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http://dx.doi.org/10.3347/kjp.2008.46.4.293

Malondialdehyde, Glutathione, and Nitric Oxide Levels in Toxoplasma gondii Seropositive Patients  

Karaman, Ulku (Inonu University School of Medicine, Department of Parasitology)
Celik, Tuncay (Inonu University School of Medicine, Department of Parasitology)
Kiran, Tugba Raika (Inonu University School of Medicine, Department of Biochemistry and Clinical Biochemistry)
Colak, Cemil (Firat University Department of Statistics)
Daldal, Nilgun Ulfet (Inonu University School of Medicine, Department of Parasitology)
Publication Information
Parasites, Hosts and Diseases / v.46, no.4, 2008 , pp. 293-295 More about this Journal
Abstract
The aim of this study was to investigate the difference in the serum malondialdehyde (MDA), glutathione (GSH), and nitric oxide (NO) levels between normal and T. gondii-infected patients. To this end, MDA, GSH, and NO levels in the sera of 37 seropositive patients and 40 participants in the control group were evaluated. In Toxoplasma ELISA, IgG results of the patient group were $1,013.0{\pm}543.8$ in optical density (mean ${\pm}$ SD). A statistically significant difference was found between patients and the control group in terms of MDA, GSH, and NO levels. A decrease in GSH activity was detected, while MDA and NO levels increased significantly. Consequently, it is suggested that the use of antioxidant vitamins in addition to a parasite treatment shall prove useful. The high infection vs control ratio of MDA and NO levels probably suggests the occurrence as a mechanism of tissue damage in cases of chronic toxoplasmosis. Moreover, it is recommended that the patient levels of MDA, GSH, and NO should be evaluated in toxoplasmosis.
Keywords
Toxoplasma gondii; malondialdehyde; glutathione; nitric oxide;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 6  (Related Records In Web of Science)
Times Cited By SCOPUS : 6
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1 Koltas IS, Yucebilgic G, Bilgin R, Parsak CK, Sakman G. Serum malondialdehyde level in patients with cystic echinococcosis. Saudi Med J 2006; 27: 1703-1705   PUBMED
2 Gensert JM, Ratan RR. The metabolic coupling of arginine metabolism to nitric oxide generation by astrocytes. Antioxid Redox Signal 2006; 8: 5-6
3 Aladag A, Turkoz Y, Ozerol IB. Nitric oxide and its neurophysiopathological effects. Turk J Med Sci 2000; 20: 107-111
4 Ding M, Kwok LY, Schluter D, Clayton C, Soldati D. The antioxidant systems in Toxoplasma gondii and the role of cytosolic catalase in defence against oxidative injury. Mol Microbiol 2004; 51: 47-61   DOI   ScienceOn
5 Mercan U. The importance of free radicals in toxicology. YYU J Vet Faculty 2004; 15: 91-96
6 Kang KM, Lee GS, Lee JH, Choi IW, Shin DW, Lee YH. Effects of INOS inhibitor on IFN-${\gamma}$production and apoptosis of splenocytes in genetically different strains of mice infected with Toxoplasma gondii. Korean J Parasitol 2004; 42: 175-183   DOI   ScienceOn
7 Akkus I. Effects of free radicals and pathophysiological. Konya, Turkey. Mimoza Publisher: 32 ISBN 975-543-038-5. 1995, p 1-76
8 Yazar S, Kilic E, Saraymen R, Ozbilge H. Serum malondialdehyde levels in patients infected with plasmodium. West Indian Med 2004; 53: 147-149
9 Yazar S, Kilic E, Saraymen R, Sahin I. Serum malondialdehyde leves in Toxoplasma seropositive patients. Ann Saudi Med 2003; 23: 413-415   DOI   PUBMED
10 Rozenfeld C, Martinez R, Figueiredo RT, Bozza MT, Lima FR, Pires AL, Silva PM, Bonomo A, Lannes-Vieira J, De Souza W, Moura-Neto V. Soluble factors released by Toxoplasma gondiiinfected astrocytes down-modulate nitric oxide production by gamma interferon-activated microglia and prevent neuronal degeneration. Infect Immun 2003; 71: 2047-2057   DOI
11 Nishikawa Y, Kawasa O, Vielemeyer O, Suzuki H, Joiner KA, Xuar X, Nagasawa H. Toxoplasma gondii infection induces apoptosis in noninfected macrophages: role of nitric oxide and other soluble factors. Parasite Immunol 2007; 29: 375-385   DOI   ScienceOn
12 Atambay M, Karabulut AB, Aycan OM, Kilic E, Yazar S, Saraymen R, Karaman U, Daldal N. Dust-mites: effect on lipid peroxidation. Natl Med J India 2006; 19: 75-77   PUBMED
13 Uchiyama M, Mihara M. Determination of malondialdehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978; 34: 271-8
14 Fairbanks V, Klee GG. Biochemical aspects of hematology. In Tietz NW ed, Textbook of Clinical Chemistry. Philadelphia, USA. W.B. Saunders Co. 1986, p 1532-1534
15 Deorari AK, Broor S, Maitreyi RS, Agarwal D, Kumar H, Paul VK, Singh M. Incidence, clinical spectrum and outcome of intrauterine infections in neonates. J Trop Pediatr 2000; 46: 155-159   DOI   ScienceOn
16 Daubener W, Posdziech V, Hadding U, Mackenzie CR. Inducuble anti-parasitic effector mechanisms in human uropethelial cells: tryptophan degradation vs. NO production. Med Microbiol Immunol 1999; 187: 143-147   DOI