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http://dx.doi.org/10.14374/HFS.2014.22.2.105

Comparison of Gangjihwan and Combination of Gangjihwan and Gamisochehwan in the Improvement Effects of Weight Loss in a High Fat Diet-Fed Obese Mice  

Seok, Hoa Jun (Soojung Korean Medicine Clinic)
Yoo, Jae Sang (Bonghwang Korean Medicine Clinic)
Ku, Ja Ryong (Soricheong Luck Korean Medicine Clinic)
Yoon, Ki Hyeon (Dept. of Formula Sciences and Research Center of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University)
Jo, Ju Heum (Woosim Korean Medicine Clinic)
Jang, Du Hyon (Chungnam Korean Medicine Clinic)
Jung, Yang Sam (Jungyangsam Korean Medicine Clinic)
Kim, Jong Hoon (Neungin Korean Medicine Clinic)
Kim, Byeong Chul (Goryo Korean Medicine Clinic)
Roh, Jong Seong (Dept. of Formula Sciences and Research Center of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University)
Lee, Hye Rim (Dept. of Formula Sciences and Research Center of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University)
Lee, Hyunghee (Division of Medical Engineering and Health Management, Mok-Won University)
Yoon, Michung (Division of Medical Engineering and Health Management, Mok-Won University)
Shin, Soon Shik (Dept. of Formula Sciences and Research Center of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University)
Publication Information
Herbal Formula Science / v.22, no.2, 2014 , pp. 105-120 More about this Journal
Abstract
Objectives : This study was investigated the improvement effects of Gangjihwan (DF) and combination of Gangjihwan and Gamisochehwan (GSH) on obesity in a high fat diet-fed obese mouse model. Methods : Eight-week-old C57BL/6N mice were divided into four groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and DF and DF+GSH groups given a high fat diet with DF (40 mg/kg), and DF+GSH (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, feeding efficiency ratio, blood lipid markers, fat weight and histology were examined. Results : 1. Body weight gain and fat mass were significantly decreased in DF and DF+GSH groups compared with control. The extent of decreases was eminent in DF+GSH group. 2. Feeding efficiency ratio and circulating concentration of leptin were decreased in DF and DF+GSH groups compared with control. These decreases were significant in DF+GSH group. 3. Consistent with their effects on body weight gain and fat mass, circulating concentrations of triglyceride, glucose and insulin were decreased in DF and DF+GSH groups compared with control. 4. The size of adipocytes was decreased by DF and DF+GSH compared with control, whereas the adipocyte number per unit area was increased by them, suggesting that DF and DF+GSH decreased the number of large adipocytes. 5. Consistent with their effects on body weight gain, liver fibrosis was also improved in DF and DF+GSH groups compared with control. Conclusions : In conclusion, these results suggest that DF and DF+GSH groups decrease feeding efficiency ratio, plasma leptin concentration, blood anti-obesity biomarkers and fat mass, improves body weight gain contributing to the inhibition of liver fibrosis. In addition, these effects were more effective in DF+GSH combination group than in DF-only group.
Keywords
Gangjihwan; obesity; Gamisochehwan; liver fibrosis; leptin;
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Times Cited By KSCI : 2  (Citation Analysis)
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