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Changing Patterns of Serum and Bile Antibodies in Re-infected Rats with Clonorchis sinensis  

Zhang, Hong-Man (Department of Parasitology and Tropical Medicine, Institute of Endemic Diseases, Seoul National University College of Medicine)
Chung, Byung-Suk (Department of Parasitology and Tropical Medicine, Institute of Endemic Diseases, Seoul National University College of Medicine)
Li, Shun-Yu (Department of Parasitology and Tropical Medicine, Institute of Endemic Diseases, Seoul National University College of Medicine)
Choi, Min-Ho (Department of Parasitology and Tropical Medicine, Institute of Endemic Diseases, Seoul National University College of Medicine)
Hong, Sung-Tae (Department of Parasitology and Tropical Medicine, Institute of Endemic Diseases, Seoul National University College of Medicine)
Publication Information
Parasites, Hosts and Diseases / v.46, no.1, 2008 , pp. 17-22 More about this Journal
Abstract
Rats develop strong resistance to re-infection and super-infection by Clonorchis sinensis. The present study investigated the antibodies present in the sera and bile juice of rats that were primary infected and re-infected with C. sinensis. The serum level of specific IgG antibodies, which were elevated 2 wk of the primary infection, peaked at 4 wk and subsequently remained unchanged even during re-infection. The total IgE level in serum increased slowly from 388 ng / ml to 3,426 ng / ml beginning 2 wk after the primary infection, and remained high up to 8 wk but dropped to a normal level (259 ng / ml) after treatment. In resistant re-infected rats, the serum IgE level increased rapidly and peaked within 1 wk, whereas no increase was observed in immunosuppressed rats. The serum level of specific IgA antibodies was elevated beginning 1 wk after infection, and decreased 4 wk after treatment. The total bile IgA level unchanged during the primary infection but increased in treated and re-infected rats. The elevated levels of serum IgE and bile IgA indicate that these immunoglobulins may be correlated with the development of resistance to re-infection by C. sinensis in rats.
Keywords
Clonorchis sinensis; Serum; Bile juice; IgA; IgE; Rat; Re-infection;
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Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By Web Of Science : 2  (Related Records In Web of Science)
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