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http://dx.doi.org/10.3347/kjp.2016.54.4.407

Characteristics of Imported Malaria and Species of Plasmodium Involved in Shandong Province, China (2012-2014)  

Xu, Chao (Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Shandong Provincial Reference Laboratory for Malaria Diagnosis)
Wei, Qing-Kuan (Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Shandong Provincial Reference Laboratory for Malaria Diagnosis)
Li, Jin (Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Shandong Provincial Reference Laboratory for Malaria Diagnosis)
Xiao, Ting (Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Shandong Provincial Reference Laboratory for Malaria Diagnosis)
Yin, Kun (Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Shandong Provincial Reference Laboratory for Malaria Diagnosis)
Zhao, Chang-Lei (Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Shandong Provincial Reference Laboratory for Malaria Diagnosis)
Wang, Yong-Bin (Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Shandong Provincial Reference Laboratory for Malaria Diagnosis)
Kong, Xiang-Li (Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Shandong Provincial Reference Laboratory for Malaria Diagnosis)
Zhao, Gui-Hua (Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Shandong Provincial Reference Laboratory for Malaria Diagnosis)
Sun, Hui (Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Shandong Provincial Reference Laboratory for Malaria Diagnosis)
Liu, Xin (Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Shandong Provincial Reference Laboratory for Malaria Diagnosis)
Huang, Bing-Cheng (Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Shandong Provincial Reference Laboratory for Malaria Diagnosis)
Publication Information
Parasites, Hosts and Diseases / v.54, no.4, 2016 , pp. 407-414 More about this Journal
Abstract
Malaria remains a serious public health problem in Shandong Province, China; therefore, it is important to explore the characteristics of the current malaria prevalence situation in the province. In this study, data of malaria cases reported in Shandong during 2012-2014 were analyzed, and Plasmodium species were confirmed by smear microscopy and nested-PCR. A total of 374 malaria cases were reported, 80.8% of which were reported from 6 prefectures. Of all cases, P. falciparum was dominant (81.3%), followed by P. vivax (11.8%); P. ovale and P. malariae together accounted for 6.4% of cases. Notably, for the first time since 2012, no indigenous case had been reported in Shandong Province, a situation that continued through 2014. Total 95.2% of cases were imported from Africa. The ratio of male/female was 92.5:1, and 96.8% of cases occurred in people 20-54 years of age. Farmers or laborers represented 77.5% of cases. No significant trends of monthly pattern were found in the reported cases. All patients were in good condition after treatment, except for 3 who died. These results indicate that imported malaria has increased significantly since 2012 in Shandong Province, especially for P. falciparum, and there is an emergence of species diversity.
Keywords
Plasmodium falciparum; Plasmodium vivax; Plasmodium malariae; Plasmodium ovale; imported malaria; microscopy; nested-PCR; China;
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1 Gonzalez JM, Hurtado S, Arevalo-Herrera M, Herrera S. Variants of the Plasmodium vivax circumsporozoite protein (VK210 and VK247) in Colombian isolates. Mem Inst Oswaldo Cruz 2001; 96: 709-712.   DOI
2 del Portillo HA, Longacre S, Khouri E, David PH. Primary structure of the merozoite surface antigen 1 of Plasmodium vivax reveals sequences conserved between different Plasmodium species. Proc Natl Acad Sci USA 1991; 88: 4030-4034.   DOI
3 Zakeri S, Barjesteh H, Djadid ND. Merozoite surface protein-$3{\alpha}$ is a reliable marker for population genetic analysis of Plasmodium vivax. Malar J 2006; 5: 53.   DOI
4 Jelinek T, Proll S, Hess F, Kabagambe G, von Sonnenburg F, Loscher T, Kilian AH. Geographic differences in the sensitivity of a polymerase chain reaction for the detection of Plasmodium falciparum infection. Am J Trop Med Hyg 1996; 55: 647-651.   DOI
5 Yin JH, Yan H, Huang F, Li M, Xiao HH, Zhou SS, Xia ZG. Establishing a China malaria diagnosis reference laboratory network for malaria elimination. Malar J 2015; 14: 40.   DOI
6 Cao J, Sturrock HJ, Cotter C, Zhou S, Zhou H, Liu Y, Tang L, Gosling RD, Feachem RG, Gao Q. Communicating and monitoring surveillance and response activities for malaria elimination: China's "1-3-7" strategy. PLoS Med 2014; 11: e1001642.   DOI
7 The Ministry of Health of the People's Republic of China. Action Plan of China Malaria Elimination (2010-2020). Available at: http://www.moh.gov.cn/mohbgt/s10788/201005/47529.shtml (accessed May 19, 2010).
