Browse > Article
http://dx.doi.org/10.5407/jksv.2021.19.1.012

3D-inertia Valve Component for Centrifugal Force-based Micro Fluid Control  

Kang, Dong Hee (Department of Mechanical Engineering, Chonnam National University)
Kim, Na Kyong (Department of Mechanical Engineering, Chonnam National University)
Kang, Hyun Wook (Department of Mechanical Engineering, Chonnam National University)
Publication Information
Journal of the Korean Society of Visualization / v.19, no.1, 2021 , pp. 12-17 More about this Journal
Abstract
A three-dimensional slope valve component is used for controlling micro volume of liquid on a centrifugal force-based microfluidic disk platform, also called a lab-on-a-disk. The modeling factor of the slope valve component is determined to centrifugal force for liquid passing the crest of a slope valve via variation of slope length and angle as well as the radius to start point of slope valve. The centrifugal force is calculated by the equilibrium equation of the capillary and gravitational forces according to the microchannel surface roughness and the liquid volume, respectively. As a result, the slope valve is analyzed by the minimum angular velocity for liquid passing at crest point and the ratio between the length of micro liquid and slope length to obtain the factors for optimal slope angle modeling.
Keywords
Microfluidics; Lab-on-a-disk; Centrifugal force; slope valve;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Steigert, J., Brenner, T., Grumann, M., Riegger, L., Lutz, S., Zengerle, R., and Ducree, J., 2007, "Integrated siphon-based metering and sedimentation of whole blood on a hydrophilic lab-on-a-disk," Biomedical microdevices, Vol. 9(5), pp. 675-679.   DOI
2 Riegger, L., Grumann, M., Nann, T., Riegler, J., Ehlert, O., Bessler, W., Mittenbuehler, K., Urban, G., Pastewka, L., Brenner. T., and Zengerle, R., 2006, "Read-out concepts for multiplexed bead-based luorescence immunoassays on centrifugal microfluidic platforms," Sensors and Actuators A: Physical, Vol. 126(2), pp. 455-462.   DOI
3 Miyazaki, C. M., Kinahan, D. J., Mishra, R., Mangwanya, F., Kilcawley, N., Ferreira, M., and Ducree, J., 2018, "Label-free, spatially multiplexed SPR detection of immunoassays on a highly integrated centrifugal Lab-on-a-Disc platform," Biosensors and Bioelectronics, Vol. 119, pp. 86-93.   DOI
4 La, M., Park, S. J., Kim, H. W., Park, J. J., Ahn, K. T., Ryew, S. M., and Kim, D. S., 2013, "A centrifugal force-based serpentine micromixer (CSM) on a plastic lab-on-a-disk for biochemical assays," Microfluidics and nanofluidics, Vol. 15(1), pp. 87-98.   DOI
5 Gorkin III, R., Nwankire, C. E., Gaughran, J., Zhang, X., Donohoe, G. G., Rook, M., O'Kennedy, R., and Ducree, J., 2012, "Centrifugo-pneumatic valving utilizing dissolvable films," Lab on a Chip, Vol. 12(16), pp. 2894-2902.   DOI
6 Mark, D., Metz, T., Haeberle, S., Lutz, S., Ducree, J., Zengerle, R., and von Stetten, F., 2009, "Centrifugo-pneumatic valve for metering of highly wetting liquids on centrifugal microfluidic platforms," Lab on a Chip, Vol. 9(24), pp. 3599-3603.   DOI
7 Park, J. M., Cho, Y. K., Lee, B. S., Lee, J. G., and Ko, C., 2007, "Multifunctional microvalves control by optical illumination on nanoheaters and its application in centrifugal microfluidic devices," Lab on a Chip, Vol. 7(5), pp. 557-564.   DOI
8 Kang, D. H., Kim, N. K., Park, S. W., Lee, W., and Kang, H. W., 2020, "A microfluidic circuit consisting of individualized components with a 3D slope valve for automation of sequential liquid control," Lab on a Chip, Advanced article.
9 Lee, B. S., Lee, J. N., Park, J. M., Lee, J. G., Kim, S., Cho, Y. K., and Ko, C., 2009, "A fully automated immunoassay from whole blood on a disc," Lab on a Chip, Vol. 9(11), pp. 1548-1555.   DOI
10 Clime, L., Brassard, D., Geissler, M., and Veres, T., 2015, "Active pneumatic control of centrifugal microfluidic flows for lab-on-a-chip applications," Lab on a Chip, Vol. 15(11), pp. 2400-2411.   DOI