Processed Panax ginseng, sun ginseng, inhibits the differentiation and proliferation of 3T3-L1 preadipocytes and fat accumulation in Caenorhabditis elegans |
Lee, Hyejin
(Lab of Cell Differentiation Research, College of Korean Medicine, Gachon University)
Kim, Jinhee (Lab of Cell Differentiation Research, College of Korean Medicine, Gachon University) Park, Jun Yeon (Lab of Cell Differentiation Research, College of Korean Medicine, Gachon University) Kang, Ki Sung (Lab of Cell Differentiation Research, College of Korean Medicine, Gachon University) Park, Joeng Hill (College of Pharmacy, Seoul National University) Hwang, Gwi Seo (Lab of Cell Differentiation Research, College of Korean Medicine, Gachon University) |
1 | Ramsay TG. Fat cells. Endocrinol Metab Clin North Am 1996;25:847-70. DOI |
2 | Lee OH, Lee HH, Kim JH, Lee BY. Effect of ginsenosides Rg3 and Re on glucose transport in mature 3T3-L1 adipocytes. Phytother Res 2011;25:768-73. DOI |
3 | Lee H, Kim J, Lee SY, Park JH, Hwang GS. Processed Panax ginseng, sun ginseng, decreases oxidative damage induced by tert-butyl hydroperoxide via regulation of antioxidant enzyme and anti-apoptotic molecules in HepG2 Cells. J Ginseng Res 2012;36:248-55. DOI |
4 | Song KC, Chang TS, Lee H, Kim J, Park JH, Hwang GS. Processed Panax ginseng, sun ginseng increases Type I collagen by regulating MMP-1 and TIMP-1 expression in human dermal fibroblasts. J Ginseng Res 2012;36:61-7. DOI |
5 | Lee YS, Cha BY, Yamaguchi K, Choi SS, Yonezawa T, Teruya T, Nagai K, Woo JT. Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice. Cytotechnology 2010;62:367-76. DOI |
6 | Kim JH, Hahm DH, Yang DC, Kim JH, Lee HJ, Shim I. Effect of crude saponin of Korean red ginseng on high-fat diet-induced obesity in the rat. J Pharmacol Sci 2005;97:124-31. DOI |
7 |
Huang B, Yuan HD, Kim do Y, Quan HY, Chung SH. Cinnamaldehyde prevents adipocyte differentiation and adipogenesis via regulation of peroxisome proliferator-activated receptor- |
8 | Kang KS, Kim HY, Yamabe N, Nagai R, Yokozawa T. Protective effect of sun ginseng against diabetic renal damage. Biol Pharm Bull 2006;29:1678-84. DOI |
9 | Poulos SP, Dodson MV, Hausman G. Cell line models for differentiation: preadipocytes and adipocytes. Exp Biol Med (Maywood) 2010;235:1185-93. DOI |
10 | An Y, Zhang Y, Li C, Qian Q, He W, Wang T. Inhibitory effects of flavonoids from Abelmoschus manihot flowers on triglyceride accumulation in 3T3-L1 adipocytes. Fitoterapia 2011;82:595-600. DOI |
11 | Hung PF, Wu BT, Chen HC, Chen YH, Chen CL, Wu MH, Liu HC, Lee MJ, Kao YH. Antimitogenic effect of green tea (-)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the ERK and Cdk2 pathways. Am J Physiol Cell Physiol 2005;288:C1094-108. DOI |
12 | Yun HJ, Kim JH, Jeong HY, Ji HH, Nam SW, Lee EW, Kim BW, Kwon HJ. Widdrol blocks 3T3-L1 preadipocytes growth and differentiation due to inhibition of mitotic clonal expansion. J Microbiol Biotechnol 2012;22:806-13. DOI |
13 | Zhang SO, Trimble R, Guo F, Mak HY. Lipid droplets as ubiquitous fat storage organelles in C. elegans. BMC Cell Biol 2010;11:96. DOI |
14 | Berger JP, Akiyama TE, Meinke PT. PPARs: therapeutic targets for metabolic disease. Trends Pharmacol Sci 2005;26:244-51. DOI |
15 | Naowaboot J, Chung CH, Pannangpetch P, Choi R, Kim BH, Lee MY, Kukongviriyapan U. Mulberry leaf extract increases adiponectin in murine 3T3-L1 adipocytes. Nutr Res 2012;32:39-44. DOI |
