Browse > Article
http://dx.doi.org/10.3347/kjp.2018.56.1.53

Expression Patterns of Host Inflammatory Cytokine Genes during Infestation with Haemaphysalis longicornis, a Zoonotic Vector, in Blood Sucking Periods  

Islam, Mohammad Saiful (Department of Medicine, Surgery & Obstetrics, Faculty of Veterinary and Animal Science, Hajee Mohammad Danesh Science and Technology University)
You, Myung-Jo (Laboratory of Veterinary Parasitology, College of Veterinary Medicine and Bio-safety Research Centre, Chonbuk National University)
Publication Information
Parasites, Hosts and Diseases / v.56, no.1, 2018 , pp. 53-59 More about this Journal
Abstract
Tick saliva is critically important for continuous attachment to the host, blood feeding for days, and transmission of tick-borne pathogens. To characterize the patterns of inflammatory cytokine gene expression during its attachment and blood sucking time, peripheral blood samples of rabbits infested with Haemaphysalis longicornis ticks were collected at different intervals. Blood histamine concentration was evaluated as well as gene encoding IFN-${\gamma}$, TNF-${\alpha}$, IL-2, IL-6, IL-4, and IL-10 were compared with non-infested rabbits. Blood histamine concentration of tick-infested rabbits during fast feeding time was significantly higher than that of non-infested rabbits. In both nymph and adult tick infested rabbits, expression of TNF-${\alpha}$ and IFN-${\gamma}$ genes were decreased significantly (P<0.05), while expression of IL-4, IL-6, and IL-10 were increased 1.3 to 7 folds in adult infested rabbits with the exception of IL-6 that was significantly (P<0.05) decreased in nymph infested rabbits. IL-2 was not expressed in either nymph or adult infestation. H. longicornis saliva is capable of modulate host responses through a complex correlation with histamine and Th1, Th2 mediated cytokines that suppress the inflammatory responses directed toward inflammatory mediators introduced into the host during tick feeding.
Keywords
Haemaphysalis longicornis; cytokine; inflammatory cytokine;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Oliveira CJ, Carvalho WA, Garcia GR, Gutierrez FR, de Miranda Santos IK, Silva JS, Ferreira BR. Tick saliva induces regulatory dendritic cells: MAP-kinases and Toll-like receptor-2 expression as potential targets. Vet Parasitol 2010; 167: 288-297.   DOI
2 Borish L. IL-10: evolving concepts. J Aller Clin Immunol 1998; 101: 293-297.   DOI
3 Bissonnette EY. Histamine inhibits tumor necrosis factor alpha release by mast cells through H2 and H3 receptors. Am J Respir Cell Mol Biol 1996; 14: 620-626.   DOI
4 Wang J, Al-Lamki RS, Zhang H, Kirkiles-Smith N, Gaeta ML, Thiru S, Pober JS, Bradley JR. Histamine antagonizes tumor necrosis factor (TNF) signaling by stimulating TNF receptor shedding from the cell surface and Golgi storage pool. J Biol Chem 2003; 278: 21751-21760.   DOI
5 Godornes C, Leader BT, Molini BJ, Centurion-Lara A, Lukehart SA. Quantitation of rabbit cytokine mRNA by real-time RT-PCR. Cytokine 2007; 38: 1-7.   DOI
6 Tirloni L, Islam MS, Kim TK, Diedrich JK, Yates JR 3rd, Pinto AF, Mulenga A, You MJ, Da Silva Vaz I Jr. Saliva from nymph and adult females of Haemaphysalis longicornis: a proteomic study. Parasit Vectors 2015; 8: 338.   DOI
7 Sher A, Coffman RL. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu Rev Immunol 1992; 10: 385-409.   DOI
8 Raue U, Slivka D, Jemiolo B, Hollon C, Trappe S. Myogenic gene expression at rest and after a bout of resistance exercise in young (18-30 yr) and old (80-89 yr) women. J Appl Physiol 2006; 101: 53-59.   DOI
9 Gillespie RD, Dolan MC, Piesman J, Titus RG. Identification of an IL-2 binding protein in the saliva of the Lyme disease vector tick, Ixodes scapularis. J Immunol 2001; 166: 4319-4326.   DOI
10 Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996; 17: 138-146.   DOI
11 Zeidner N, Dreitz M, Belasco D, Fish D. Suppression of acute Ixodes scapularis-induced Borrelia burgdorferi infection using tumor necrosis factor-alpha, interleukin-2, and interferon-gamma. J Infect Dis 1996; 173: 187-195.   DOI
12 Singh SK, Girschick HJ. Tick-host interactions and their immunological implications in tick-borne diseases. Curr Sci 2003; 85: 1284-1298.
