1 |
Ando K, Heymann M-F, Stresing V, Mori K, Redini F, Heymann D. Current therapeutic strategies and novel approaches in osteosarcoma. Cancers 2013;5(2):591-616.
DOI
|
2 |
Takeda Y, Togashi H, Matsuo T, Shinzawa H, Takeda Y, Takahashi T. Growth inhibition and apoptosis of gastric cancer cell lines by Anemarrhena asphodeloides Bunge. J Gastroenterol 2001;36(2):79-90.
DOI
|
3 |
Fu YL, Yu ZY, Tang XM, Zhao Y, Yuan XL, Wang S, Ma BP, Cong YW. Pennogenin glycosides with a spirostanol structure are strong platelet agonists: structural requirement for activity and mode of platelet agonist synergism. J Thromb Haemostasis 2008;6(3):524-33.
DOI
|
4 |
Yang B-Y, Zhang J, Liu Y, Kuang H-X. Steroidal saponins from the rhizomes of Anemarrhena asphodeloides. Molecules 2016;21(8):1075.
DOI
|
5 |
King FW, Fong S, Griffin C, Shoemaker M, Staub R, Zhang Y-L, Cohen I, Shtivelman E. Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress. PLoS One 2009;4(9), e7283.
DOI
|
6 |
Sy L-K, Yan S-C, Lok C-N, Man RY, Che C-M. Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells. Cancer Res 2008;68(24):10229-37.
DOI
|
7 |
Jung O, Lee J, Lee YJ, Yun JM, Son YJ, Cho JY, Ryou C, Lee SY. Timosaponin AIII inhibits migration and invasion of A549 human non-small-cell lung cancer cells via attenuations of MMP-2 and MMP-9 by inhibitions of ERK1/2, Src/FAK and b-catenin signaling pathways. Bioorg Med Chem Lett 2016;26(16):3963-7.
DOI
|
8 |
Baguley BC. Multiple drug resistance mechanisms in cancer. Mol Biotechnol 2010;46(3):308-16.
DOI
|
9 |
KIm AD, Kang KA, Zhang R, Lim CM, Kim HS, King DH, Jeon YJ, Lee CH, Park J, Chang WY, et al. Ginseng saponin metabolite induces apoptosis in MCF-7 breast cancer cells through the modulation of AMP-activated protein kinase. Environ Toxicol Pharmacol 2010;30(2):134-40.
DOI
|
10 |
Li W, Liu Z, Zhao C, Zhai L. Binding of MMP-9-degraded fibronectin to b6 integrin promotes invasion via the FAK-Src-related Erk1/2 and PI3K/Akt/Smad-1/5/8 pathways in breast cancer. Oncol Rep 2015;34(3):1345-52.
DOI
|
11 |
Xu X, Wang Y, Chen Z, Sternlicht MD, Hidalgo M, Steffensen B. Matrix metalloproteinase-2 contributes to cancer cell migration on collagen. Cancer Res 2005;65(1):130-6.
|
12 |
Wang Y, Wu N, Pang B, Tong D, Sun D, Sun H, Zhang C, Sun W, Meng X, Bai J, et al. TRIB1 promotes colorectal cancer cell migration and invasion through activation MMP-2 via FAK/Src and ERK pathways. Oncotarget 2017;8(29):47931.
DOI
|
13 |
Meng XN, Jin Y, Yu Y, Bai J, Liu GY, Zhu J, Zhao YZ, Wang Z, Chen F, Lee KY, et al. Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion. Br J Cancer 2009;101(2):327.
DOI
|
14 |
Wu X, Yang L, Zhang Z, Li Z, Shi J, Li Y, Han S, Gao J, TAng C, Su L, et al. Src promotes cutaneous wound healing by regulating MMP-2 through the ERK pathway. Int J Mol Med 2016;37(3):639-48.
DOI
|
15 |
Reddy KB, Nabha SM, Atanaskova N. Role of MAP kinase in tumor progression and invasion. Cancer Metastasis Rev 2003;22(4):395-403.
DOI
|
16 |
Nakayama K. cAMP-response element-binding protein (CREB) and transcription factors are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1. J Biol Chem 2013;288(31):22584-95.
