A Multi-chambered Single Autoinjector and KMARK-1 Containing Atropine and 2-PAM: Comparative Bioavailability Studies Using Single Intramuscular Injection with Beagle Dogs |
Lee, Keunwoo
(Samyang Chemical Research Institute of Technology Development)
An, Seoyeon (Samyang Chemical Research Institute of Technology Development) Kwon, Taekeun (Samyang Chemical Research Institute of Technology Development) Jung, Inhong (Samyang Chemical Research Institute of Technology Development) Kim, Dongyeon (Samyang Chemical Research Institute of Technology Development) |
1 | Shih, T. M., "Time Course Effects of Soman on Acetylcholine and Choline Levels in Six Discrete Areas of the Rat Brain," Psychopharmacology, Vol. 78, pp. 170-175, 1982. DOI |
2 | Lim, D. K., Lee, Porter, A. B., Hoskins, B. Ho, I. K., "Changes in ACh Levels in the Rat Brain During Subacute Administration of Diisopropylfluorophosphate," Toxicol. Appl. Pharmacol., Vol. 90, pp. 477-489, 1987. DOI |
3 | Marino MT, Schuster BG, Brueckner RP, Lin E, Kaminskis A, Lasseter KC. "Population pharmacokinetics and pharmacodynamics of pyridostigmine Bromide for Prophylaxis Against Nerve Agents in Humans," J. Clin. Pharmacol., Vol. 38, pp. 227-235, 1998. DOI |
4 | Dunn, M. A. Sidell, F. R., "Progress in Medical Defence Against Nerve Agents," JAMA, Vol. 262, pp. 649-652, 1989. DOI |
5 | Loomis, T. A., Salafsky, B., "Antidotal Action of Pyridinium Oximes in Anticholinesterase Poisoning ; Comparative Effects of Soman, Sarin, and Neostigmine on Neuromuscular Function," Toxicol. Appl. Pharmacol., Vol. 5, pp. 685-701, 1963. DOI |
6 | Berman, H. A., Decker, M. M., "Kinetic, Equilibrium, and Spectroscopic Studies on Dealkylation("aging") of Alkyl Organophosphonyl Acetylcholinesterase," J. Biol. Chem., Vol. 261, pp. 10646-10652, 1986. |
7 | KMARK-1, http://www.samyangchem.com |
8 | ATNAA, http://meridianmeds.com |
9 | ATNAA, "Clinical Pharmacology and Biopharmaceutics review(s)," http://www.fda.gov |
10 | Keunwoo Lee, Seoyeon An and Byungil Hur, “A Case Study on the FDA Approval of Medical Treatments against Nerve Agent Poisoning,” Journal of the Korea Institute of Military Science and Technology, Vol. 19, No. 1, pp. 119-126, 2016. DOI |
11 | "Guideline on Bioanalytical Method Validation," Ministry of Food and Drug Safety, 2013. |
12 | Seoyeon An, Keunwoo Lee, Taekeun Kwon and Dongyeon Kim, “A Multi-chambered Single Autoinjector: Design and Performance Assesment,” Journal of the Korea Institute of Military Science and Technology, Vol. 20, No. 2, pp. 170-180, 2017. DOI |
13 | "Standard on Pharmaceutical Equivalence Study," Ministry of Food and Drug Safety, 2016. |