Browse > Article
http://dx.doi.org/10.7842/kigas.2021.25.6.29

A Study on Prevention of Fire Accidents by Splash Filling in the Filtration Process of Pharmaceutical Companies  

Kim, Sang Gil (Dept. of Safety Engineering, Korea National University of Trans)
Lee, Dae Joon (Dept. of Safety Engineering, Korea National University of Trans)
Yang, Seung Bok (Dept. of Safety Engineering, Korea National University of Trans)
Rhim, Jong Guk (Dept. of Safety Engineering, Korea National University of Trans)
Publication Information
Journal of the Korean Institute of Gas / v.25, no.6, 2021 , pp. 29-34 More about this Journal
Abstract
Flammable substances are often present in the raw materials of pharmaceutical products manufactured by pharmaceutical companies. In this case, an excessive amount of flammable substances is added to make an intermediate, and flammable substances that do not participate in the reaction are removed through filtration and drying steps. In addition, the flammable liquid separated in the filtration process is accumulated in the form of splash filling in the filtrate container. In this case, vapor and mist of flammable liquid are generated, which lowers the lower limit of explosion and minimum ignition energy, and increases the risk of fire and explosion due to complex charging. In this study, by analyzing fire accidents that occurred during the recent filtration process of pharmaceutical companies, it is proposed to prevent static electricity accumulation by measures of nitrogen supply facilities, capacity improvement, conductive filter fabric and so on.
Keywords
splash filling; filtration; drying steps; pharmaceutical;
Citations & Related Records
연도 인용수 순위
  • Reference
1 KOSHA GUIDE P-80, "Technical Guidelines for Inert gas Substitution", KOSHA, (2011)
2 Kim, S. G., and Rhim, J.K., "Accident Analysis by Type of Electrostatic Discharge in Batch Process", Korea National University of Transportation, (2018)
3 Notice of Ministry of Employment and Labor 2020-55, "Regulations on Submission, evaluation, and implementation status of PSM reports", MOEL, (2020)
4 NFPA77, "Recommended Practice on Static Electricity ", 8,-9 (2000)
5 KOSHA GUIDE E-89, "Technical guidelines for Preventing Static Electricity", KOSHA, (2018)
6 Kim, S. R., and Kim, S. G., and Kim, J.D., and Rhim, J.K., "A Study on the Prevention Measures against Fire and Explosion Accidents during Splash Filling in Batch Process ", KIGAS,1,33-39(2020)
7 RR980, "Generation of Flammable Mists from high Flashpoint Fluids - HSE", 7-37, (2013)
8 Lee, H. S., and Yoon, H. C., "A study on the Rupture Disk Design and Application at the Two Phase Flow by Runaway Reaction at Batch Reactor", KIGAS, 3, 2-2(2017)
9 KOSHA GUIDE E-171, "Technical Guidelines on the Prevention of Electrostatic Fire Accidents due to Splash Filling", KOSHA, (2018)
10 Applied Process Design For Chemical and Petrochemical Plants, "Purging of Flare Stacks and Vessels/Piping", 534-535 (1999)