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http://dx.doi.org/10.1016/j.jgr.2016.07.007

Photoprotective effects of topical ginseng leaf extract using Ultraflo L against UVB-induced skin damage in hairless mice  

Hong, Yang Hee (Department of Beauty Art, Suwon Women's University)
Lee, Hyun-Sun (Agency for Korea National Food Cluster)
Jung, Eun Young (Department of Home Economic Education, Jeonju University)
Han, Sung-Hee (Department of Public Health Sciences, Graduate School, Korea University)
Park, Yooheon (Dongguk University Research Institute of Biotechnology and Medical Converged Science)
Suh, Hyung Joo (Department of Public Health Sciences, Graduate School, Korea University)
Publication Information
Journal of Ginseng Research / v.41, no.4, 2017 , pp. 456-462 More about this Journal
Abstract
Background: Abnormal activation of matrix metalloproteinases (MMPs) plays an important role in UV-induced wrinkle formation, which is a major dermatological problem. This formation occurs due to the degeneration of the extracellular matrix (ECM). In this study, we investigated the cutaneous photoprotective effects of Ultraflo L treated ginseng leaf (UTGL) in hairless mice. Methods: SKH-1 hairless mice (6 weeks of age) were randomly divided into four groups (8 mice/group). UTGL formulation was applied topically to the skin of the mice for 10 weeks. The normal control group received nonvehicle and was not irradiated with UVB. The UV control (UVB) group received nonvehicle and was exposed to gradient-UVB irradiation. The groups (GA) receiving topical application of UTGL formulation were subjected to gradient-UVB irradiation on $0.5mg/cm^2$ [GA-low (GA-L)] and $1.0mg/cm^2$ [(GA-high (GA-H)] of dorsal skin area, respectively. Results: We found that topical treatment with UTGL attenuated UVB-induced epidermal thickness and impairment of skin barrier function. Additionally, UTGL suppressed the expression of MMP-2, -3, and -13 induced by UVB irradiation. Our results show that topical application of UTGL protects the skin against UVB-induced damage in hairless mice and suggest that UTGL can act as a potential agent for preventing and/or treating UVB-induced photoaging. Conclusion: UTGL possesses sunscreen properties and may exhibit photochemoprotective activities inside the skin of mice. Therefore, UTGL could be used as a potential therapeutic agent to protect the skin against UVB-induced photoaging.
Keywords
cosmeceutical; ginseng leaf; matrix metalloproteinases; photodamage; Ultraflo L;
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Times Cited By KSCI : 2  (Citation Analysis)
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