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http://dx.doi.org/10.3347/kjp.2008.46.4.261

A Case of Fatal Strongyloidiasis in a Patient with Chronic Lymphocytic Leukemia and Molecular Characterization of the Isolate  

Kia, Eshrat Beigom (School of Public Health, Medical Sciences/University of Tehran)
Rahimi, Hamid Reza (AI-Zahra Medical Centre, Isfahan University of Medical Sciences, Isfahan)
Mirhendi, Hossein (School of Public Health, Medical Sciences/University of Tehran)
Nilforoushan, Mohammad Reza (School of Public Health, Medical Sciences/University of Tehran)
Talebi, Ardeshir (AI-Zahra Medical Centre, Isfahan University of Medical Sciences)
Zahabiun, Farzaneh (School of Public Health, Medical Sciences/University of Tehran)
Kazemzadeh, Hamid (AI-Zahra Medical Centre, Isfahan University of Medical Sciences)
Meamar, Ahmad Reza (School of Medicine, Iran University of Medical Sciences)
Publication Information
Parasites, Hosts and Diseases / v.46, no.4, 2008 , pp. 261-263 More about this Journal
Abstract
Strongyloides stercoralis is a human intestinal parasite which may lead to complicated strongyloidiasis in immunocompromised. Here, a case of complicated strongyloidiasis in a patient with chronic lymphocytic leukemia is reported. Presence of numerous S. stercoralis larvae in feces and sputum confirmed the diagnosis of hyperinfection syndrome in this patient. Following recovery of filariform larvae from agar plate culture of the stool, the isolate was characterized for the ITS1 region of ribosomal DNA gene by nested-PCR and sequencing. Albendazole therapy did not have cure effects; and just at the beginning of taking ivermectin, the patient died. The most important clue to prevent such fatal consequences is early diagnosis and proper treatment.
Keywords
Strongyloides stercoralis; hyperinfection; chronic lymphocytic leukemia; ITS1; ribosomal DNA;
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