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http://dx.doi.org/10.3347/kjp.2021.59.4.415

Seroprevalence of Plasmodium vivax Circumsporozoite Protein Antibody in High-Risk Malaria Areas in Korea  

Lee, Jinyoung (Department of Parasitology and Tropical Medicine & Global Resource Bank of Parasitic Protozoa Pathogens, Inha University School of Medicine)
Jin, Kyoung (Korea Health Evaluation Institute, Sahmyook University)
Ahn, Seong Kyu (Infectious Diseases Investigation Division, Jeonnam Institute of Public Health and Environment)
Lee, Sung-Keun (Department of Pharmacology, Inha University School of Medicine)
Kwon, Hyung Wook (Department of Life Sciences, Incheon National University)
Na, Byoung-Kuk (Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, and Institute of Health Sciences, Gyeongsang National University College of Medicine)
Kim, Tong-Soo (Department of Parasitology and Tropical Medicine & Global Resource Bank of Parasitic Protozoa Pathogens, Inha University School of Medicine)
Publication Information
Parasites, Hosts and Diseases / v.59, no.4, 2021 , pp. 415-419 More about this Journal
Abstract
The circumsporozoite protein (CSP) of Plasmodium spp. is a diagnostic antigen and useful biomarker for monitoring short-term/seasonal changes to malaria transmission. Using P. vivax CSP antibody ELISA, epidemiological characteristics were analyzed in the residents of Ganghwa, Cheorwon, Paju, and Goseong from 2017 to 2018. In Ganghwa and Cheorwon, 1.6% and 1.2% of residents, respectively, were PvCSP-antibody-positive in 2018, which indicates a decrease of 0.4% in the positive rate compared to 2017. The annual parasite incidence (API) in Ganghwa and Cheorwon was 24.9 and 10.5 in 2017 and 20.3 and 10.7 in 2018, respectively. Although the changes were not significant, the API in Ganghwa decreased slightly by 4.5 in 2018 compared to the previous year. In Paju and Goseong, 3.9% and 2.0% of residents were positive for the PvCSP antibody. The API in Paju was 13.1 in 2017 and 16.0 in 2018, although no malaria patients were reported for the 2 years. Therefore, the results suggest that PvCSP is a useful antigen for confirming initial malaria infection. Additionally, considering that the antibody is relatively transient, it can be employed for sero-epidemiological studies to determine the extent of malaria transmission in the current year.
Keywords
Plasmodium vivax; vivax malaria; circumsporozoite protein; elimination study; Korea;
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1 Cho PY, Lee SW, Ahn SK, Kim JS, Cha SH, Na BK, Park YK, Lee SK, Lee WJ, Nam HW, Hong SJ, Pak JH, Kang YJ, Sohn Y, Bahk YY, Cho HI, Kim TS, Lee HW. Evaluation of circumsporozoite protein of Plasmodium vivax to estimate its prevalence in the Republic of Korea: an observational study of incidence. Malar J 2013; 12: 448. https://doi.org/10.1186/1475-2875-12-448   DOI
2 Snounou G, Pinheiro L, Goncalves A, Fonseca L, Dias F, Brown KN, do Rosario VE. The importance of sensitive detection of malaria parasites in the human and insect hosts in epidemiological studies, as shown by the analysis of field samples from Guinea Bissau. Trans R Soc Trop Med Hyg 1993; 87: 649-653. https://doi.org/10.1016/00359203(93)90274-t   DOI
