Browse > Article
http://dx.doi.org/10.5407/JKSV.2018.16.1.042

Experimental Investigation on Key Parameters in Air-powered Needle-free Injection System for Skin Treatment  

Kim, Jung Kyung (School of Mechanical Engineering, Kookmin University)
Mohizin, Abdul (Department of Mechanical Engineering, Graduate School, Kookmin University)
Lee, Seung Ku (Union Medical Co.)
Publication Information
Journal of the Korean Society of Visualization / v.16, no.1, 2018 , pp. 42-47 More about this Journal
Abstract
A needle-free injector is one of the new non-invasive players in impregnating the biological barriers. It is considered as the next phase in drug delivery and therapeutic applications. One of the major fields of application is in skin remodeling procedures. Although many studies were carried out in understanding the principle in the needle-free injection procedure, fewer studies were done with the aim of therapeutic applications. In the present study, we tried to identify key parameters that affect the jet divergence and peak stagnation pressure on the skin surface in a conventional needle-free injector for skin treatment. A summary of the working principle and effect of the key parameters are presented.
Keywords
Skin Treatment; Needle-free Injection; Fluid Microjet; Skin Penetration; Stagnation Pressure;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Chen, K., Zhou, H., Li, J., and Chen, G. J., 2010, "A Model on Liquid Penetration Into Soft Material With Application to Needle-Free Jet Injection," J. Biomech. Eng., Vol. 132(10), p. 101005.   DOI
2 Kato, T., Arafune, T., Washio, T., Nakagawa, A., Ogawa, Y., Tominaga, T., Sakuma, I., and Kobayashi, E., 2014, "Mechanics of the Injected Pulsejet into Gelatin Gel and Evaluation of the Effect by Puncture and Crack Generation and Growth," J. Appl. Phys., Vol. 116(7), p. 074901.   DOI
3 Park, G., Modak, A., Hogan, N. C., and Hunter, I. W., 2015, "The Effect of Jet Shape on Jet Injection," 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society(EMBC), pp. 7350-7353.
4 Schramm-Baxter, J., and Mitragotri, S., 2004, "Needle-Free Jet Injections: Dependence of Jet Penetration and Dispersion in the Skin on Jet Power," J. Control. Release, Vol. 97(3), pp. 527-535.   DOI
5 Shergold, O. A., Fleck, N. A., and King, T. S., 2006, "The Penetration of a Soft Solid by a Liquid Jet, with Application to the Administration of a Needle-Free Injection," J. Biomech., Vol. 39(14), pp. 2593-2602.   DOI
6 Portaro, R., and Ng, H. D., 2015, "Experiments and Modeling of Air-Powered Needle-Free Liquid Injectors," J. Med. Biol. Eng., Vol. 35(5), pp. 685-695.   DOI
7 Nakayama, H., Portaro, R., Kiyanda, C. B., and NG, H. D., 2016, "CFD Modeling of High Speed(F1) Liquid Jets From an Air-Powered Needle-Free Injection System," J. Mech. Med. Biol., Vol. 16(4), p. 1650045.   DOI
8 Chen, A. I., Balter, M. L., Chen, M. I., Gross, D., Alam, S. K., Maguire, T. J., and Yarmush, M. L., 2016, "Multilayered Tissue Mimicking Skin and Vessel Phantoms with Tunable Mechanical, Optical, and Acoustic Properties," Med. Phys., Vol. 43(6), pp. 3117-3131.   DOI
9 Bader, D. L., and Bowker, P., 1983, "Mechanical Characteristics of Skin and Underlying Tissues in vivo," Biomaterials, Vol. 4(4), pp. 305-308.   DOI
10 Schramm-Baxter, J., Katrencik, J., and Mitragotri, S., 2004, "Jet Injection into Polyacrylamide Gels: Investigation of Jet Injection Mechanics," J. Biomech., Vol. 37(8), pp. 1181-1188.   DOI
11 Schramm, J., and Mitragotri, S., 2002, "Transdermal Drug Delivery by Jet Injectors: Energetics of Jet Formation and Penetration," Pharm. Res., Vol. 19(11), pp. 1673-1679.   DOI
12 Kwon, T. R., Seok, J., Jang, J. H., Kwon, M. K., Oh, C. T., Choi, E. J., Hong, H. K., Choi, Y. S., Bae, J., and Kim, B. J., 2016, "Needle-Free Jet Injection of Hyaluronic Acid Improves Skin Remodeling in a Mouse Model," Eur. J. Pharm. Biopharm., Vol. 105, pp. 69-74.   DOI
13 Kale, T. R., 2014, "Needle Free Injection Technology - An Overview," Inov. Pharm., Vol. 5(1), p. 10.
14 Kumar, R. B., 2012, "Needle-Free Injection System," Pharma J., Vol. 1(9), pp. 57-72.
15 Arenas da Silva, L. F., Schober, L., Sloff, M., Traube, A., Hart, M. L., Feitz, W. F. J., and Stenzl, A., 2015, "New Technique for Needle-Less Implantation of Eukaryotic Cells," Cytotherapy, Vol. 17(11), pp. 1655-1661.   DOI
16 Jagadeesh, G., Prakash, G. D., Rakesh, S. G., Allam, U. S., Krishna, M. G., Eswarappa, S. M., and Chakravortty, D., 2011, "Needleless Vaccine Delivery Using Micro-Shock Waves," Clin. Vaccine Immunol., Vol. 18(4), pp. 539-545.   DOI
17 Levenberg, A., Halachmi, S., Arad-Cohen, A., Ad-El, D., Cassuto, D., and Lapidoth, M., 2010, "Clinical Results of Skin Remodeling Using a Novel Pneumatic Technology," Int. J. Dermatol., Vol. 49(12), pp. 1432-1439.   DOI
18 Seok, J., Oh, C. T., Kwon, H. J., Kwon, T. R., Choi, E. J., Choi, S. Y., Mun, S. K., Han, S. H., Kim, B. J., and Kim, M. N., 2016, "Investigating Skin Penetration Depth and Shape Following Needle-Free Injection at Different Pressures: A Cadaveric Study," Lasers Surg. Med., Vol. 48(6), pp. 624-628.   DOI
19 Peters, I. R., Tagawa, Y., Oudalov, N., Sun, C., Prosperetti, A., Lohse, D., and van der Meer, D., 2013, "Highly Focused Supersonic Microjets: Numerical Simulations," J. Fluid Mech., Vol. 719, pp. 587-605.   DOI
20 Schoubben, A., Cavicchi, A., Barberini, L., Faraon, A., Berti, M., Ricci, M., Blasi, P., and Postrioti, L., 2015, "Dynamic Behavior of a Spring-Powered Micronozzle Needle-Free Injector," Int. J. Pharm., Vol. 491(1-2), pp. 91-98.   DOI
21 Taberner, A., Hogan, N. C., and Hunter, I. W., 2012, "Needle-Free Jet Injection Using Real-Time Controlled Linear Lorentz-Force Actuators," Med. Eng. Phys., Vol. 34(9), pp. 1228-1235.   DOI
22 Tagawa, Y., Oudalov, N., El Ghalbzouri, a, Sun, C., and Lohse, D., 2013, "Needle-Free Injection into Skin and Soft Matter with Highly Focused Microjets," Lab Chip, Vol. 13(7), pp. 1357-63.   DOI