Browse > Article
http://dx.doi.org/10.3347/kjp.2022.60.1.65

Severe Fever with Thrombocytopenia Syndrome Virus in Ticks in the Republic of Korea  

Kang, Jun-Gu (Korea Zoonosis Research Institute, Jeonbuk National University)
Cho, Yoon-Kyoung (Laboratory of Veterinary Internal Medicine, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University)
Jo, Young-Sun (Laboratory of Veterinary Internal Medicine, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University)
Han, Sun-Woo (Laboratory of Veterinary Internal Medicine, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University)
Chae, Jeong-Byoung (Laboratory of Veterinary Internal Medicine, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University)
Park, Jung-Eun (National Institute of Wildlife Disease Control and Prevention)
Jeong, Hyesung (National Institute of Wildlife Disease Control and Prevention)
Jheong, Weon-Hwa (National Institute of Wildlife Disease Control and Prevention)
Chae, Joon-Seok (Laboratory of Veterinary Internal Medicine, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University)
Publication Information
Parasites, Hosts and Diseases / v.60, no.1, 2022 , pp. 65-71 More about this Journal
Abstract
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a zoonotic, tick-borne RNA virus of the genus Bandavirus (Family Phenuiviridae), mainly reported in China, Japan, and the Republic of Korea (Korea). For the purpose of this study, a total of 3,898 adult and nymphal ticks of species Haemaphysalis longicornis (94.2%), Haemaphysalis flava (5.0%), Ixodes nipponensis (0.8%), and 1 specimen of Ixodes ovatus, were collected from the Deogyusan National Park, Korea, between April 2016 and June 2018. A single-step reverse transcriptase-nested PCR was performed, targeting the S segment of the SFTSV RNA. Total infection rate (IR) of SFTSV in individual ticks was found to be 6.0%. Based on developmental stages, IR was 5.3% in adults and 6.0% in nymphs. The S segment sequences obtained from PCR were divided into 17 haplotypes. All haplotypes were phylogenetically clustered into clades B-2 and B-3, with 92.7% sequences in B-2 and 7.3% in B-3. These observations indicate that the Korean SFTSV strains were closer to the Japanese than the Chinese strains. Further epidemiological studies are necessary to better understand the characteristics of the Korean SFTSV and its transmission cycle in the ecosystem.
Keywords
Haemaphysalis longicornis; severe fever with thrombocytopenia syndrome virus; tick; National Park; vegetation; Korea;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Win AM, Nguyen YTH, Kim Y, Ha NY, Kang JG, Kim H, San B, Kyaw O, Htike WW, Choi DO, Lee KH, Cho NH. Genotypic heterogeneity of Orientia tsutsugamushi in scrub typhus patients and thrombocytopenia syndrome co-infection, Myanmar. Emerg Infect Dis 2020; 26: 1878-1881. https://doi.org/10.3201/eid2608.200135   DOI
2 Zhuang L, Sun Y, Cui XM, Tang F, Hu JG, Wang LY, Cui N, Yang ZD, Huang DD, Zhang XA, Liu W, Cao WC. Transmission of severe fever with thrombocytopenia syndrome virus by Haemaphysalis longicornis ticks, China. Emerg Infect Dis 2018; 24: 868-871. https://doi.org/10.3201/eid2405.151435   DOI
3 Jung M, Kho JW, Lee WG, Roh JY, Lee DH. Seasonal occurrence of Haemaphysalis longicornis (Acari: Ixodidae) and Haemaphysalis flava, vectors of severe fever with thrombocytopenia syndrome (SFTS) in South Korea. J Med Entomol 2019; 56: 1139-1144. https://doi.org/10.1093/jme/tjz033   DOI
4 Luo LM, Zhao L, Wen HL, Zhang ZT, Liu JW, Fang LZ, Xue ZF, Ma DQ, Zhang XS, Ding SJ, Lei XY, Yu XJ. Haemaphysalis longicornis ticks as reservoir and vector of severe fever with thrombocytopenia syndrome virus in China. Emerg Infect Dis 2015; 21: 1770-1776. https://doi.org/10.3201/eid2110.150126   DOI
5 Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Wilm A, Lopez R, Thompson JD, Gibson TJ, Higgins DG. Clustal W and Clustal X version 2.0. Bioinformatics 2007; 23: 2947-2948. https://doi.org/10.1093/bioinformatics/btm404   DOI
