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http://dx.doi.org/10.1016/j.jgr.2020.09.002

Ginseng polysaccharides: A potential neuroprotective agent  

Wang, Na (School of Pharmacy, Shandong University of Traditional Chinese Medicine)
Wang, Xianlei (National Oceanographic Center)
He, Mengjiao (School of Pharmacy, Shandong University of Traditional Chinese Medicine)
Zheng, Wenxiu (School of Pharmacy, Shandong University of Traditional Chinese Medicine)
Qi, Dongmei (Experimental center, Shandong University of Traditional Chinese Medicine)
Zhang, Yongqing (School of Pharmacy, Shandong University of Traditional Chinese Medicine)
Han, Chun-chao (School of Pharmacy, Shandong University of Traditional Chinese Medicine)
Publication Information
Journal of Ginseng Research / v.45, no.2, 2021 , pp. 211-217 More about this Journal
Abstract
The treatments of nervous system diseases (NSDs) have long been difficult issues for researchers because of their complexity of pathogenesis. With the advent of aging society, searching for effective treatments of NSDs has become a hot topic. Ginseng polysaccharides (GP), as the main biologically active substance in ginseng, has various biological properties in immune-regulation, anti-oxidant, anti-inflammation and etc. Considering the association between the effects of GP and the pathogenesis of neurological disorders, many related experiments have been conducted in recent years. In this paper, we reviewed previous studies about the effects and mechanisms of GP on diseases related to nervous system. We found GP play an ameliorative role on NSDs through the regulation of immune system, inflammatory response, oxidative damage and signaling pathway. Structure-activity relationship was also discussed and summarized. In addition, we provided new insights into GP as promising neuroprotective agent for its further development and utilization.
Keywords
Ginseng; Molecular mechanism; Nervous system; Polysaccharides;
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1 Coyle JT, Duman RS. Finding the intracellular signaling pathways affected by mood disorder treatments. Neuron 2003;38(2):157-60.   DOI
2 Wiklund IK, Mattsson LA, Lindgren R, Limoni C. Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. Swedish Alternative Medicine Group. Int J Clin Pharmacol Res 1999;19(3):89-99.
3 McEwen BS, Nasca C, Gray JD. Stress effects on neuronal structure: Hippocampus, amygdala, and prefrontal cortex. Neuropsychopharmacology 2016;41(1):3-23.   DOI
4 Muneer A. Wnt and GSK3 signaling pathways in bipolar disorder: clinical and therapeutic implications. Clin Psychopharmacol Neurosci 2017;15(2):100-14.   DOI
5 Zhou SS, Xu J, Zhu H, Wu J, Xu JD, Yan R, Li XY, Liu HH, Duan SM, Wang Z, et al. Gut microbiota-involved mechanisms in enhancing systemic exposure of ginsenosides by coexisting polysaccharides in ginseng decoction. Sci Rep 2016;6:22474.   DOI
6 Van Kaer L, Postoak JL, Wang C, Yang G, Wu L. Innate, innate-like and adaptive lymphocytes in the pathogenesis of MS and EAE. Cell Mol Immunol 2019;16(6):531-9.   DOI
7 Halliwell B. Free radicals and antioxidants: a personal view. Nutr Rev 1994;52(8 Pt 1):253-65.   DOI
8 Cryan JF, Page ME, Lucki I. Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment. Psychopharmacology (Berl) 2005;182(3):335-44.   DOI
9 Kessler RC, Bromet EJ. The epidemiology of depression across cultures. Annu Rev Public Health 2013;34:119-38.   DOI
10 Hwang I, Ahn G, Park E, Ha D, Song JY, Jee Y. An acidic polysaccharide of Panax ginseng ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells. Immunol Lett 2011;138(2):169-78.   DOI
11 Li B, Zhang N, Feng Q, Li H, Wang D, Ma L, Liu S, Chen C, Wu W, Jiao L. The core structure characterization and of ginseng neutral polysaccharide with the immune-enhancing activity. Int J Biol Macromol 2019;123:713-22.   DOI
12 Sun Y. Structure and biological activities of the polysaccharides from the leaves, roots and fruits of Panax ginseng C.A. Meyer: an overview. Carbohydr Polym 2011;85(3):490-9.   DOI
13 Cassilhas RC, Tufik S, de Mello MT. Physical exercise, neuroplasticity, spatial learning and memory. Cell Mol Life Sci 2016;73(5):975-83.   DOI