13 Howard M, O'Garra A. Biological properties of interleukin 10. Immunol Today 1992; 13: 198-200.   DOI
14 Kim HY, Mott J, Zhi N, Tajima T, Rikihisa Y. Cytokine gene expression by peripheral blood leukocytes in horses experimentally infected with Anaplasma phagocytophila. Clin Diagn Lab Immunol 2002; 9: 1079-1084.
15 Kemp DH, Bourne A. Boophilus microplus: the effect of histamine on the attachment of cattle-tick larvaestudies in vivo and in vitro. Parasitology 1980; 80: 487-496.   DOI
16 Rick RF. Studies on the reactions of animals to infestation with ticks. VI. Resistance of cattle to infestation with the tick Boophilus microplus (canestrini). Aus J Agri Res 1962; 13: 532-550.   DOI
17 Opal SM, DePalo VA. Anti-inflammatory cytokines. Chest 2000; 117: 1162-1172.   DOI
18 Carvalho-Costa TM, Mendes MT, da Silva MV, da Costa TA, Tiburcio MG, Anhe AC, Rodrigues V Jr, Oliveira CJ. Immunosuppressive effects of Amblyomma cajennense tick saliva on murine bone marrow-derived dendritic cells. Parasit Vectors 2015; 8: 22.   DOI
19 Elenkov IJ, Webster E, Papanicolaou DA, Fleisher TA, Chrousos GP, Wilder RL. Histamine potently suppresses human IL-12 and stimulates IL-10 production via H2 receptors. J Immunol 1998; 161: 2586-2593.
20 Aderka D, Le JM, Vilcek J. IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice. J Immunol 1989; 143: 3517-3523.
21 Kazimirova M, Stibraniova I. Tick salivary compounds: their role in modulation of host defences and pathogen transmission. Front Cell Infect Microbiol 2013; 3: 43.
22 Park IH, Um JY, Cho JS, Lee SH, Lee SH, Lee HM. Histamine promotes the release of interleukin-6 via the H1R/p38 and NFkappaB pathways in nasal fibroblasts. Allergy Asthma Immunol Res 2014; 6: 567-572.   DOI
23 Osna N, Elliott K, Khan MM. The effects of histamine on interferon gamma production are dependent on the stimulatory signals. Int Immunopharmacol 2001; 1: 135-145.   DOI
24 Triggiani M, Gentile M, Secondo A, Granata F, Oriente A, Taglialatela M, Annunziato L, Marone G. Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors. J Immunol 2001; 166: 4083-4091.   DOI
25 Brossard M, Wikel SK. Immunology of interactions between ticks and hosts. Med Vet Entomol 1997; 11: 270-276.   DOI
26 Kopecky J, Kuthejlova M, Pechova J. Salivary gland extract from Ixodes ricinus ticks inhibits production of interferon-gamma by the upregulation of interleukin-10. Parasite Immunol 1999; 21: 351-356.   DOI
27 Wu J, Wang Y, Liu H, Yang H, Ma D, Li J, Li D, Lai R, Yu H. Two immunoregulatory peptides with antioxidant activity from tick salivary glands. J Biol Chem 2010; 285: 16606-16613.   DOI
28 Zeidner NS, Higgs S, Happ CM, Beaty BJ, Miller BR. Mosquito feeding modulates Th1 and Th2 cytokines in flavivirus susceptible mice: an effect mimicked by injection of sialokinins, but not demonstrated in flavivirus resistant mice. Parasite Immunol 1999; 21: 35-44.   DOI
29 Schoeler GB, Manweiler SA, Wikel SK. Cytokine responses of C3H/HeN mice infested with Ixodes scapularis or Ixodes pacificus nymphs. Parasite Immunol 2000; 22: 31-40.
30 Packard KA, Khan MM. Effects of histamine on Th1/Th2 cytokine balance. Int Immunopharmacol 2003; 3: 909-920.   DOI
31 Alexander RB, Ponniah S, Hasday J, Hebel JR. Elevated levels of proinflammatory cytokines in the semen of patients with chronic prostatitis/chronic pelvic pain syndrome. Urology 1998; 52: 744-749.   DOI