DOI
|
17 |
Wu B, Crampton SP, Hughes CC. Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity 2007;26(2):227-39.
DOI
|
18 |
Wang C-Z, Yuan C-S. Potential role of ginseng in the treatment of colorectal cancer. Am J Chin Med 2008;36(06):1019-28.
DOI
|
19 |
The cell wall polysaccharide metabolism of the brown alga Ectocarpus siliculosus. Insights into the evolution of extracellular matrix polysaccharides in Eukaryotes. New Phytol 2010;188(1):82-97.
DOI
|
20 |
Broadhead ML, Clark J, Myers DE, Dass CR, Choong PF. The molecular pathogenesis of osteosarcoma: a review. Sarcoma 2011;2011.
|
21 |
Choi HH, Jong HS, Park JH, Choi S, Lee JW, Kim TY, Otsuki T, Namba M, Bang YJ. A novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells. Int J Oncol 2003;23(4):1087-93.
|
22 |
Qu B, Liu BR, Du YJ, Chen J, Cheng YQ, Xu W, Wang XH. -catenin signaling pathway may regulate the expression of angiogenic growth factors in hepatocellular carcinoma. Oncol Lett 2014;7(4):1175-8.
DOI
|
23 |
Lee SY. Synergistic effect of maclurin on ginsenoside compound K induced inhibition of the transcriptional expression of matrix metalloproteinase-1 in HaCaT human keratinocyte cells. J Ginseng Res 2018;42(2):229-32.
DOI
|
24 |
Chen S, Wang Z, Huang Y, O'Barr SA, Wong RA, Yeung S, Chow MS. Ginseng and anticancer drug combination to improve cancer chemotherapy: a critical review. Evid base Compl Alternative Med 2014;2014.
|
25 |
Park JK, Park SH, So K, Bae IH, Yoo YD,Um H-D. ICAM-3 enhances the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt and CREB. Int J Oncol 2010;36(1):181-92.
|
26 |
Porter AG, Janicke RU. Emerging roles of caspase-3 in apoptosis. Cell Death Differ 1999;6(2):99.
DOI
|
27 |
van Zijl F, Krupitza G, Mikulits W. Initial steps of metastasis: cell invasion and endothelial transmigration. Mutat Res Rev Mutat Res 2011;728(1):23-34.
DOI
|
28 |
Kim KM, Im AR, Kim SH, Hyun JW, Chae S. Timosaponin AIII inhibits melanoma cell migration by suppressing COX-2 and in vivo tumor metastasis. Cancer Sci 2016;107(2):181-8.
DOI
|
29 |
Zhang S, Pang H, Sun M, Li H. Timosaponin AIII inhibits the growth of human leukaemia cells HL-60 by down-regulation of PI3K/AKT and -catenin pathways. Biotechnol Biotechnol Equip 2018;32(1):150-5.
DOI
|
30 |
Lowe SW, Lin AW. Apoptosis in cancer. Carcinogenesis 2000;21(3):485-95.
DOI
|
31 |
Kang YJ, Chung HJ, Nam JW, Park HJ, Seo EK, Kim YS, Lee D, Lee SK. Cytotoxic and antineoplastic activity of timosaponin A-III for human colon cancer cells. J Nat Prod 2011;74(4):701-6.
DOI
|
32 |
Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol 2007;35(4):495-516.
DOI
|
33 |
Lakhani SA, Masud A, Kuida K, Porter GA, Booth CJ, Mehal WZ, Inayat I, Flavell RA. Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 2006;311(5762):847-51.
DOI
|
34 |
Boucher D, Blais V, Denault J-B. Caspase-7 uses an exosite to promote poly (ADP ribose) polymerase 1 proteolysis. Proce Natl Acad Sci 2012;109(15):5669-74.
DOI
|
35 |
Ahuja A, Kim JH, Kim J-H, Yi Y-S, Cho JY. Functional role of ginseng-derived compounds in cancer. J Ginseng Res 2017.
|
36 |
Chaitanya GV, Alexander JS, Babu PP. PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration. Cell Commun Signal 2010;8(1):31.
DOI
|