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http://dx.doi.org/10.1016/j.jgr.2019.08.004

Effects of red ginseng on the elastic properties of human skin  

Park, Moon Young (Department of Biomedical Engineering, College of Medicine, Kyung Hee University)
Han, Se Jik (Department of Biomedical Engineering, College of Medicine, Kyung Hee University)
Moon, Donggerami (Department of Biomedical Engineering, College of Medicine, Kyung Hee University)
Kwon, Sangwoo (Department of Biomedical Engineering, College of Medicine, Kyung Hee University)
Lee, Jin-Woo (Medical Science Research Institute, Kyung Hee University Medical Center)
Kim, Kyung Sook (Department of Biomedical Engineering, College of Medicine, Kyung Hee University)
Publication Information
Journal of Ginseng Research / v.44, no.5, 2020 , pp. 738-746 More about this Journal
Abstract
Background: Red ginseng contains components, including microelements, vitamins, essential oils, and fatty acids, that can be used in skincare to delay the aging process. We investigated the effects of red ginseng treatment on skin elasticity by assessing cellular stiffness and measuring collagen protein synthesis. Methods: Human dermal fibroblasts were treated with red ginseng, and the resulting changes in stiffness were investigated using atomic force microscopy. Cytoskeletal changes and mRNA expression of biomarkers of aging, including that of procollagens I and VII, elastin, and fibrillin-1, were investigated. Collagen in a human skin equivalent treated with red ginseng was visualized via hematoxylin and eosin staining, scanning electron microscopy, and atomic force microscopy. Results and conclusion: The stiffness of fibroblasts was significantly reduced by treatment with red ginseng concentrations of ≥ 0.8 mg/mL. The ratio of F-actin to G-actin decreased after treatment, which corresponded to a change in fibroblast stiffness. The storage modulus (G') and loss modulus (G'') of the skin equivalent were both lowered by red ginseng treatment. This result indicates that the viscoelasticity of the skin equivalent can be restored by red ginseng treatment.
Keywords
Atomic force microscopy; Cellular stiffness; Collagen; Red ginseng; Skin elasticity;
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Times Cited By KSCI : 4  (Citation Analysis)
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