Ginseng extracts modulate mitochondrial bioenergetics of live cardiomyoblasts: a functional comparison of different extraction solvents |
Huang, Yun
(HKUST Shenzhen Research Institute)
Kwan, Kenneth Kin Leung (Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology) Leung, Ka Wing (HKUST Shenzhen Research Institute) Yao, Ping (Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology) Wang, Huaiyou (HKUST Shenzhen Research Institute) Dong, Tina Tingxia (HKUST Shenzhen Research Institute) Tsim, Karl Wah Keung (HKUST Shenzhen Research Institute) |
1 |
Mu QQ, Fang X, Li XK, Zhao DD, Mo FF, Jiang GJ, Yu N, Zhang Y, Guo YB, Fu M, et al. Ginsenoside Rb1 promotes browning through regulation of |
2 | Lin SH, Wu XT, Tao LC, Bei YH, Zhang HF, Zhou YL, Shen ST, Xiao JJ, Li XL. The metabolic effects of traditional Chinese medication Qiliqiangxin on H9C2 cardiomyocytes. Cell Physiol Biochem 2015;37:2246-56. DOI |
3 | Takanashi K, Dan K, Kanzaki S, Hasegawa H, Watanabe K, Ogawa K. Hochuekkito, a Japanese herbal medicine, restores metabolic homeostasis between mitochondrial and glycolytic pathways impaired by influenza A virus infection. Pharmacology 2017;99:240-9. DOI |
4 | Li AE, Ito H, Rovira II , Kim KS, Takeda K, Yu ZY, Ferrans VJ, Finkel T. A role for reactive oxygen species in endothelial cell anoikis. Circ Res 1999;85:304-10. DOI |
5 | Cho WCS, Yip TT, Chung WS, Lee SKW, Leung AWN, Cheng CHK, Yue KKM. Altered expression of serum protein in ginsenoside Re-treated diabetic rats detected by SELDI-TOF MS. J Ethnopharmacol 2006;108:272-9. DOI |
6 | Dhingra R, Kirshenbaum LA. Succinate dehydrogenase/complex II activity obligatorily links mitochondrial reserve respiratory capacity to cell survival in cardiac myocytes. Cell Death Dis 2015;6:1956. DOI |
7 | Nicholls DG. Spare respiratory capacity, oxidative stress and excitotoxicity. Biochem Soc Trans 2009;37:1385-8. DOI |
8 |
Brookes PS. Mitochondrial |
9 | Dott W, Mistry P, Wright J, Cain K, Herbert KE. Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicity. Redox Biol 2014;2:224-33. DOI |
10 | Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, et al. Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 2007;292:125-36. DOI |
11 | David AF, Andy N, Craig B. Advances in measuring cellular bioenergetics using extracellular flux. Drug Discovery Today 2008;13:268-74. DOI |
12 | Li HX, Han SY, Ma X, Zhang K, Wang L, Ma ZZ, Tu PF. The saponin of red ginseng protects the cardiacmyocytes against ischemic injury in vitro and in vivo. Phytomedicine 2012;19:477-83. DOI |
13 | Zhu KY, Fu Q, Xie HQ, Xu SL, Cheung AWH, Zheng KYZ, Luk WKW, Choi RCY, Lau DTW, Dong TTX, et al. Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: a chemical evaluation of different historical formulae. J Sep Sci 2010;33:3666-74. DOI |
14 | Cheng Y, Shen LH, Zhang JT. Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action. Acta Pharmacol Sin 2005;26:143-9. DOI |
15 | Park JS, Park EM, Kim DH, Jung K, Jung JS, Lee EJ, Hyun JW, Kang JL, Kim HS. Anti-inflammatory mechanism of ginseng saponins in activated microglia. J Neuroimmunol 2009;209:40-9. DOI |
16 | Keum YS, Park KK, Lee JM, Chun KS, Park JH, Lee SK, Kwon H, Surh YJ. Antioxidant and anti-tumor promoting activities of the methanol extract of heatprocessed ginseng. Cancer Lett 2000;150:41-8. DOI |
17 | Kim JH. Cardiovascular diseases and Panax ginseng: a review on molecular mechanisms and medical applications. J Ginseng Res 2012;36:16-26. DOI |
18 | Baek EB, Yoo HY, Park SJ, Chung YS, Hong EK, Kim SJ. Inhibition of arterial myogenic responses by a mixed aqueous extract of Salvia Miltiorrhiza and Panax notoginseng (PASEL) showing antihypertensive effects. Korean J Physiol Pharmacol 2009;13:287-93. DOI |
19 | Lee CH, Kim JH. A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases. J Ginseng Res 2014;38:161-6. DOI |
20 | Fung FY, Linn YC. Steroids in traditional Chinese medicine: what is the evidence? Singapore Med J 2017;58(3):115-20. DOI |
21 | Kim JY, Pham DD. Sasang constitutional medicine as a holistic tailored medicine. eCAM 2009;6:11-9. |
22 | Truong J, Mailloux RJ, Chan HM. Impact of methylmercury exposure on mitochondrial energetics in AC16 and H9C2 cardiomyocytes. Toxicol In Vitro 2015;29:953-61. DOI |
23 | Ko KM, Leon TYY, Mak DHF, Chiu PY, Du Y, Poon MKT. A characteristic pharmacological action of 'Yang-invigorating' Chinese tonifying herbs: enhancement of myocardial ATP-generation capacity. Phytomedicine 2006;13:636-42. DOI |
