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http://dx.doi.org/10.9766/KIMST.2017.20.6.781

A New Method for Synthesizing Tetrazoles from Secondary Amines using Trichloroacetonitrile  

Oh, Su-Jin (The 4th Research and Development Institute, Agency for Defense Development)
Publication Information
Journal of the Korea Institute of Military Science and Technology / v.20, no.6, 2017 , pp. 781-787 More about this Journal
Abstract
A new method for synthesizing the tetrazole derivatives from secondary amines through cyanation/tetrazolation has been developed. Trichloroacetonitrile is used as the cyano source to synthesize N-nitrile instead of highly toxic and expensive cyanogen bromide. In this protocol, the reaction of secondary amines with various substituents proceed smoothly, and the desired tetrazole derivatives are obtained directly in fair to high yields without isolation of intermediate cyanamides.
Keywords
Trichloroacetonitrile; Tetrazole Derivatives; Secondary Amines; High-Energy Density Materials;
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