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http://dx.doi.org/10.14374/HFS.2015.23.1.121

Study of Membrane Potential Analysis According to Applying Doksam-tang to a Human Heart Failure Model  

Jeong, Dae-Yeong (school of Korean Medicine, Pusan National University)
Lee, Boo-Kyun (School of Korean Medicine, Pusan National University)
Hong, Jin-Woo (School of Korean Medicine, Pusan National University)
An, Won-Gun (School of Korean Medicine, Pusan National University)
Publication Information
Herbal Formula Science / v.23, no.1, 2015 , pp. 121-131 More about this Journal
Abstract
Objectives : This study was conducted to investigate the membrane potential to apply Doksam-tang to a human heart failure model. Methods : The human heart model was built by Luo et al. CellML model, Priebe et al. CellML model, and a human heart mesh file. Doksam-tang gives channel the half maximal inhibitory concentration(IC 50 ), half maximal effective concentration(EC 50 ) values and compounds concentrations. These data load into the laptop with Ubuntu OS, and build the library with the data. Results : While results of the study with the heart failure model shows abnormal membrane potential from the normal heart model, the study with applying Doksam-tang to heart failure model shows restoring membrane potential that is similar to normal heart model. Conclusions : These results of the testings suggest that a conception of novel technique to investigate the effects of Korean herbal medicine.
Keywords
heart failure; computer modelling; Doksam-tang; physiome; korean medicine; systems biology.;
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