3 Wijesundera MD, Peiris JSM, Ariyaratne YG, Verdini AS, Pessi A, Giudice GD. Antibodies to Plasmodium falciparum sporozoites following a malarial outbreak in a non-endemic area of Sri Lanka. Trans R Soc Trop Med Hyg 1990; 84: 35-39. https://doi.org/10.1016/0035-9203(90)90372-l   DOI
4 Kho WG, Jang JY, Hong ST, Lee HW, Lee WJ, Lee JS. Border malaria characters of reemerging vivax malaria in the Republic of Korea. Korean J Parasitol 1999; 37: 71-76. https://doi.org/10.3347/kjp.1999.37.2.71   DOI
5 Lee JS, Kho WG, Lee HW, Seo M, Lee WJ. Current status of vivax malaria among civilians in Korea. Korean J Parasitol 1998; 36: 241-248. https://doi.org/10.3347/kjp.1998.36.4.241   DOI
6 Brown AE, Webster HK, Krinchal K, Gordon DM, Wirtz RA, Permpanich B. Characteristics of natural antibody responses to the circumsporozoite protein of Plasmodium vivax. Am J Trop Med Hyg 1991; 44: 21-27. https://doi.org/10.4269/ajtmh.1991.44.21   DOI
7 Gordon DM, Cosgriff TM, Schneider I, Wasserman GF, Majarian WR, Hollingdale MR, Chulay JD. Safety and immunogenicity of a Plasmodium vivax sporozoite vaccine. Am J Trop Med Hyg 1990; 42: 527-531. https://doi.org/10.4269/ajtmh.1990.42.527   DOI
8 Hoffman SL, Wistar R Jr, Ballou WR, Hollingdale MR, Wirtz RA, Schneider I, Marwoto HA, Hockmeyer WT. Immunity to malaria and naturally acquired antibodies to the circumsporozoite protein of Plasmodium falciparum. N Engl J Med 1986; 315: 601-606. https://doi.org/10.1056/NEJM198609043151001   DOI
9 Laurens MB. RTS, S/AS01 Vaccine (MosquirixTM): an overview. Hum Vaccin Immunother 2020; 16: 480-489. https://doi.org/10.1080/21645515.2019.1669415   DOI
10 Kusi KA, Bosomprah S, Kyei-Baafour E, Dickson EK, Tornyigah B, Angov E, Dutta S, Dodoo D, Sedegah M, Koram KA. Seropervalence of Antibidoes against Plasmodium falciparum Sporozoite Antigen as Predictive Disease Transmission Markers in an Area Ghana with Seasonal Malaria Transmission. PLoS One 2016; 11: e0167175. https://doi.org/10.1371/journal.pone.0167175   DOI
11 Porter MD, Nicki J, Pool CD, DeBot M, Illam RM, Brando C, Bozick B, De La Vega P, Angra D, Spaccapelo R, Crisanti A, Murphy JR, Bennett JW, Schwenk RJ, Ockenhouse CF, Dutta S. Transgenic parasites stably expressing full-length Plasmodium falciparum circumsporozoite protein as a model for vaccine downselection in mice using sterile protection as an endpoint. Clin Vaccine Immunol 2013; 20: 803-810. https://doi.org/10.1128/CVI.00066-13   DOI
12 Druilhe P, Pradier O, Marc JP, Miltgen F, Mazier D, Parent G. Level of antibodies to Plasmodium falciparum sporozoite surface antigens reflect malaria transmission rates and are persistent in the absence of reinfection. Infect Immun 1986; 53: 393-397. https://doi.org/10.1128/IAI.53.2.393-397   DOI
13 Soh CT, Lee KT, Im KI, Min DY, Ahn MH, Kim JJ, Yong TS. Current status of malaria in Korea. Yonsei Rep Trop Med 1985; 16: 11-18.
14 Cho SY, Kong Y, Park SM, Lee JS, Lim YA, Chae SL, Kho WG, Lee JS, Shim JC, Shin HK. Two vivax malaria cases detected in Korea. Korean J Parasitol 1994; 32: 281-284. https://doi.org/10.3347/kjp.1994.32.4.281   DOI
15 Arnot DE, Barnwell JW, Tam JP, Nussenzweig V, Nussenzweig RS, Enea V. Circumsporozoite protein of Plasmodium vivax gene cloning and characterization of the immunodominant epitope. Science 1985; 230: 815-818. https://doi.org/10.1126/science.2414847   DOI