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http://dx.doi.org/10.1016/j.jgr.2020.06.001

Effect of Korean Red Ginseng through comparative analysis of cardiac gene expression in db/db mice

Jang, Young-Jin (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University)
Aravinthan, Adithan (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University)
Hossain, Mohammad Amjad (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University)
Kopalli, Spandana Rajendra (Department of Integrative Bioscience and Biotechnology, Sejong University)
Kim, Bumseok (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University)
Kim, Nam Soo (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University)
Kang, Chang-Won (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University)
Kim, Jong-Hoon (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University)

Publication Information

Journal of Ginseng Research / v.45, no.3, 2021 , pp. 450-455 More about this Journal

Abstract

Korean Red Ginseng (KRG) is an herbal oriental medicine known to alleviate cardiovascular dysfunction. To analysis the expression of diabetic cardiac complication-associated genes in db/db mice, we studied the cardiac gene expression following KRG treatment. In result, a total of 585 genes were found to be changed in db/db mice. Among the changed expression, 245 genes were found to 2-fold upregulated, and 340 genes were 2-fold downregulated. In addition, the changed gene expressions were ameliorated by KRG. In conclusion, KRG may be possible to normalize cardiac gene expressions in db/db mice.

Keywords

Panax ginseng; Diabetes mellitus; Diabetic cardiac complication; Microarray; Gene profiling;

Citations & Related Records

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