8 Imwong M, Sudimack D, Pukrittayakamee S, Osorio L, Carlton JM, Day NP, White NJ, Anderson TJ. Microsatellite variation, repeat array length, and population history of Plasmodium vivax. Mol Biol Evol 2006; 23: 1016-1018.   DOI
9 Borre MB, Dziegiel M, Hogh B, Petersen E, Rieneck K, Riley E, Meis JF, Aikawa M, Nakamura K, Harada M. Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle. Mol Biochem Parasitol 1991; 49: 119-131.   DOI
10 Kho WG, Chung JY, Sim EJ, Kim DW, Chung WC. Analysis of polymorphic regions of Plasmodium vivax Duffy binding protein of Korean isolates. Korean J Parasitol 2001; 39: 143-150.   DOI
11 Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, Ursos LM, Sidhu AB, Naude B, Deitsch KW, Su XZ, Wootton JC, Roepe PD, Wellems TE. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol Cell 2000; 6: 861-871.   DOI
12 Sidhu AB, Verdier-Pinard D, Fidock DA. Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations. Science 2002; 298: 210-213.   DOI
13 Sidhu AB, Valderramos SG, Fidock DA. pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum. Mol Microbiol 2005; 57: 913-926.   DOI
14 Sanchez CP, Rotmann A, Stein WD, Lanzer M. Polymorphisms within PfMDR1 alter the substrate specificity for anti-malarial drugs in Plasmodium falciparum. Mol Microbiol 2008; 70: 786-798.
15 Xu C, Xu XL, Huang BC. Research progress on polymorphism in the merozoite surface protein-$3{\alpha}$ gene of Plasmodium vivax. Chin J Parasitol Parasit Dis 2013; 31: 473-476 (in Chinese).
16 Tang L. Progress in malaria control in China. Chin Med J (Engl) 2000; 113: 89-92.
17 Cotter C, Sturrock HJ, Hsiang MS, Liu J, Phillips AA, Hwang J, Gueye CS, Fullman N, Gosling RD, Feachem RG. The changing epidemiology of malaria elimination: new strategies for new challenges. Lancet 2013; 382: 900-911.   DOI
18 World Health Organization. World Malaria Report, 2011. Geneva, Switzerland. World Health Organization. 2011.
19 World Health Organization. World Malaria Report, 2013. Geneva, Switzerland. World Health Organization. 2013.
20 Zhang Q, Lai S, Zheng C, Zhang H, Zhou S, Hu W, Clements AC, Zhou XN, Yang W, Hay SI, Yu H, Li Z. The epidemiology of Plasmodium vivax and Plasmodium falciparum malaria in China, 2004-2012: from intensified control to elimination. Malar J 2014; 13: 419.   DOI
21 Bu XQ, Wang YB, Zhao CL, Chen XX, Kong XL, Zhang BG. Effects of integrated malaria control measures in Shandong Province, 2010. Chin J Parasitol Parasit Dis 2012; 24: 116-118 (in Chinese).
22 Feng J, Xia ZG, Vong S, Yang WZ, Zhou SS, Xiao N. Preparedness for malaria resurgence in China: case study on imported cases in 2000-2012. Adv Parasitol 2014; 86: 231-265.