6 Park SW, Song BG, Shin EH, Yun SM, Han MG, Park MY, Park C, Ryou J. Prevalence of severe fever with thrombocytopenia syndrome virus in Haemaphysalis longicornis ticks in South Korea. Ticks Tick Borne Dis 2014; 5: 975-977. https://doi.org/10.1016/j.ttbdis.2014.07.020   DOI
7 Lee J, Moon K, Kim M, Lee WG, Lee HI, Park JK, Kim YH. Seasonal distribution of Haemaphysalis longicornis (Acari: Ixodidae) and detection of SFTS virus in Gyeongbuk Province, Republic of Korea, 2018. Acta Trop 2021; 221: 106012. https://doi.org/10.1016/j.actatropica.2021.106012   DOI
8 Wang S, Li J, Niu G, Wang X, Ding S, Jiang X, Li C, Zhang Q, Liang M, Bi Z, Li D. SFTS virus in ticks in an endemic area of China. Am J Trop Med Hyg 2015; 92: 684-689. https://doi.org/10.4269/ajtmh.14-0008   DOI
9 Lee SY, Kang JG, Jeong HS, Kim WM, Son KD, Kim JS, Oh SS, Cho YK, Jheong WH, Chae JS. Complete genome sequences of two severe fever with thrombocytopenia syndrome virus strains isolated from a human and a dog in the Republic of Korea. Microbiol Resour Announc 2019; 8: e01695-18. https://doi.org/10.1128/MRA.01695-18   DOI
10 Kim KH, Yi J, Kim G, Choi SJ, Jun KI, Kim NH, Choe PG, Kim NJ, Lee JK, Oh MD. Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg Infect Dis 2013; 19: 1892-1894. https://doi.org/10.3201/eid1911.130792   DOI
11 Nam SJ, Oh YI, Kim HJ, Cheon DS, Noh SJ, Hong YJ. Unusual case of severe fever with thrombocytopenia syndrome showing clinical manifestations in a companion dog. Vet Med Sci 2020; 6: 353-358. https://doi.org/10.1002/vms3.261   DOI
12 Kim-Jeon MD, Jegal S, Jun H, Jung H, Park SH, Ahn SK, Lee J, Gong YW, Joo K, Kwon MJ, Roh JY, Lee WG, Bahk YY, Kim TS. Four year surveillance of the vector hard ticks for SFTS, Ganghwa-do, Republic of Korea. Korean J Parasitol 2019; 57: 691-698. https://doi.org/10.3347/kjp.2019.57.6.691   DOI
13 Takahashi T, Maeda K, Suzuki T, Ishido A, Shigeoka T, Tominaga T, Kamei T, Honda M, Ninomiya D, Sakai T, Senba T, Kaneyuki S, Sakaguchi S, Satoh A, Hosokawa T, Kawabe Y, Kurihara S, Izumikawa K, Kohno S, Azuma T, Suemori K, Yasukawa M, Mizutani T, Omatsu T, Katayama Y, Miyahara M, Ijuin M, Doi K, Okuda M, Umeki K, Saito T, Fukushima K, Nakajima K, Yoshikawa T, Tani H, Fukushi S, Fukuma A, Ogata M, Shimojima M, Nakajima N, Nagata N, Katano H, Fukumoto H, Sato Y, Hasegawa H, Yamagishi T, Oishi K, Kurane I, Morikawa S, Saijo M. The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan. J Infect Dis 2014; 209: 816-827. https://doi.org/10.1093/infdis/jit603   DOI
14 Daengnoi C, Ongkittikul S, Watanawong R, Rompho P. Severe fever with thrombocytopenia syndrome virus: the first case report in Thailand. Bangk Med J 2020; 16: 204. https://doi.org/10.31524/bkkmedj.2020.22.001   DOI
15 Zohaib A, Zhang J, Saqib M, Athar MA, Hussain MH, Chen J, Sial AU, Tayyab MH, Batool M, Khan S, Luo Y, Waruhiu C, Taj Z, Hayder Z, Ahmed R, Siddique AB, Yang X, Qureshi MA, Ujjan IU, Lail A, Khan I; Sajjad-Ur-Rahman, Zhang T, Deng F, Shi Z, Shen S Serologic evidence of severe fever with thrombocytopenia syndrome virus and related viruses in Pakistan. Emerg Infect Dis 2020; 26: 1513-1516. https://doi.org/10.3201/eid2607.190611   DOI
16 Yamaguti N, Tipton VJ, Keegan HL, Toshioka S. Ticks of Japan, Korea, and the Ryukyu islands. Brigham Young Univ Sci Bull Biol Ser 1971; 15: 1-226. https://scholarsarchive.byu.edu/byuscib/vol15/iss1/1
17 Kim JY, Jung M, Kho JW, Song H, Moon K, Kim YH, Lee DH. Characterization of overwintering sites of Haemaphysalis longicornis (Acari: Ixodidae) and tick infection rate with severe fever with thrombocytopenia syndrome virus from eight provinces in South Korea. Ticks Tick Borne Dis 2020; 11: 101490. https://doi.org/10.1016/j.ttbdis.2020.101490   DOI
18 Kumar S, Stecher G, Tamura K. MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol Biol Evol 2016; 33: 1870-1874. https://doi.org/10.1093/molbev/msw054   DOI
