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Hepatic Response in Cytochrome P45O and De-alkylase Activity of Olive Flounder (Paralichthys olivaceus) Exposed to Water-borne Phenanthrene  

Jee, Jung-Hoon (Department of Aquatic Life Medicine, Pukyong National University)
Park, Dae-Kuk (Department of Aquatic Life Medicine, Pukyong National University)
Kang, Ju-Chan (Department of Aquatic Life Medicine, Pukyong National University)
Publication Information
Journal of Aquaculture / v.16, no.2, 2003 , pp. 99-103 More about this Journal
Abstract
Olive flounder (Paralichthys olivaceus) was exposed to water-borne phenanthrene for 4 weeks. After the exposure for 2-weeks, hepatic cytochrome P450 contents were significantly elevated. Induction of hepatic ethoxy resorufin-O-deethylase (PROD) activity was significantly increased in flounders treated with 1.0 and 2.0 $\mu$M phenanthrene, compared to untreated group and 0.5 $\mu$M treated group. However, there were no significant changes in pentoxyresorufin-O-deethylase (PROD) activity in hepatic microsome of all the phenanthrene-treated groups, compared to the untreated group. Phenanthrene has the potential to induce cytochrome P450 and EROD enzyme of the olive flounder.
Keywords
Paralichthys olivaceus; Phenanthrene; CYP450; EROD; PROD;
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Times Cited By KSCI : 1  (Citation Analysis)
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