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http://dx.doi.org/10.5407/JKSV.2018.16.1.015

Microfluidic Device for Ultrasound Image Analysis based on 3D Printing  

Kang, Dongkuk (School of Mechanical Engineering, Pusan National University)
Hong, Hyeonji (School of Mechanical Engineering, Pusan National University)
Yeom, Eunseop (School of Mechanical Engineering, Pusan National University)
Publication Information
Journal of the Korean Society of Visualization / v.16, no.1, 2018 , pp. 15-20 More about this Journal
Abstract
For the measurement of biophysical properties related with cardiovascular diseases (CVD), various microfluidic devices were proposed. However, many devices were monitored by optical equipment. Ultrasound measurement to quantify the biophysical properties can provide new insights to understand the cardiovascular diseases. This study aims to check feasibility of microfluidic device for ultrasound image analysis based on 3D printer. To facilitate acoustic transmission, agarose solution is poured around 3D mold connected with holes of the acrylic box. By applying speckle image velocimetry(SIV) technique, flow information in the bifurcated channel was estimated. Considering that ultrasound signal amplitude is determined by red blood cell (RBC) aggregation, RBC aggregation in the bifurcated channel can be estimated through the analysis of ultrasound signal. As examples of microfluidic device which mimic the CVD model, velocity fields in microfluidic devices with stenosis and aneurysm were introduced.
Keywords
Ultrasound Imaging; 3D Printing; Microfluidic Device;
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