14 Ferreira SS, Passos CP, Madureira P, Vilanova M, Coimbra MA. Structure-function relationships of immunostimulatory polysaccharides: a review [published correction appears in Carbohydr Polym. 2016 Aug 20;147:557-558]. Carbohydr Polym 2015;132:378-96.   DOI
15 Arzani M, Jahromi SR, Ghorbani Z, Vahabizad F, Martelletti P, Ghaemi A, Sacco S, Togha M. Gut-brain Axis and migraine headache: a comprehensive review. J Headache Pain 2020;21(1):15.   DOI
16 Jia D, Deng Y, Gao J, Liu X, Chu J, Shu Y. Neuroprotective effect of Panax notoginseng plysaccharides against focal cerebral ischemia reperfusion injury in rats. Int J Biol Macromol 2014;63:177-80.   DOI
17 Sun L, Wu D, Ning X, Yang G, Lin ZH, Tian MH, Zhou YF. a-Amylase-assisted extraction of polysaccharides from Panax ginseng. Int J Biol Macromol 2015;75:152-7.   DOI
18 Nery TGM, Silva EM, Tavares R, Passetti F. The challenge to search for new nervous system disease biomarker candidates: the opportunity to use the proteogenomics approach. J Mol Neurosci 2019;67(1):150-64.   DOI
19 Magistretti PJ, Allaman I. A cellular perspective on brain energy metabolism and functional imaging. Neuron 2015;86(4):883-901.   DOI
20 Qi YL, Li SS, Qu D, Chen LX, Gong RZ, Gao K, Sun YS. Effects of ginseng neutral polysaccharide on gut microbiota in antibiotic-associated diarrhea mice. Zhongguo Zhong Yao Za Zhi 2019;44(4):811-8.
21 Wang L, Yu X, Yang X, Li Y, Yao Y, Lui EM, Ren G. Structural and anti-inflammatory characterization of a novel neutral polysaccharide from North American ginseng (Panax quinquefolius). Int J Biol Macromol 2015;74:12-7.   DOI
22 Zhang X, Yu L, Bi H, Li X, Ni W, Han H. Total fractionation and characterization of the water-soluble polysaccharides isolated from panax ginseng C. A. Meyer. Carbohydr Polym 2009;77(3):544-52.   DOI
23 Tomoda M, Takeda K, Shimizu N, Gonda R, Ohara N, Takada K, Hirabayashi K. Characterization of two acidic polysaccharides having immunological activities from the root of Panax ginseng. Biol Pharm Bull 1993;16(1):22-5.   DOI
24 Huang J, Brumell JH. NADPH oxidases contribute to autophagy regulation. Autophagy 2009;5(6):887-9.   DOI
25 Patel M. Targeting oxidative stress in central nervous system disorders. Trends Pharmacol Sci 2016;37(9):768-78.   DOI
26 Hwang SH, Shin TJ, Choi SH, Cho HJ, Lee BH, Pyo MK. Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates g protein-coupled lysophosphatidic acid receptors with high affinity. Molecules & Cells 2012;33(2):151-62.   DOI
27 Cragnolini AB, Lampitella G, Virtuoso A, Viscovo I, Panetsos F, Papa M, Cirillo G. Regional brain susceptibility to neurodegeneration: what is the role of glial cells? Neural Regen Res 2020;15(5):838-42.   DOI
28 Franco R, Fernandez-Suarez D. Alternatively activated microglia and macrophages in the central nervous system. Prog Neurobiol 2015;131:65-86.   DOI
29 Rokot NT, Kairupan TS, Cheng KC, Runtuwene J, Kapantow NH, Amitani M, Morinaga A, Amitani H, Asakawa A, Inui A. A role of ginseng and its constituents in the treatment of central nervous system disorders. Evid Based Complement Alternat Med 2016;2016:2614742.
30 Johnston MV. Plasticity in the developing brain: implications for rehabilitation. Dev Disabil Res Rev 2009;15(2):94-101.   DOI
31 Gulyaeva NV. Molecular mechanisms of neuroplasticity: an expanding universe. Biochemistry (Mosc) 2017;82(3):237-42.   DOI
32 Jin Y, Peng J, Wang X, Zhang D, Wang T. Ameliorative effect of ginsenoside Rg1 on lipopolysaccharide-induced cognitive impairment: role of cholinergic system. Neurochem Res 2017;42(5):1299-307.   DOI
33 Shaw CA, Lanius RA, van den Doel K. The origin of synaptic neuroplasticity: crucial molecules or a dynamical cascade? Brain Res Brain Res Rev 1994;19(3):241-63.   DOI
34 Lyubimov II, Borzenkov VM, Chepurnova NE, Chepurnov SA. Effect of a polysaccharide fraction of ginseng root on learning and memory in rats (using an active escape response as an example). Neurosci Behav Physiol 1997;27(5):555-8.   DOI
35 Porsolt RD, Bertin A, Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 1977;229(2):327-36.
36 Dias V, Junn E, Mouradian MM. The role of oxidative stress in Parkinson's disease. J Parkinsons Dis 2013;3(4):461-91.   DOI
37 Zheng Y, Yang G, Zhao Z, Guo T, Shi H, Zhou Y. Structural analysis of ginseng polysaccharides extracted by edta solution. Rsc Advances 2015;6(4):2724-30.
