Ginsenoside compound K inhibits nuclear factor-kappa B by targeting Annexin A2 |
Wang, Yu-Shi
(Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, College of Life Science, Jilin University)
Zhu, Hongyan (Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, College of Life Science, Jilin University) Li, He (Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, College of Life Science, Jilin University) Li, Yang (Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, College of Life Science, Jilin University) Zhao, Bing (State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University) Jin, Ying-Hua (Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, College of Life Science, Jilin University) |
1 | Xiao C, Ghosh S. NF-kappaB, an evolutionarily conserved mediator of immune and inflammatory responses. Adv Exp Med Biol 2005;560:41. DOI |
2 | Liu CY, Zhou RX, Sun CK, Jin YH, Yu HS, Zhang TY, Xu LQ, Jin FX. Preparation of minor ginsenosides C-Mc, C-Y, F2, and C-K from American ginseng PPDginsenoside using special ginsenosidase type-I from Aspergillus niger g.848. J Ginseng Res 2015;39(3):221-9. DOI |
3 | Yayeh T, Yun K, Jang S, Oh S. Morphine dependence is attenuated by red ginseng extract and ginsenosides Rh2, Rg3, and compound K. J Ginseng Res 2016;40(4):445-52. DOI |
4 | Upadhyaya J, Kim MJ, Kim YH, Kim YH, Ko SR, Park HW, Kim MK. Enzymatic formation of compound-K from ginsenoside Rb1 by enzyme preparation from cultured mycelia of Armillaria mellea. J Ginseng Res 2016;40(2):105-12. DOI |
5 | Lei C, Yue M, Qi S, Zhongyu Z, Xiaoqing G, Xiaotong S, Guihua T, Hairong C, Yifa Z. Ginsenoside compound K sensitizes human colon cancer cells to TRAILinduced apoptosis via autophagy-dependent and -independent DR5 upregulation. Cell Death Dis 2016;7(8):e2334. DOI |
6 | Sunghee C, Kyungsook C, Junghye C, Donghyun K, Kyungtae L, Compound K. A metabolite of ginseng saponin, induces apoptosis via caspase-8-dependent pathway in HL-60 human leukemia cells. BMC Cancer 2009;9(1):449. DOI |
7 | Shin KO, Seo CH, Cho HH, Oh S, Hong SP, Yoo HS, Hong JT, Oh KW, Lee YM. Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells. Arch Pharm Res 2014;37(9):1183. DOI |
8 | Jeong A, Lee HJ, Jeong SJ, Lee HJ, Lee EO, Bae H, Kim SH. Compound K inhibits basic fibroblast growth factor-induced angiogenesis via regulation of p38 mitogen activated protein kinase and AKT in human umbilical vein endothelial cells. Biol Pharm Bull 2010;33(6):945-50. DOI |
9 | Shin DH, Leem DG, Shin JS, Kim JI, Kim KY, Choi SY, Lee MH, Choi JH, Lee KT. Compound K induced apoptosis via endoplasmic reticulum Ca2+ release through ryanodine receptor in human lung cancer cells. J Ginseng Res 2017. |
10 | Hu C, Song G, Zhang B, Liu Z, Chen R, Zhang H, Hu T. Intestinal metabolite compound K of panaxoside inhibits the growth of gastric carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway. J Cell Mol Med 2012;16(1):96. DOI |
11 | Lee IK, Kang KA, Lim CM, Kim KC, Kin HS, Kim DH, Kim BJ, Chang WY, Choi JH, Hyun JW. Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells. Int J Mol Sci 2010;11(12):4916-31. DOI |
12 | Wang CZ, Zhang Z, Wan JY, Zhang CF, Anderson S, He X, Yu C, He TC, Qi LW, Yuan CS. Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer. Nutrients 2015;7(2):799. DOI |
13 | Campbell KA, Minashima T, Zhang Y, Hadley S, Lee YJ, Giovinazzo J, Quirno M, Jirsch T. Annexin A6 interacts with p65 and stimulates activity and catabolic events in articular chondrocytes. Arthr Rheumatol 2013;65(12):3120. DOI |
14 | Karin M. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol 2009;1(5):a000141. DOI |
15 | Wasmuth HE, Tacke F, Trautwein C. Chemokines in liver inflammation and fibrosis. Front Biosci J Virtual Lib 2002;7(03):d1899. DOI |
16 | Okuda K. Hepatocellular carcinoma. Curr Opin Oncol 2000;32(4):357. |
