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http://dx.doi.org/10.14374/HFS.2013.21.2.044

The Anti-obesity Effect of 5 Herbal Formulas in High Fat Diet Induced Obese Mice  

Chun, Jin Mi (Herbal Medicine Resource Group, Korea Institute of Oriental Medicine)
Choi, Goya (Herbal Medicine Resource Group, Korea Institute of Oriental Medicine)
Kim, Dong-Seon (Herbal Medicine Resource Group, Korea Institute of Oriental Medicine)
Sung, Yoon-Young (Herbal Medicine Resource Group, Korea Institute of Oriental Medicine)
Nho, Kyoung Jin (Herbal Medicine Resource Group, Korea Institute of Oriental Medicine)
Kim, Seung-Hyung (Institute of Traditional Medicine and Bioscience in Daejeon University)
Kim, Ho Kyoung (Herbal Medicine Resource Group, Korea Institute of Oriental Medicine)
Publication Information
Herbal Formula Science / v.21, no.2, 2013 , pp. 44-52 More about this Journal
Abstract
Objectives : Samhwangsasim-tang (SST), Hwangryeonhaedok-tang (HHT), Ukgan-san (UGS), Onjunghwadam-hwan (OHH) and Samul-tang (SMT) have been used for the treatment of various diseases. This study was performed to compare the anti-obesity effects of 5 herbal formulas in high fat diet-(HFD) induced obese mice. Methods : The mice were randomly divided into seven groups that were fed a normal diet (ND), a HFD, a HFD plus SST (HFD + SST), a HFD plus HHT (HFD + HHT), a HFD plus UGS (HFD + UGS), a HFD plus OHH (HFD + OHH), or HFD plus SMT (HFD + SMT) at 300 mg/kg/day for 7 weeks. All groups were assayed for body weights, food efficiency ratio (FER), final liver and fat weight and blood biochemical parameters. Results : The increased body weights, food efficiency ratio (FER), and serum total triglyceride were decreased in HFD + OHH group relative to the same measurements in HFD group. Furthermore, the HFD + SST group significantly reduced FER, liver and abdominal subcutaneous fat weight gains, and serum total triglyceride, whereas HDL-cholesterol level was increased compared to HFD group. Conclusions : These results suggested that HFD + OHH and HFD + SST exert anti-obesity effects in HFD-induced obese mice.
Keywords
5 herbal formulas; Anti-obesity effects; High-fat diet-induced obese mice; Onjunghwadam-hwan; Samhwangsasim-tang;
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Times Cited By KSCI : 13  (Citation Analysis)
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1 Park MJ. Recent advances in regulating energy homeostasis and obesity. Korean J. Pediatr. 2005; 48(2):126-37.   과학기술학회마을
2 Ministry of Health and Welfare Korea Centers for Disease Control and Prevention. Korea Health Statistics 2011: Korea National Health and Nutrition Examination Survey (KNHANES V-2). 2011;52-3.
3 Despres JP, Lemieux I. Abdominal obesity and metabolic syndrom. Nature. 2006;444(7121):881-7.   DOI   ScienceOn
4 Jornayvaz FR, Samuel VT, Shulman GI. The role of muscle insulin resistance in the pathogenesis of atherogenetic dyslipidemia and nonalcoholic fatty liver disease associated with metabolic syndrom. Annu Rev Nutr. 2010;30:273-90.   DOI   ScienceOn
5 Song MY, Kim EK, Kong JC, Lee JH, Shin BC, Ryu DG, Kwon KB. Inhibitory Effect of Daesiho-tang (Dachaihu-tang) Extracts on High-fat Dietinduced Obesity. J Oriental Rehab Med. 2008;18(3):41-9.
6 Park SW, Cho CS, Kim CJ. Effect of Yagwan-cheunghyeoltang on Obesity in Rats Induced by High Fat Diet. Korean J. Orient. Int. Med. 2011;32(2):170-87.   과학기술학회마을
7 Song HN, Lee HH, Kim JB. Effects of Water Extract of Yukeuigambi-tang on Obesity and Hyperlipidemia in Mice Induced by High Fat Diet. Korean J. Oriental Physiology & Pathology. 2011;25(6):1026-31.   과학기술학회마을
8 Wang S, Song HN, Choi WI, Park JH Jeong YJ, Kang SC, Ko SK, Bhang DH. Identification of Anti-obesity Constituents from Yukeuigambitang. Korean J. Plant Res. 2012;25(2):271-6.   과학기술학회마을   DOI   ScienceOn
9 Seo CS, Jeong SJ, Kim JH, Yoo SR, Shin HK. Simultaneous Analysis and Anti-obesity Effect of Taeeumin Cheongsimyeonja-tang. J Sasang Constitut Med. 2013;25(1):51-61   과학기술학회마을   DOI   ScienceOn
10 Jeong HS. Efficacy of Alismatis Orientale Rhizoma on Obesity induced by High Fat Diet. Kor J Herbology. 2013;28(3):95-106.   과학기술학회마을   DOI   ScienceOn
11 Sung YY, Yoon T, Yang WK, Kim SJ, Kim DS, Kim HK. The Antiobesity Effect of Polygonum aviculare L. Ethanol Extract in High-Fat Diet-Induced Obese Mice. Evid Based Complement Alternat Med. 2013; 2013:626397.
