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Effects of Rehmanniae Radix on HPA Axis System and Catecholamienrgic System in FST  

Park, Jae-Beom (Dept. of Formulae Pharmacology, College of Oriental Medicine, Kyungwon University)
Lee, Tae-Hee (Dept. of Formulae Pharmacology, College of Oriental Medicine, Kyungwon University)
Publication Information
Herbal Formula Science / v.18, no.1, 2010 , pp. 133-144 More about this Journal
Abstract
Object : The effects of Rehmanniae Radix(RR) on HPA Axis system and Catecholaminergic system was investigated. Methods : we performed the Forced Swimming Test(FST). Also the expression of Corticotropin -Releasing Factor(CRF), c-Fos and Tyrosine Hydorxylase(TH) was measured by immunohistochemical method at Paraventricular Nucleus(PVN), Locus Coeruleus(LC) and Ventral Tegmental Area(VTA). Results : 1. The duration of immobility in the Forced Swimming Test was significantly decreased in the Rehmanniae Radix 400 mg/kg groups in comparison with the control group(p<0.05). 2. Comparing to the control group, CRF expression was significantly decreased in the Rehmanniae Radix 400 mg/kg treated group in comparison with the control group(p<0.01). 3. c-Fos expression was significantly decreased at PVN in the Rehmanniae Radix 100 mg/kg treated group in comparison with the control group(p<0.01). 4. TH expression was significantly increased at LC in the Rehmanniae Radix 100 mg/kg and 400 mg/kg treated group in comparison with the control group(p<0.001). 5. TH expression was significantly decreased at VTA in the Rehmanniae Radix 100 mg/kg and 400 mg/kg treated group in comparison with the control group(p<0.001). Conclusion : According to the results, it can be considered that Rehmanniae Radix has antidepressant effect by showing the reduction of immobility in FST through the decreased expression of CRF, c-Fos in PVN and TH in VTA.
Keywords
Rehmanniae Radix; FST; CRF; c-Fos; TH; Anti-depression;
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Times Cited By KSCI : 9  (Citation Analysis)
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