[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.3347/kjp.2014.52.6.695

Chronic Opisthorchis viverrini Infection and Associated Hepatobiliary Disease Is Associated with Iron Loaded M2-like Macrophages

Bility, Moses T. (Department of Microbiology and Immunology, University of North Carolina)
Sripa, Banchob (Department of Pathology, Khon Kaen University)

Publication Information

Parasites, Hosts and Diseases / v.52, no.6, 2014 , pp. 695-699 More about this Journal

Abstract

Chronic Opisthorchis viverrini-induced hepatobiliary disease is associated with significant leukocyte infiltration, including activated macrophages; however, the polarization of infiltrating macrophages remains to be fully characterized. In this study, we characterized macrophage polarization and phenotype in chronic O. viverrini-induced hepatobiliary disease in humans and hamsters using gene expression and histochemical analysis. Chronic O. viverrini infection and associated hepatobiliary diseases were associated with iron loaded M2-like macrophages in both humans and hamsters. This study provides suggestive evidence that iron loaded M2-like macrophages promote hepatobiliary disease in chronic O. viverrini infection.

Keywords

Opisthorchis viverrini; M2-like macrophage; iron; hepatobiliary fibrosis; cancer;

Citations & Related Records

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