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http://dx.doi.org/10.5407/JKSV.2018.16.2.031

Evaluation of the Biomechanical Characteristics of Ischemic Mitral Regurgitation: Effects of Asymmetric Papillary Muscle Displacement and Annular Dilation  

Hong, Woojae (Department of Biomechatronic Engineering, Sungkyunkwan University)
Kim, Hyunggun (Department of Biomechatronic Engineering, Sungkyunkwan University)
Publication Information
Journal of the Korean Society of Visualization / v.16, no.2, 2018 , pp. 31-37 More about this Journal
Abstract
Ischemic mitral regurgitation (IMR) is the primary mitral valve (MV) pathology in the aftermath of myocardial infarction as a consequence of regional left ventricular (LV) remodeling. We investigated the effect of asymmetric papillary muscle (PM) displacement and annular dilation on IMR development. Virtual MV modeling was performed to create a normal human MV. Asymmetric PM displacement, asymmetric annular dilation, and the combination of these two pathologic characteristics were modeled. Dynamic finite element evaluation of MV function was performed across the complete cardiac cycle for the normal and three different IMR MV models. While the normal MV demonstrated complete leaflet coaptation, each pathologic MV model clearly revealed deteriorated leaflet coaptation and abnormal stress distributions. The pathologic MV model having both asymmetric PM displacement and annular dilation showed the worst leaflet malcoaptation. Simulation-based biomechanical evaluation of post-ischemic LV remodeling provides an excellent tool to better understand the pathophysiologic mechanism of IMR development.
Keywords
Mitral valve; Ischemic mitral regurgitation; Papillary muscle; Annular dilation; Simulation;
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