19 Zheng H, Yu Z, Zhou L, Yang X, Liu J. Seasonal abundance and activity of the hard tick Haemaphysalis longicornis (Acari: Ixodidae) in North China. Exp Appl Acarol 2012; 56: 133-141. https://doi.org/10.1007/s10493-011-9505-x   DOI
20 Gray JS, Kahl O, Lane RS, Levin ML, Tsao JI. Diapause in ticks of the medically important Ixodes ricinus species complex. Ticks Tick Borne Dis 2016; 7: 992-1003. https://doi.org/10.1016/j.ttbdis.2016.05.006   DOI
21 Peng SH, Yang SL, Tang SE, Wang TC, Hsu TC, Su CL, Chen MY, Shimojima M, Yoshikawa T, Shu PY. Human case of severe fever with thrombocytopenia syndrome virus infection, Taiwan, 2019. Emerg Infect Dis 2020; 26: 1612-1614. https://doi.org/10.3201/eid2607.200104   DOI
22 Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, Sun YL, Zhang L, Zhang QF, Popov VL, Li C, Qu J, Li Q, Zhang YP, Hai R, Wu W, Wang Q, Zhan FX, Wang XJ, Kan B, Wang SW, Wan KL, Jing HQ, Lu JX, Yin WW, Zhou H, Guan XH, Liu JF, Bi ZQ, Liu GH, Ren J, Wang H, Zhao Z, Song JD, He JR, Wan T, Zhang JS, Fu XP, Sun LN, Dong XP, Feng ZJ, Yang WZ, Hong T, Zhang Y, Walker DH, Wang Y, Li DX. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 2011; 364: 1523-1532. https://doi.org/10.1056/NEJMoa1010095   DOI
23 Lin TL, Ou SC, Maeda K, Shimoda H, Chan JP, Tu WC, Hsu WL, Chou CC. The first discovery of severe fever with thrombocytopenia syndrome virus in Taiwan. Emerg Microbes Infect 2020; 9: 148-151. https://doi.org/10.1080/22221751.2019.1710436   DOI
24 Jo YS, Kang JG, Chae JB, Cho YK, Shin JH, Jheong WH, Chae JS. Prevalence of severe fever with thrombocytopenia syndrome virus in ticks collected from national parks in Korea. Vector Borne Zoonotic Dis 2019; 19: 284-289. https://doi.org/10.1089/vbz.2018.2338   DOI
25 Seo JW, Han SY, Sung SH, Jung EY, Kim JH, Lee SJ, Yoo SS. Survey on tick distribution and tick-borne pathogens in Daejeon and adjacent areas in South Korea. Ticks Tick Borne Dis 2021; 12: 101711. https://doi.org/10.1016/j.ttbdis.2021.101711   DOI
26 Yun SM, Park SJ, Kim YI, Park SW, Yu MA, Kwon HI, Kim EH, Yu KM, Jeong HW, Ryou J, Lee WJ, Jee Y, Lee JY, Choi YK. Genetic and pathogenic diversity of severe fever with thrombocytopenia syndrome virus (SFTSV) in South Korea. JCI Insight 2020; 5: e129531. https://doi.org/10.1172/jci.insight.129531   DOI
27 Walker PJ, Siddell SG, Lefkowitz EJ, Mushegian AR, Adriaenssens EM, Alfenas-Zerbini P, Davison AJ, Dempsey DM, Dutilh BE, Garcia ML, Harrach B, Harrison RL, Hendrickson RC, Junglen S, Knowles NJ, Krupovic M, Kuhn JH, Lambert AJ, Lobocka M, Nibert ML, Oksanen HM, Orton RJ, Robertson DL, Rubino L, Sabanadzovic S, Simmonds P, Smith DB, Suzuki N, Van Dooerslaer K, Vandamme AM, Varsani A, Zerbini FM. Changes to virus taxonomy and to the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2021). Arch Virol 2021; 166: 2633-2648. https://doi.org/10.1007/s00705-021-05156-1   DOI
28 Matsuno K, Nonoue N, Noda A, Kasajima N, Noguchi K, Takano A, Shimoda H, Orba Y, Muramatsu M, Sakoda Y, Takada A, Minami S, Une Y, Morikawa S, Maeda K. Fatal tickborne phlebovirus infection in captive cheetahs, Japan. Emerg Infect Dis 2018; 24: 1726-1729. https://doi.org/10.3201/eid2409.171667   DOI
29 Matsuu A, Momoi Y, Nishiguchi A, Noguchi K, Yabuki M, Hamakubo E, Take M, Maeda K. Natural severe fever with thrombocytopenia syndrome virus infection in domestic cats in Japan. Vet Microbiol 2019; 236: 108346. https://doi.org/10.1016/j.vetmic.2019.06.019   DOI
30 Han SW, Kang JG, Byeon AR, Cho YK, Choi KS, Chae JS. Severe fever with thrombocytopenia syndrome in canines from the Republic of Korea. Ticks Tick Borne Dis 2020; 11: 101454. https://doi.org/10.1016/j.ttbdis.2020.101454   DOI
31 Tran XC, Yun Y, Le Van An SH, Thao NT, Man PK, Yoo JR, Heo ST, Cho NH, Lee KH. Endemic severe fever with thrombocytopenia syndrome, Vietnam. Emerg Infect Dis 2019; 25: 1029-1031. https://doi.org/10.3201/eid2505.181463   DOI