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http://dx.doi.org/10.14695/KJSOS.2016.19.4.111

Electrophysiological Analysis in Diabetic Patients with Abnormal Sensation and Pain  

Yang, Jiwon (Department of Neurology, Gachon University Gil Medical Center)
Lee, Yeong-Bae (Department of Neurology, Gachon University Gil Medical Center)
Publication Information
Science of Emotion and Sensibility / v.19, no.4, 2016 , pp. 111-118 More about this Journal
Abstract
Patients with type 2 diabetes mellitus can complain of abnormal sensation and pain which derived from the peripheral nerve damage. Various words used to be describe abnormal sense and pain, such as sharp, hot, dull, cold, sensitive, and itch. To diagnose diabetic peripheral neuropathy, several screening instruments (Neuropathic Pain Scale, NPS; Michigan Neuropathy Screening Instruments, MNSI) and electrophysiological study can be used. In this study, we aim to analyze and compare the clinical and electrophysiological characteristics of 11 patients with diabetes mellitus and abnormal sense/pain (Disease Group, DG) and 10 patients with diabetes mellitus and normal sense (Control Group, CG). In addition, we aim to reveal correlation between NPS subscore and electrophysiological parameters. As a result, the scores of NPS and MNSI in DG were significantly higher. In nerve conduction study, median motor nerve and peroneal nerve showed significant functional change. Also, median motor nerve, posterior tibial nerve and sural nerve showed negative correlation as NPS subscore increased. These results mean increased pain can be associated with abnormal nerve function. It needs to be further explored for larger size of subjects to get confirmative results.
Keywords
Diabetes Mellitus; Neuropathy; Abnormal Sense; Pain; Electrophysiological Study;
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Times Cited By KSCI : 2  (Citation Analysis)
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1 Executive Summary: Standards of medical care in diabetes--2012. (2011). Diabetes Care, 35(Supplement_1), S4-S10.
2 Boureau, F., Dubrere, J., & Luu, M. (1990). Study of verbal description in neuropathic pain. Pain, 41, S465.
3 Dyck, P., Albers, J., Andersen, H., Arezzo, J., Biessels, G., & Bril, V. et al. (2011). Diabetic polyneuropathies: update on research definition, diagnostic criteria and estimation of severity. Diabetes/Metabolism Research And Reviews, 27(7), 620-628.   DOI
4 Feldman, E., Stevens, M., Thomas, P., Brown, M., Canal, N., & Greene, D. (1994). A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy. Diabetes Care, 17(11), 1281-1289.   DOI
5 Fullerton, B., Jeitler, K., Seitz, M., Horvath, K., Berghold, A., & Siebenhofer, A. (2014). Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus. Cochrane Database Of Systematic Review, 14(2), CD009122.
6 Galer, B. & Jensen, M. (1997). Development and preliminary validation of a pain measure specific to neuropathic pain: The Neuropathic Pain Scale. Neurology, 48(2), 332-338.   DOI
7 Ha, K. & Kim, D. (2015). Trends in the diabetes epidemic in korea. Endocrinol Metab, 30(2), 142. http://dx.doi.org/10.3803/enm.2015.30.2.142   DOI
8 Lee, S. & Bae, S. (2005). New trend of pain evaluation by brain imaging devices. Science of Emotion and Sensibility, 8(4), 365-374.
9 Hink, U., Li, H., Mollnau, H., Oelze, M., Matheis, E., & Hartmann, M. et al. (2001). Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circulation Research, 88(2), e14-e22.   DOI
10 Kwak, Y., Won, R., Lee, H., & Lee, B. (2010). Pain, acupuncture and brain imaging. Science of Emotion and Sensibility, 13(3), 551-558.
11 Oh, S. (2003). Clinical electromyography. 3rd Ed. Philadelphia: Lippincott Williams & Wilkins. 57-67.
12 Partanen, J., Niskanen, L., Lehtinen, J., Mervaala, E., Siitonen, O., & Uusitupa, M. (1995). Natural history of peripheral neuropathy in patients with non-insulin-dependent diabetes mellitus. New England Journal Of Medicine, 333(2), 89-94.   DOI
13 Won, J. & Park, T. (2016). Recent advances in diagnostic strategies for diabetic peripheral neuropathy. Endocrinol Metab, 31(2), 230.   DOI
14 Young, M., Boulton, A., Macleod, A., Williams, D., & Sonksen, P. (1993). A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia, 36(2), 150-154.   DOI
15 Yang, C., Lin, C., Li, C., Liu, C., Lin, W., & Hwang, K. et al. (2015). Cardiovascular risk factors increase the risks of diabetic peripheral neuropathy in patients with type 2 diabetes mellitus. Medicine, 94(42), e1783.   DOI