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http://dx.doi.org/10.14374/HFS.2011.19.2.011

Effect of Hwangyeonhaedok-tang on Experimental Mouse Colitis Induced by Dextran Sulfate Sodium  

Lim, Dae-Hwan (Gam-Cho Oriental Medicine)
Yun, Ji-Yeon (Dept. of Oriental Medical Prescription, Won-Kwang University)
Jang, Seon-Il (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeon-Ju University)
Yun, Young-Gab (Dept. of Oriental Medical Prescription, Won-Kwang University)
Publication Information
Herbal Formula Science / v.19, no.2, 2011 , pp. 11-22 More about this Journal
Abstract
Objectives : Hwangyeonhaedok-tang(HHDT) has been traditionally used for various clinical symptoms associated with gastrointestinal disorder, cardiovascular diseases, and inflammation in the Oriental medicine. However, little is known for antioxidant and anti-inflammatory effects of HHDT on dextran-sulfate sodium(DSS)-induced colitis in mice. Methods : In this study, we investigated an antioxidant and anti-inflammatory effects of HHDT on DSS-induced colitis in mice. An experimental colitis was induced by daily treatment with 5% DSS. HHDT was orally administrated the various concentrations(25-100 mg/kg, body weight/day) for 7 days with one time per day. Results : HHDT reduced significantly clinical sign of DSS-induced colitis, including body weight loss, shorten colon length, disease activity index(DAI), and histological colon injury. HHDT also inhibited significantly serum NO and prostaglandine $E_2(PGE_2)$ productions in DSS-induced colitis mice. Furthermore, HDDT increased significantly an superoxide anion(SOD), catalase, and glutathione peroxidase(GPx) activity of the colon tissue in DSS-induced colitis mice. Conclusions : These results suggest that HHDT administration could reduce significantly the clinical signs and inflammatory mediators, and increase antioxidant activity in DSS-induced colitis model mice and is a good candidate for further evaluation as an effective anti-ulcerative agent.
Keywords
Hwangyeonhaedok-tang(HHDT); Dextran-sulfate sodium(DSS) disease activity index (DAI); Anti-inflammation; Antioxidant;
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