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http://dx.doi.org/10.3347/kjp.2013.51.5.583

Alteration of Cytokine Production during Visceral Larva Migrans by Toxascaris leonina in Mice  

Kang, Shin Ae (Department of Parasitology, School of Medicine, Pusan National University, and Immunoregulatory Therapeutics Group in Brain Busan 21 Project)
Park, Mi-Kyung (Department of Parasitology, School of Medicine, Pusan National University, and Immunoregulatory Therapeutics Group in Brain Busan 21 Project)
Cho, Min Kyoung (Department of Parasitology, School of Medicine, Pusan National University, and Immunoregulatory Therapeutics Group in Brain Busan 21 Project)
Yu, Hak Sun (Department of Parasitology, School of Medicine, Pusan National University, and Immunoregulatory Therapeutics Group in Brain Busan 21 Project)
Publication Information
Parasites, Hosts and Diseases / v.51, no.5, 2013 , pp. 583-588 More about this Journal
Abstract
To determine alteration of immune responses during visceral larva migrans (VLM) caused by Toxascaris leonina at several time points, we experimentally infected mice with embryonated eggs of T. leonina and measured T-helper (Th) cell-related serial cytokine production after infection. At day 5 post infection (PI), most larvae were detected from the lungs, spleen, intestine, and muscle. Expression of thymic stromal lymphopoietin (TSLP) and CCL11 (eotaxin) showed a significant increase in most infected organs, except the intestine. However, expression of the CXCL1 (Gro-${\alpha}$) gene was most highly enhanced in the intestine at day 14 PI. Th1-related cytokine secretion of splenocytes showed increases at day 28 PI, and the level showed a decrease at day 42 PI. Th2-related cytokine secretion of splenocytes also showed an increase after infection; in particular, IL-5 level showed a significant increase at day 14 PI, and the level showed a decrease at day 28 PI. However, levels of Th17-related cytokines, IL-6 and IL-17A, showed gradual increases until day 42 PI. In conclusion, Th1, Th2, and Th17-related cytokine production might be important in immune responses against T. leonina VLM in experimental mice.
Keywords
Toxascaris leonina; visceral larva migrans (VLM); Th1; Th2; Th17; cytokine;
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