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http://dx.doi.org/10.3347/kjp.2020.58.2.135

In Vitro Effect of Methanolic Extract of Argemone mexicana against Trichomonas vaginalis  

Elizondo-Luevano, Joel Horacio (Department of Chemistry, College of Biological Sciences, Autonomous University of Nuevo Leon)
Verde-Star, Julia (Department of Chemistry, College of Biological Sciences, Autonomous University of Nuevo Leon)
Gonzalez-Horta, Azucena (Department of Chemistry, College of Biological Sciences, Autonomous University of Nuevo Leon)
Castro-Rios, Rocio (Department of Analytic Chemistry, College of Medicine, Autonomous University of Nuevo Leon)
Hernandez-Garcia, Magda Elizabeth (Northeast Biomedical Research Center, Instituto Mexicano del Seguro Social)
Chavez-Montes, Abelardo (Department of Chemistry, College of Biological Sciences, Autonomous University of Nuevo Leon)
Publication Information
Parasites, Hosts and Diseases / v.58, no.2, 2020 , pp. 135-145 More about this Journal
Abstract
Infections caused by Trichomonas vaginalis in humans are one of the main public health problems caused by sexually transmitted diseases. Objective of this study was to evaluate potential biological activity of the medicinal plant Argemone mexicana (Mexican poppy) on T. vaginalis. Methanolic extracts of the stems and leaves of A. mexicana, and different fractions were prepared with solvents of different polarities. The extracts and functional groups were detected containing sterols, triterpenes, quinones, flavonoids and, alkaloids. Extracts from both the stems and leaves of A. mexicana inhibited the growth of T. vaginalis with half-maximal inhibitory concentration value of 70.6 and 67.2 ㎍/ml, respectively. In the active fractions, the most abundant compounds were berberine and jatrorrhizine, with presumed antiparasitic activity.
Keywords
Argemone mexicana; Trichomonas vaginalis; trichomoniasis; alkaloids;
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