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http://dx.doi.org/10.1016/j.jgr.2019.04.004

Metabolomic understanding of intrinsic physiology in Panax ginseng during whole growing seasons  

Lee, Hyo-Jung (Division of Food and Nutrition, Chonnam National University)
Jeong, Jaesik (Department of Statistics, Chonnam National University)
Alves, Alexessander Couto (Department of Epidemiology and Biostatistics, Imperial College London)
Han, Sung-Tai (R&D Headquarters, Korea Ginseng Corporation)
In, Gyo (R&D Headquarters, Korea Ginseng Corporation)
Kim, Eun-Hee (Protein Structure Group, Korea Basic Science Institute)
Jeong, Woo-Sik (Department of Food & Life Science, College of Biomedical Science & Engineering, Inje University)
Hong, Young-Shick (Division of Food and Nutrition, Chonnam National University)
Publication Information
Journal of Ginseng Research / v.43, no.4, 2019 , pp. 654-665 More about this Journal
Abstract
Background: Panax ginseng Meyer has widely been used as a traditional herbal medicine because of its diverse health benefits. Amounts of ginseng compounds, mainly ginsenosides, vary according to seasons, varieties, geographical regions, and age of ginseng plants. However, no study has comprehensively determined perturbations of various metabolites in ginseng plants including roots and leaves as they grow. Methods: Nuclear magnetic resonance ($^1H$ NMR)-based metabolomics was applied to better understand the metabolic physiology of ginseng plants and their association with climate through global profiling of ginseng metabolites in roots and leaves during whole growing periods. Results: The results revealed that all metabolites including carbohydrates, amino acids, organic acids, and ginsenosides in ginseng roots and leaves were clearly dependent on growing seasons from March to October. In particular, ginsenosides, arginine, sterols, fatty acids, and uracil diphosphate glucose-sugars were markedly synthesized from March until May, together with accelerated sucrose catabolism, possibly associated with climatic changes such as sun exposure time and rainfall. Conclusion: This study highlights the intrinsic metabolic characteristics of ginseng plants and their associations with climate changes during their growth. It provides important information not only for better understanding of the metabolic phenotype of ginseng but also for quality improvement of ginseng through modification of cultivation.
Keywords
Metabolic physiology; Metabolomics; NMR; Panax ginseng;
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