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http://dx.doi.org/10.14374/HFS.2013.21.1.119

Therapeutic Effect of Doinseunggi-tang on Diabetic Vascular Dysfunction  

Lee, Yun Jung (College of Oriental Medicine, Professional Graduate School of Oriental Medicine, Hanbang Body-fluid research center, Wonkwang University)
Kim, Eon Kuk (Professional Graduate School of Oriental Medicine, Wonkwang University)
Kim, Hye Yoom (College of Oriental Medicine, Professional Graduate School of Oriental Medicine, Hanbang Body-fluid research center, Wonkwang University)
Yoon, Jung Joo (College of Oriental Medicine, Professional Graduate School of Oriental Medicine, Hanbang Body-fluid research center, Wonkwang University)
Lee, So Min (College of Oriental Medicine, Professional Graduate School of Oriental Medicine, Hanbang Body-fluid research center, Wonkwang University)
Lee, Yong-Pyo (College of Oriental Medicine, Professional Graduate School of Oriental Medicine, Hanbang Body-fluid research center, Wonkwang University)
Lee, Geon Mok (Professional Graduate School of Oriental Medicine, Wonkwang University)
Kang, Dae Gill (College of Oriental Medicine, Professional Graduate School of Oriental Medicine, Hanbang Body-fluid research center, Wonkwang University)
Lee, Ho Sub (College of Oriental Medicine, Professional Graduate School of Oriental Medicine, Hanbang Body-fluid research center, Wonkwang University)
Publication Information
Herbal Formula Science / v.21, no.1, 2013 , pp. 119-130 More about this Journal
Abstract
Objectives : Diabetes mellitus is the leading cause for vascular complications such as atherosclerosis. The present study is to investigate whether Doinseunggi-tang (DST) improves diabetic vascular dysfunction in type II diabetes. Methods : The db/db mice were treated with high fat/high cholesterol diet and DST (200 mg/kg/day) for 8 weeks. Results : DST significantly lowered blood glucose and systolic blood pressure. In addition, DST also markedly decreased total plasma cholesterol, triglyceride, and LDL-cholesterol, whereas increased the HDL-cholesterol. Vascular relaxation of aortic rings by acetylcholine or SNP was ameliorated by DST in a dose-dependent manner. Damage of vascular intima and hypertrophic of media was improved by DST. Immunohistological study revealed that DST attenuated the increase of ICAM-1, VCAM-1, and ET-1 expression in thoracic aorta. Conclusions : Taken together, DST suppressed hyperglycemia and diabetic vascular dysfunction in type II db/db mice. The present data suggests that Doinseunggi-tang may be prevent a development of diabetic atherosclerosis.
Keywords
Doinseunggi-tang; Hypertension; Diabetes; Vasorelaxation; Cholesterol;
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