38 Heo JH, Lee ST, Oh MJ, Park HJ, Shim JY, Chu K, Kim M. Improvement of cognitive deficit in Alzheimer's disease patients by long term treatment with Korean red ginseng. J Ginseng Res 2011;35(4):457-61.   DOI
39 Lee MJ, Chang BJ, Oh S, Nah SY, Cho IH. Korean Red Ginseng mitigates spinal demyelination in a model of acute multiple sclerosis by downregulating p38 mitogen-activated protein kinase and nuclear factor-kB signaling pathways. J Ginseng Res 2018;42:436-46.   DOI
40 Takashima A. GSK-3β and memory formation. Front Mol Neurosci 2012;5:47.   DOI
41 Wang J, Flaisher-Grinberg S, Li S, Liu H, Sun L, Zhou Y, Einat H. Antidepressant-like effects of the active acidic polysaccharide portion of ginseng in mice. J Ethnopharmacol 2010;132(1):65-9.   DOI
42 Salim S. Oxidative stress and the central nervous system. J Pharmacol Exp Ther 2017;360(1):201-5.   DOI
43 Chen F, Huang G. Antioxidant activity of polysaccharides from different sources of ginseng. Int J Biol Macromol 2019;125:906-8.   DOI
44 Yang X, Wang R, Zhang S, Zhu W, Tang J, Liu J, Chen P, Zhang D, Ye W, Zheng Y. Polysaccharides from Panax japonicus C.A. Meyer and their antioxidant activities. Carbohydr Polym 2014;101:386-91.   DOI
45 Byeon SE, Lee J, Kim JH, Yang WS, Kwak YS, Kim SY, Choung ES, Rhee MH, Cho JY. Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean red ginseng. Mediators Inflamm 2012;2012:732860.
46 Agrawal A, Dillon S, Denning TL, Pulendran B. ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis. J Immunol 2006;176(10):5788-96.   DOI
47 Wang J, Li Y, Luo P, Chen Y, Xi Q, Wu H, Zhao W, Shu G, Wang S, Gao P. Oral supplementation with ginseng polysaccharide promotes food intake in mice. Brain Behav 2019;9(9):e01340.
48 Lanfumey L, Hamon M. Approche neurobiologique de la depression: nouvelles donnees [Neurobiology of depression: new data]. Therapie 2005;60(5):431-40.   DOI
49 Xu T, Shen X, Yu H, Sun L, Lin W, Zhang C. Water-soluble ginseng oligosaccharides protect against scopolamine-induced cognitive impairment by functioning as an antineuroinflammatory agent. J Ginseng Res 2016;40(3):211-9.   DOI
50 Xiong X, Huang G, Huang H. The antioxidant activities of phosphorylated polysaccharide from native ginseng. Int J Biol Macromol 2019;126:842-5.   DOI
51 Garg N, Smith TW. An update on immunopathogenesis, diagnosis, and treatment of multiple sclerosis. Brain Behav 2015;5(9):e00362.
52 Ghorbani MM, Farazmandfar T, Nasirikenari M, Abediankenari S, Meamarian A, Shahbazi M. Evaluation of IL-17 serum level, brain inflammation and demyelination in experimental autoimmune encephalomyelitis C57BL/6 mice model with different doses of myelin oligodendrocyte glycoprotein. Iran J Allergy Asthma Immunol 2019;18(3):300-9.