23 Tang LH. Diagnosis, Treatment and Management of Imported Malaria Cases. Shanghai, China. Shanghai Scientific and Technical Publishers. 2010, pp 25-29.
24 World Health Organization. Basic Malaria Microscopy. Part 1. Learner's Guide. 2nd ed. Geneva, Switzerland. WHO Press. 2010.
25 Ashraf S, Kao A, Hugo C, Christophel EM, Fatunmbi B, Luchavez J, Lilley K, Bell D. Developing standards for malaria microscopy: external competency assessment for malaria microscopists in the Asia-Pacific. Malar J 2012; 11: 352.   DOI
26 Liu Y, Hsiang MS, Zhou H, Wang W, Cao Y, Gosling RD, Cao J, Gao Q. Malaria in overseas labourers returning to China: an analysis of imported malaria in Jiangsu Province, 2001-2011. Malar J 2014; 13: 29.   DOI
27 Snounou G, Viriyakosol S, Zhu XP, Jarra W, Pinheiro L, do Rosario VE, Thaithong S, Brown KN. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol Biochem Parasitol 1993; 61: 315-320.   DOI
28 Johnston SP, Pieniazek NJ, Xayavong MV, Slemenda SB, Wilkins PP, da Silva AJ. PCR as a confirmatory technique for laboratory diagnosis of malaria. J Clin Microbiol 2006; 44: 1087-1089.   DOI
29 The Chinese Center for Disease Control and Prevention of the People's Republic of China. Technology Solutions for Eliminating Malaria (edition 2011). Available at: http://www.chinacdc.cn/tzgg/201109/t20110906_52137.htm (accessed September 06, 2011).
30 The Ministry of Health of the People's Republic of China. The National Malaria Control Programme (2006-2015). Available at: http://www.moh.gov.cn/mohbgt/pw10603/200804/27565.shtml (accessed February 22, 2006).
31 Feng J, Yan H, Feng XY, Zhang L, Li M, Xia ZG, Xiao N. Imported malaria in China, 2012. Emerg Infect Dis 2014; 20: 1778-1780.
32 Xia ZG, Wang RB, Wang DQ, Feng J, Zheng Q, Deng CS, Abdulla S, Guan YY, Ding W, Yao JW, Qian YJ, Bosman A, Newman RD, Ernest T, O'leary M, Xiao N. China-Africa cooperation initiatives in malaria control and elimination. Adv Parasitol 2014; 86: 319-337.
33 Makler MT, Palmer CJ, Ager AL. A review of practical techniques for the diagnosis of malaria. Ann Trop Med Parasitol 1998; 92: 419-433.   DOI
34 Moody A. Rapid diagnostic tests for malaria parasites. Clin Microbiol Rev 2002; 15: 66-78.   DOI
35 Snounou G, Viriyakosol S, Jarra W, Thaithong S, Brown KN. Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of mixed infections. Mol Biochem Parasitol 1993; 58: 283-292.   DOI
36 Ohrt C, Purnomo, Sutamihardja MA, Tang D, Kain KC. Impact of microscopy error on estimates of protective efficacy in malaria-prevention trials. J Infect Dis 2002; 186: 540-546.   DOI
37 Collins WE, Jeffery GM. Plasmodium ovale: parasite and disease. Clin Microbiol Rev 2005; 18: 570-581.   DOI
38 Coleman RE, Sattabongkot J, Promstaporm S, Maneechai N, Tippayachai B, Kengluecha A, Rachapaew N, Zollner G, Miller RS, Vaughan JA, Thimasarn K, Khuntirat B. Comparison of PCR and microscopy for the detection of asymptomatic malaria in a Plasmodium falciparum/vivax endemic area in Thailand. Malar J 2006; 5: 121.   DOI
39 Barker RH Jr, Banchongaksorn T, Courval JM, Suwonkerd W, Rimwungtragoon K, Wirth DF. A simple method to detect Plasmodium falciparum directly from blood samples using the polymerase chain reaction. Am J Trop Med Hyg 1992; 46: 416-426.   DOI