24 |
Papapetropoulos AA. ginseng-derived oestrogen receptor |
25 | Cheung LW, Leung KW, Wong CK, Wong RN, Wong AS. Ginsenoside-Rg1 induces angiogenesis via non-genomic crosstalk of glucocorticoid receptor and fibroblast growth factor receptor-1. Cardiovasc Res 2011;89:419-25. DOI |
26 | Zhu D, Wu L, Li CR, Wang XW, Ma YJ, Zhong ZY, Zhao HB, Cui J, Xun SF, Huang XL, et al. Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis. J Cell Biochem 2009;108:117-24. DOI |
27 | Clarke G, Ting KN, Wiart C, Fry J. High correlation of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferric reducing activity potential and total phenolics content indicates redundancy in use of all three assays to screen for antioxidant activity of extracts of plants from the Malaysian rainforest. Antioxidants 2013;2:1-10. DOI |
28 | Aravinthan A, Kim JH, Antonisamy P, Kang CW, Choi J, Kim NS, Kim JH. Ginseng total saponin attenuates myocardial injury via anti-oxidative and anti-inflammatory properties. J Gins Res 2015;39:206-12. DOI |
29 | Kim TH, Lee SM. The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart. Food Chem Toxicol 2010;48:1516-20. DOI |
30 | Shao ZH, Xie JT, Hoek TLV, Mehendale S, Aung H, Li CQ, Qin Y, Schumacker PT, Becker LB, Yuan CS. Antioxidant effects of American ginseng berry extract in cardiomyocytes exposed to acute oxidant stress. Biochimica et Biophysica Acta 2004;1670:165-71. DOI |
31 |
Kong HL, Li ZQ, Zhao YJ, Zhao SM, Zhu L, Li Tong, Fu Yao, Li HJ. Ginsenoside Rb1 protects cardiomyocytes against |
32 |
Wang Y, Li X, Wang XL, Lau W, Wang YJ, Xing Y, Zhang X, Ma XL, Gao F. Ginsenoside Rd attenuates myocardial ischemia/reperfusion injury via |
33 | Shin BK, Kwon SW, Park JH. Chemical diversity of ginseng saponins from Panax ginseng. J Ginseng Res 2015;39:287-98. DOI |
34 | Christensen LP. Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 2009;55:1-99. DOI |
35 | Nag SA, Qin JJ, Wang W, Wang MH, Wang H, Zhang R. Ginsenosides as anticancer agents: in vitro and in vivo activities, structure-activity relationships, and molecular mechanisms of action. Front Pharmacol 2012;3:1-18. DOI |
36 | Qi LW, Wang CZ, Yuan CS. Ginsenosides from American ginseng: chemical and pharmacological diversity. Phytochemistry 2011;72:689-99. DOI |
37 | Djeridane A, Yousfi M, Nadjemi B, Boutassouna D, Stocker P, Vidal N. Antioxidant activity of some algerian medicinal plants extracts containing phenolic compounds. Food Chem 2006;97:654-60. DOI |
38 | Kang KS, Kim HY, Pyo JS, Yokozawa T. Increase in the free radical scavenging activity of ginseng by heat-processing. Biol Pharm Bull 2006;29:750-4. DOI |
39 | Kang KS, Kim HY, Yamabe N, Yokozawa T. Stereospecificity in hydroxyl radical scavenging activities of four ginsenosides produced by heat processing. Bioorg Med Chem Lett 2006;16:5028-31. DOI |
40 | Lee YJ, Kim HY, Kang KS, Lee JG, Yokozawa T, Park JH. The chemical and hydroxyl radical scavenging activity changes of ginsenoside-Rb1 by heat processing. Bioorg Med Chem Lett 2008;18:4515-20. DOI |
41 | Dong GT, Chen TB, Ren XC, Zhang ZF, Huang WX, Liu L, Pa Luo, Zhou H. Rg1 prevents myocardial hypoxia/reoxygenation injury by regulating mitochondrial dynamics imbalance via modulation of glutamate dehydrogenase and mitofusin 2. Mitochondrion 2016;26:7-18. DOI |
42 | Xie JT, Shao ZH, Vanden Hoek TLV, Chang WT, Li J, Mehendale S, Wang CZ, Hsu CW, Becker LB, Yin JJ, et al. Antioxidant effects of ginsenoside Re in cardiomyocytes. Eur J Pharmacol 2006;532:201-7. DOI |
43 |
Luo JZQ, Luo LG. American Ginseng stimulates insulin production and prevents apoptosis through regulation of uncoupling protein-2 in cultured |
44 | Wang JR, Zhou H, Yi XQ, Jiang ZH, Liu L. Total ginsenosides of Radix Ginseng modulates tricarboxylic acid cycle protein expression to enhance cardiac energy metabolism in ischemic rat heart tissues. Molecules 2012;17:12746-57. DOI |
45 | Yan WH, Liu JZ. Effects of Chinese herbal monomers on oxidative phosphorylation and membrane potential in cerebral mitochondria isolated from hypoxia-exposed rats in vitro. Neural Regen Res 2012;7:2099-106. DOI |
46 | Wang Y, Liang XY, Chen YQ, Zhao XP. Screening SIRT1 activators from medicinal plants as bioactive compounds against oxidative damage in mitochondrial function. Oxid Med Cell Longev 2016;2016:4206392. DOI |
![]() |