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http://dx.doi.org/10.3347/kjp.2016.54.2.201

High Toxoplasma gondii Seropositivity among Brain Tumor Patients in Korea  

Jung, Bong-Kwang (Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine)
Song, Hyemi (Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine)
Kim, Min-Jae (Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine)
Cho, Jaeeun (Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine)
Shin, Eun-Hee (Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine)
Chai, Jong-Yil (Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine)
Publication Information
Parasites, Hosts and Diseases / v.54, no.2, 2016 , pp. 201-204 More about this Journal
Abstract
Toxoplasma gondii is an intracellular protozoan that can modulate the environment of the infected host. An unfavorable environment modulated by T. gondii in the brain includes tumor microenvironment. Literature has suggested that T. gondii infection is associated with development of brain tumors. However, in Korea, epidemiological data regarding this correlation have been scarce. In this study, in order to investigate the relationship between T. gondii infection and brain tumor development, we investigated the seroprevalence of T. gondii among 93 confirmed brain tumor patients (various histological types, including meningioma and astrocytoma) in Korea using ELISA. The results revealed that T. gondii seropositivity among brain tumor patients (18.3%) was significantly (P<0.05) higher compared with that of healthy controls (8.6%). The seropositivity of brain tumor patients showed a significant age-tendency, i.e., higher in younger age group, compared with age-matched healthy controls (P<0.05). In conclusion, this study supports the close relationship between T. gondii infection and incidence of brain tumors.
Keywords
Toxoplasma gondii; seroprevalence; brain tumor; ELISA;
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1 Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin D, Forman D, Bray F. GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC cancer base no. 11 [Internet]. International Agency for Research on Cancer 2012, Lyon, France, 2013. http://globocan.iarc.fr.
2 Fisher JL, Scharwtzbaum JA, Wrensch M, Wiemels JL. Epidemiology of brain tumors. Neurol Clin 2007; 25: 867-890.   DOI
3 Pagano JS, Blaser M, Buendia MA, Damania B, Khalili K, Raab-Traub N, Roizman B. Infectious agents and cancer: criteria for a causal relation. Semin Cancer Biol 2004; 14: 453-471.   DOI
4 Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Freeman C, Galichet L, Cogliano V; WHO International Agency for Research on Cancer Monograph Working Group. A review of human carcinogens. Part B: biological agents. Lancet Oncol 2009; 10: 321-322.   DOI
5 Alibek K, Kakpenova A, Baiken Y. Role of infectious agents in the carcinogenesis of brain and head and neck cancers. Infect Agent Cancer 2013; 8: 7.   DOI
6 Correia da Costa JM, Vale N, Gouveia MJ, Botelho MC, Sripa B, Santos LL, Santos JH, Rinaldi G, Brindley PJ. Schistosome and liver fluke derived catechol-estrogens and helminth associated cancers. Front Genet 2014; 5: 444.
7 Del Brutto OH, Dolezal M, Castillo PR, Garcia HH. Neurocysticercosis and oncogenesis. Arch Med Res 2000; 31: 151-155.   DOI
8 Muehlenbachs A, Bhatnagar J, Agudelo CA, Hidron A, Eberhard ML, Mathison BA, Frace MA, Ito A, Metcalfe MG, Rollin DC, Visvesvara GS, Pham CD, Jones TL, Greer PW, Velez Hoyos A, Olson PD, Diazgranados LR, Zaki SR. Malignant transformation of Hymenolepis nana in a human host. N Engl J Med 2015; 373: 1845-1852.   DOI
9 Tenter AM, Heckeroth AR, Weiss LM. Toxoplasma gondii: from animals to humans. Int J Parasitol 2000; 30: 1217-1258.   DOI
10 Schuman LM, Choi NW, Gullen WH. Relationship of central nervous system neoplasms to Toxoplasma gondii infection. Am J Public Health Nations Health 1967; 57: 848-856.   DOI
11 Thirugnanam S, Rout N, Gnanasekar M. Possible role of Toxoplasma gondii in brain cancer through modulation of host microRNAs. Infect Agent Cancer 2013; 8: 8.   DOI
12 Vittecoq M, Elguero E, Lafferty KD, Roche B, Brodeur J, Gauthier-Clerc M, Misse D, Thomas F. Brain cancer mortality rates increase with Toxoplasma gondii seroprevalence in France. Infect Genet Evol 2012; 12: 496-498.   DOI
13 Ryan P, Hurley SF, Johnson AM, Salzberg M, Lee MW, North JB, McNeil JJ, McMichael AJ. Tumours of the brain and presence of antibodies to Toxoplasma gondii. Int J Epidemiol 1993; 22: 412-419.   DOI
14 Yazar S, Yaman O, Eser B, Altuntas F, Kurnaz F, Sahin I. Investigation of anti-Toxoplasma gondii antibodies in patients with neoplasia. J Med Microbiol 2004; 53: 1183-1186.   DOI
15 Cong W, Liu GH, Meng QF, Dong W, Qin SY, Zhang FK, Zhang XY, Wang XY, Qian AD, Zhu XQ. Toxoplasma gondii infection in cancer patients: prevalence, risk factors, genotypes and association with clinical diagnosis. Cancer Lett 2015; 359: 307-313.   DOI
16 Yuan Z, Gao S, Liu Q, Xia X, Liu X, Liu B, Hu R. Toxoplasma gondii antibodies in cancer patients. Cancer Lett 2007; 254: 71-74.   DOI
17 Shin DW, Cha DY, Hua QJ, Cha GH, Lee YH. Seroprevalence of Toxoplasma gondii infection and characteristics of seropositive patients in general hospitals in Daejeon, Korea. Korean J Parasitol 2009; 47: 125-130.   DOI
18 Thomas F, Lafferty KD, Brodeur J, Elguero E, Gauthier-Clerc M, Misse D. Incidence of adult brain cancers is higher in countries where the protozoan parasite Toxoplasma gondii is common. Biol Lett 2012; 8: 101-103.   DOI
19 Lim H, Lee SE, Jung BK, Kim MK, Lee MY, Nam HW, Shin JG, Yun CH, Cho HI, Shin EH, Chai JY. Serologic survey of toxoplasmosis in Seoul and Jeju-do, and a brief review of its seroprevalence in Korea. Korean J Parasitol 2012; 50: 287-293.   DOI
20 Flegr J. Influence of latent toxoplasmosis on the phenotype of intermediate hosts. Folia Parasitol (Praha) 2010; 57: 81-87.   DOI
21 Dubey JP, Lindsay DS, Speer CA. Structures of Toxoplasma gondii tachyzoites, bradyzoites, and sporozoites and biology and development of tissue cysts. Clin Microbiol Rev 1998; 11: 267-299.
22 Molestina RE, El-Guendy N, Sinai AP. Infection with Toxoplasma gondii results in dysregulation of the host cell cycle. Cell Microbiol 2008; 10: 1153-1165.   DOI
23 Facer CA, Playfair JH. Malaria, Epstein-Barr virus, and the genesis of lymphomas. Adv Cancer Res 1989; 53: 33-72.