17 | Wang ZM, Zhu SG, Wu ZW, Lu Y, Fu HZ, Qian RQ. Kirenol upregulates nuclear annexin-1 which interacts with to attenuate synovial inflammation of collagen-induced arthritis in rats. J Ethnopharmacol 2011;137(1):774-82. DOI |
18 | Jeon YJ, Kim DH, Jung H, Chung SJ, Chi SW, Cho S, Lee SC, Park BC, Park SG, Bae KH. Annexin A4 interacts with the NF-kappaB p50 subunit and modulates NF-kappaB transcriptional activity in a Ca2+-dependent manner. Cell Mol Life Sci 2010;67(13):2271. DOI |
19 | Ecsedi P, Kiss B, Gogl G, Radnai L, Buday L, Koprivanacz K, Liliom K, Leveles I, Vertessy B, Jeszen}o N, et al. Regulation of the equilibrium between closed and open conformations of annexin A2 by N-terminal phosphorylation and S100A4-binding. Structure 2017;25(8). 1195-1207.e5. DOI |
20 | Wang YS, Li H, Li Y, Zhu H, Jin YH. Identification of natural compounds targeting Annexin A2 with an anti-cancer effect. Protein Cell 2017. |
21 | Liu P, Kimmoun E, Legrand A, Sauvanet A, Degott C, Lardeux B, Bernuau D. Activation of , AP-1, and STAT transcription factors is a frequent and early event in human hepatocellular carcinomas. J Hepatol 2002;37(1):63-71. DOI |
22 | Bonavida B. RKIP-mediated chemo-immunosensitization of resistant cancer cells via disruption of the /snail/YY1/RKIP resistance-driver loop. Crit Rev Oncog 2014;19(6):431. DOI |
23 | Zhang K, Li Y. Effects of ginsenoside compound K combined with cisplatin on the proliferation, apoptosis and epithelial mesenchymal transition in MCF-7 cells of human breast cancer. Pharm Biol 2015;54(4):1. |
24 | Kang S, Siddiqi MH, Yoon SJ, Ahn S, Noh HY, Kumar NS, Kin YJ, Yang DC. Therapeutic potential of compound K as an IKK inhibitor with implications for osteoarthritis prevention: an in silico and in vitro study. Vitro Cell Develop Biol Anim 2016:1-11. |
25 | Luedde T, Schwabe RF. in the liver-linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol 2011;8(2):108-18. DOI |
26 | Arlt A, Gehrz A, Muerkoster S, Vorndamn J, Kruse ML, Folsch UR, Schafer H. Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene 2003;22(21):3243. DOI |
27 | Ming Y, Chen Z, Chen L, Lin D, Tong Q, Zheng Z, Song G. Ginsenoside compound K attenuates metastatic growth of hepatocellular carcinoma, which is associated with the translocation of nuclear factor-kB p65 and reduction of matrix metalloproteinase-2/9. Planta Med 2010;77(5):428-33. DOI |
28 | Luedde T, Trautwein C. Intracellular survival pathways in the liver. Liver Int 2006;26(10):1163-74. DOI |
29 | Yang WS, Yi YS, Kim D, Kim MH, Park JG, Kim E, Lee SY, Yoon K, Kim JH, Park J, et al. Nuclear factor kappa-B- and activator protein-1-mediated immunostimulatory activity of compound K in monocytes and macrophages. J Ginseng Res 2017;41(3):298-306. DOI |
30 | Choi K, Kim M, Ryu J, Choi C. Ginsenosides compound K and Rh 2, inhibit tumor necrosis factor--induced activation of the and JNK pathways in human astroglial cells. Neurosci Lett 2007;421(1):37. DOI |
31 | Jung H, Kim JS, Kim WK, Oh KJ, Kim JM, Lee HJ, Han BS, Kim DS, Seo YS, Lee SC, et al. Intracellular annexin A2 regulates signaling by binding to the p50 subunit: implications for gemcitabine resistance in pancreatic cancer. Cell Death Dis 2015;6(1):e1606. DOI |
32 | Wang YS, Lin Y, Li H, Li Y, Song ZG, Jin YH. The identification of molecular target of (20S) ginsenoside Rh2 for its anti-cancer activity. Sci Rep 2017. |
33 | Zhang F, Wang Q, Ye L, Feng Y, Zhang X. Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells. J Med Virol 2010;82(6):920-8. DOI |
34 | Lu B, Guo H, Zhao J, Wang C, Wu G, Pang M, Tong X, Bu F, Liang A, Hou S, et al. Increased expression of iASPP, regulated by hepatitis B virus X proteinmediated activation, in hepatocellular carcinoma. Gastroenterology 2010;139(6):2183-94. e5. DOI |