012.
17 Hyperlipidemia treatment guideline committee established. Diagnosis and Treatment of Hyperlipidemia. Seoul:Hanuihak Publisher. 2000.
18 Park DB, Sung HJ, Kim EH. Effects of Cervi Pantorichum on Hyperlipidemia in Rats. Korean J. Oriental Physiology & Pathology. 2006;20(2):372-6.
19 Kasper, Braunwald, Fauci, Hauser, Longo, Jamesom. Harrison’s Principle of Internal Medicine 16th. Seoul:MIP. 2006:2500-1.
20 Kim JJ. Property and Managment of hyperlipidemia. Seoul:Yakupsinmunsa. 1994:50-3.
21 Lee KI, Sohn ES. Development Trend of Hyperlipidemia Treatment Medicine. Seoul:Korea Institute of Science and Technology Infomation. 2005:7.
22 Cater NB. Plant stanol ester: review of cholesterol-lowering efficacy and implications ofr coronary heart disease risk reduction. Prev Cardiol. 2000, Summer; 3(3):121-30.   DOI
23 Jones PJ. Cholesterol-lowering action of plant sterols. Curr Atheroscler Rep. 1999, Nov;1(3): 230-5.   DOI
24 Park Js, Park HD, Yun JW, Jung CH, Lee MY, Kim SW. Prevalence of the metabolic syndrome as defined by NCEP-ATPIII among the urban Korean population. Korean Journal of Med. 2002;63(3):290-8.
25 Hwang MD. Practical Internal Medicine. Shanghai: Inminwisaeng Publisher. 1986:414-22.
26 Cho YK. Analysis of hyperlipidemia therapies trial. Jounal of Traditional Chinese medicine. 1988;29(7):66.
27 The co-textbook publishing committee of Korean oriental medicine school. The herbalmedicine. Seoul:Younglimsa. 2004:451-2.
28 Lee YJ, Sohn YJ, Lee ES, Park JS, Kim SK. Effects of Coicis Semen on the Hyperlipidemia in Rat. Korean J of herbology. 2004;19(3):129-36.
29 Roh SW, Kim JB. Effects of Polygonati Rhizoma on the Diet-induced Hyperlipidemia in Rats. Korean J. Oriental Physiology & Pathology. 2008;22(5):1147-51.
30 Woo WS. Natural Products Chemistry Studies. Seoul:Seoul University Press. 2008:12.
31 Ham IH, Jung SW, Lee KJ, Park KH, Choi HY. Effect of the aerial part of Artemisia capillaris, and A. iwayomogi on the Hyperlipidemia of Rats induced by Triton WR-1339. Korean J of herbology. 2005;20(1):9-17.