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http://dx.doi.org/10.1016/j.jgr.2017.02.002

Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells  

Choi, Seo-Yun (Department of Food Science and Biotechnology, College of Life Science, CHA University)
Kim, Kui-Jin (Department of Food Science and Biotechnology, College of Life Science, CHA University)
Song, Ji-Hyeon (Department of Food Science and Biotechnology, College of Life Science, CHA University)
Lee, Boo-Yong (Department of Food Science and Biotechnology, College of Life Science, CHA University)
Publication Information
Journal of Ginseng Research / v.42, no.2, 2018 , pp. 225-228 More about this Journal
Abstract
Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These findings also provide a part of molecular rationale for the role of ginsenoside Rg5 as a potent cognitive impairment preventive compound in blocking the initiation of hippocampal damage.
Keywords
cognitive impairment; Ginsenoside Rg5; HT22; neuroprotection; thermal stress;
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