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http://dx.doi.org/10.14374/HFS.2014.22.2.035

Antiproliferative Effect of the Salviae miltiorrhizae Radix Extracts on the Cancer Cell Lines  

Yang, Weo-Ho (Department of Internal Medicine, College of Korean Medicine, Dong-shin University)
Jung, Tae-San (Department of Internal Medicine, College of Korean Medicine, Dong-shin University)
Choi, Chang-Won (Department of Internal Medicine, College of Korean Medicine, Dong-shin University)
Publication Information
Herbal Formula Science / v.22, no.2, 2014 , pp. 35-43 More about this Journal
Abstract
Objectives : The purpose of this study was to identify antiproliferative effects of Salviae miltiorrhizae Radix(SM) extracts against cancer cell lines. Methods : We used 2 kinds of cancer cell lines such as colon cancer cells(HT-29), human oral epitheloid carcinoma cells(KB). MTT assay was performed to examine the efficacy of SM extracts on the cytostaticity of cancer cells in proportion to time and doses. Apoptosis was evaluated by DNA laddering and DAPI nuclei staining. Results : The MTT absorbances against HT-29 and KB of SM extracts were significantly decresed. DNA ladders could be identified in KB of SM extracts. The morphological change were observed and number of cells were decreased by SM extracts. Conclusions : SM extracts is considered to be effective to induce apoptosis and inhibit cancer cell proliferation.
Keywords
Salviae miltiorrhizae Radix; Antiproliferative effect; Cancer cell lines;
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Times Cited By KSCI : 4  (Citation Analysis)
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