12 Lee HY. Yoon KH, Seo BI, Park GR, Yoon MC. Shen ZB, Cui HH, Shin SS. Molecular biologic mechanism of obesity by GGEx18. Kor J Herbology. 2011;26(1) :65-74.   과학기술학회마을
13 Lee HC, Choi YM, Shim WJ, Kim KS, Choi SM, Kang BK, Shin SU. The Study of the Relationship with Abdominal Visceral Fat in Obese Patients Identified as Phlegm Type. Journal of society of Korean medicine for obesity research. 2006;6(1): 51-9.   과학기술학회마을
14 Chung MH, Han SJ. Effect of Composite Preparation of Crude Drugs on Experimentally Induced Hyperlipemia in Rats Sam Whang Sasim Tang and Whang Ryun Haedok Tang. Kor J Pharmacogn. 1996;27(4): 397-407.   과학기술학회마을
15 Lee JM, Lee E. Antihyperlipidemic and antioxidant effects of Samhwangsasimtang aqua-acupuncture. J Kor pharmacopuncture. 2005;8(1):51-7.   과학기술학회마을   DOI   ScienceOn
16 Kim YS, Jung EA, Chang JC, Yang HK, Kim NJ, Cho GH, Hae HS, Lee KS, Kim DH. Effect of Daewhangwhangryunhaedok- Tang on Hyper-lipidemia. Kor J Pharmacogn. 2001;32(2):145-52.
17 Kwak DH, Lee JH, Kim DG, Kim T, Lee KJ, Ma JY. Inhibitory Effects of Hwangryunhaedok-Tang in 3T3-L1 Adipogenesis by Regulation of Raf/MEK1/ ERK1/2 Pathway and PDK1/Akt Phosphorylation. Evid Based Complement Alternat Med. 2013;2013: 413906.
18 Hwang S, Song T, Oh M. The Inhibitory Effects of Bangpungtongseoung-san on the Obese gene and Obese Inhibitory about Obese-mouse induced by High Fat Diet. J Korean Oriental Med. 2006;27(1) :11-22.   과학기술학회마을
19 Schnell MA, Hardy C, Hawley M, Propert KJ, Wilson JM. Effect of blood collection technique in mice on clinical pathology parameters. Hum Gene Ther. 2002;13(1):155-61.   DOI   ScienceOn
20 Cha MK, Lee JY, Kim DG, Lee KT. Effects of Bangpoongtongsungsan on Adipose Tissue and Hyperlipidemia of 3T3-L1 Induced Rats. J Korean Oriental Pediatrics. 2006;20(2):177-96.   과학기술학회마을
21 DiGirolamo M, Fine JB, Tagra K, Rossmanith R. Qualitative regional differences in adipose tissue growth and cellularity in male Wistar rats fed and libitum. Am J Physiol. 1998;274(5 Pt2 ):1460-7.
22 Kim AR, Hwang YG, Lee JJ, Jung HO, Lee MY. Effects of Eriobotrya japonica Lindl. (Loquat) Leaf Ethanol Extract on Cholesterol and Antioxidative Activity in Rats Fed a High-Fat/High-Cholesterol Diet. J Korean Soc Food Sci Nutr. 2011;40(5):673-81.   과학기술학회마을   DOI   ScienceOn
23 Goldberg IJ. Lipoprotein lipase and lipolysis:central roles in lipoprotein metabolism and atherogenesis. J Lipid Res. 1996;37(4):693-707.
24 Assmann G, Schulte H. The Prospective Cardiovascular Mü nster (PROCAM) study: prevalence of hyperlipidemia in persons with hypertension and/or diabetes mellitus and the relationship to coronary heart disease. Am Heart J. 1988;116(6 Pt 2):1713-24.   DOI   ScienceOn
25 "NIH stops clinical trial on combination cholesterol treatment". National Institute of Health. National Heart, Lung, and Blood Institute (NHLBI). Retrieved 2 June 2011. http://www.nih.gov/news/health/may2011/nhlbi -26.htm
26 Chang Ho Park, Hee Kyoung Jung, Yoo Seok Jeong, Joo Heon Hong, Gee Dong Lee, Chi Deok Park. Effects of Citrus Peel Ethanol Extract on the Serum Lipid and Body Fat of High-fat-diet-fed Rats. Korean J Food Preserv. 2011;18(4):567-74.   과학기술학회마을   DOI   ScienceOn
27 Hwan Seong Ro, Woo Kyoung Ko, Oon Ja Kim, Kun Koo Park, Young Whan Cho, Hyoungsup Park. Antihyperlipidemic Activity of Scutellaris baicalensis Georg., Coptidis japonica Makino and Rhei koreanum Nakai on Experimental Hyperlipidemia in Rats. J Kor Pharm Sci. 1996;26(3):215-9.   과학기술학회마을
28 Youngjong Son,Yunsang Kim,Youngjong Lee. The Effects of Rhei palmati Radix and Rhei undulati Radix on the Blood Lipids and Enzymes of Hypercholesterolic Rats. Kor J Herbology. 1999;14(1):61-8.   과학기술학회마을
29 Youngjong Lee. The Effects of Fraction Obtained from Rhei Rhizoma on the Blood Lipids in Hypercholesterol Rats. Kor J Herbology. 2000;15(2):87-93.   과학기술학회마을
30 Beattie JH, Nicol F, Gordon MJ, Reid MD, Cantlay L, Horgan GW, Kwun IS, Ahn JY, Ha TY. Ginger phytochemicals mitigate the obesogenic effects of a high-fat diet in mice: a proteomic and biomarker network analysis. Mol Nutr Food Res. 2011;55(2): S203-13.   DOI   ScienceOn