53 Buc M. Role of regulatory T cells in pathogenesis and biological therapy of multiple sclerosis. Mediators Inflamm 2013;2013:963748.   DOI
54 Lublin FD, Reingold SC, Cohen JA, Cutter GR, Sorensen PS, Thompson AJ, Wolinsky JS, Balcer LJ, Banwell B, Barkhof F, et al. Defining the clinical course of multiple sclerosis: the 2013 revisions. Neurology 2014;83(3):278-86.   DOI
55 Ahn JY, Song JY, Yun YS, Jeong G, Choi IS. Protection of Staphylococcus aureusinfected septic mice by suppression of early acute inflammation and enhanced antimicrobial activity by ginsan. FEMS Immunol Med Microbiol 2006;46(2):187-97.   DOI
56 Rincon M, Flavell RA, Davis RA. The JNK and P38 MAP kinase signaling pathways in T cell-mediated immune responses. Free Radic Biol Med 2000;28(9):1328-37.   DOI
57 Ivanovska N, Saso L, Dimitrov P. Kinase inhibitors with redox and anti-inflammatory activities. Curr Top Med Chem 2015;15(9):872-85.   DOI
58 Zhang X, Li S, Sun L, Ji L, Zhu J, Fan Y, Tai G, Zhou Y. Further analysis of the structure and immunological activity of an RG-I type pectin from Panax ginseng. Carbohydr Polym 2012;89(2):519-25.   DOI
59 Chu F, Shi M, Zheng C, Shen D, Zhu J, Zheng X, Cui L. The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis. J Neuroimmunol 2018;318:1-7.   DOI
60 Hatch MN, Schaumburg CS, Lane TE, Keirstead HS. Endogenous remyelination is induced by transplant rejection in a viral model of multiple sclerosis. J Neuroimmunol 2009;212(1e2):74-81.   DOI
61 Buigues C, Padilla-Sanchez C, Garrido JF, Navarro-Martinez R, Ruiz-Ros V, Cauli O. The relationship between depression and frailty syndrome: a systematic review. Aging Ment Health 2015;19(9):762-72.   DOI
62 Kasper LH, Shoemaker J. Multiple sclerosis immunology: the healthy immune system vs the MS immune system. Neurology 2010;74(Suppl 1):S2-8.   DOI
63 Bing SJ, Ha D, Hwang I, Park E, Ahn G, Song JY, Jee Y. Protective effects on central nervous system by acidic polysaccharide of panax ginseng in relapse-remitting experimental autoimmune encephalomyelitis-induced SJL/J mice. Am J Chin Med 2016;44(6):1099-110.   DOI
64 Kim MH, Byon YY, Ko EJ, Song JY, Yun YS, Shin T, Joo HG. Immunomodulatory activity of ginsan, a polysaccharide of panax ginseng, on dendritic cells. Korean J Physiol Pharmacol 2009;13(3):169-73.   DOI
65 Xing X, Cui SW, Nie S, Phillips GO, Douglas Goff H, Wang Q. A review of isolation process, structural characteristics, and bioactivities of water-soluble polysaccharides from Dendrobium plants. Bioactive Carbohydrates & Dietary Fibre. 2013;1(2):131-47.   DOI
66 Bramini M, Ye D, Hallerbach A, Nic Raghnaill M, Salvati A, Aberg C, Dawson KA. Imaging approach to mechanistic study of nanoparticle interactions with the blood-brain barrier. ACS Nano 2014;8(5):4304-12.   DOI
67 Engelhardt B, Liebner S. Novel insights into the development and maintenance of the blood-brain barrier. Cell Tissue Res 2014;355(3):687-99.   DOI
68 Deli MA, Veszelka S, Csiszar B, Toth A, Kittel A, Csete M, Sipos A, Szalai A, Fulop L, Penke B. Protection of the blood-brain barrier by pentosan against amyloid-b-induced toxicity. J Alzheimers Dis 2010;22(3):777-94.   DOI
69 Zhu W, Ma S, Qu R, Kang D. Antidepressant-like effect of saponins extracted from Chaihu-jia-longgu-muli-tang and its possible mechanism. Life Sci 2006;79(8):749-56.   DOI
70 Penninx BW. Depression and cardiovascular disease: epidemiological evidence on their linking mechanisms. Neurosci Biobehav Rev 2017;74(Pt B):277-86.   DOI
71 Zhang E, Liao P. Brain-derived neurotrophic factor and post-stroke depression. J Neurosci Res 2020;98(3):537-48.   DOI
72 Patel A. Review: the role of inflammation in depression. Psychiatr Danub 2013;25(Suppl 2):S216-23.
73 Song YR, Sung SK, Jang M, Lim TG, Cho CW, Han CJ, Hong HD. Enzyme-assisted extraction, chemical characteristics, and immunostimulatory activity of polysaccharides from Korean ginseng (Panax ginseng Meyer). Int J Biol Macromol 2018;116:1089-97.   DOI
74 Ji L, Jie Z, Ying X, Yue Q, Zhou Y, Sun L. Structural characterization of alkali-soluble polysaccharides from Panax ginseng C. A. Meyer. R Soc Open Sci 2018;5(3):171644.   DOI
75 Hossain MJ, Morandi E, Tanasescu R, Frakich N, Caldano M, Onion D, Faraj TA, Erridge C, Gran B. The soluble form of toll-like receptor 2 is elevated in serum of multiple sclerosis patients: a novel potential disease biomarker. Front Immunol 2018;9:457.   DOI
76 Shen H, Gao XJ, Li T, Jing WH, Han BL, Jia YM, Hu N, Yan ZX, Li SL, Yan R. Ginseng polysaccharides enhanced ginsenoside Rb1 and microbial metabolites exposure through enhancing intestinal absorption and affecting gut microbial metabolism. J Ethnopharmacol 2018;216:47-56.   DOI