16 | Lee YK, Lee WS, Hwang JT, Kwon DY, Surh YJ, Park OJ. Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells. J Agric Food Chem 2009;57:305-10. DOI |
17 | Hernandez R, Teruel T, Lorenzo M. Insulin and dexamethasone induce GLUT4 gene expression in foetal brown adipocytes: synergistic effect through CCAAT/enhancer-binding protein alpha. Biochem J 2003;372:617-24. DOI |
18 | Fajas L, Schoonjans K, Gelman L, Kim JB, Najib J, Martin G, Fruchart JC, Briggs M, Spiegelman BM, Auwerx J. Regulation of peroxisome proliferatoractivated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol Cell Biol 1999;19:5495-503. DOI |
19 | Ju JH, Yoon HS, Park HJ, Kim MY, Shin HK, Park KY, Yang JO, Sohn MS, Do MS. Anti-obesity and antioxidative effects of purple sweet potato extract in 3T3-L1 adipocytes in vitro. J Med Food 2011;14:1097-106. DOI |
20 | Xing Y, Yan F, Liu Y, Liu Y, Zhao Y. Matrine inhibits 3T3-L1 preadipocyte differentiation associated with suppression of ERK1/2 phosphorylation. Biochem Biophys Res Commun 2010;396:691-5. DOI |
21 | Xu J, Liao K. Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation. J Biol Chem 2004;279:35914-22. DOI |
22 |
Freise C, Trowitzsch-Kienast W, Erben U, Seehofer D, Kim KY, Zeitz M, Ruehl M, Somasundaram R. (+)-Episesamin inhibits adipogenesis and exerts anti-inflammatory effects in 3T3-L1 (pre)adipocytes by sustained Wnt signaling, down-regulation of |
23 | Lane MD, Tang QQ, Jiang MS. Role of the CCAAT enhancer binding proteins (C/EBPs) in adipocyte differentiation. Biochem Biophys Res Commun 1999;266:677-83. DOI |
24 | Andersson K, Gaudiot N, Ribiere C, Elizalde M, Giudicelli Y, Arner P. A nitric oxide-mediated mechanism regulates lipolysis in human adipose tissue in vivo. Br J Pharmacol 1999;126:1639-45. DOI |
25 | Gaudiot N, Ribiere C, Jaubert AM, Giudicelli Y. Endogenous nitric oxide is implicated in the regulation of lipolysis through antioxidant-related effect. Am J Physiol Cell Physiol 2000;279:C1603-10. DOI |
26 | Hwang JT, Lee MS, Kim HJ, Sung MJ, Kim HY, Kim MS, Kwon DY. Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways. Phytother Res 2009;23:262-6. DOI |
27 | Brenner S. The genetics of Caenorhabditis elegans. Genetics 1974;77:71-94. |
28 | Hirsh D, Oppenheim D, Klass M. Development of the reproductive system of Caenorhabditis elegans. Dev Biol 1976;49:200-19. DOI |
29 | Le Lay S, Lefrere I, Trautwein C, Dugail I, Krief S. Insulin and sterol-regulatory element-binding protein-1c (SREBP-1C) regulation of gene expression in 3T3-L1 adipocytes. Identification of CCAAT/enhancer-binding protein beta as an SREBP-1C target. J Biol Chem 2002;277:35625-34. DOI |
30 | Tang QQ, Otto TC, Lane MD. CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis. Proc Natl Acad Sci U S A 2003;4:850-5. |
31 | Zhang M, Ikeda K, Xu JW, Yamori Y, Gao XM, Zhang BL. Genistein suppresses adipogenesis of 3T3-L1 cells via multiple signal pathways. Phytother Res 2009;23:713-8. DOI |
32 | Wu Z, Bucher NL, Farmer SR. Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoids. Mol Cell Biol 1996;16:4128-36. DOI |
33 | Cho KW, Lee OH, Banz WJ, Moustaid-Moussa N, Shay NF, Kim YC. Daidzein and the daidzein metabolite, equol, enhance adipocyte differentiation and PPARgamma transcriptional activity. J Nutr Biochem 2010;21:841-7. DOI |
34 | Ma X, Zhang H, Yuan L, Jing H, Thacker P, Li D. CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes. Biochem J 2011;439:27-38. DOI |
35 | Cho EJ, Jang MH, Baek SH, Kim HY, Kang KS, Kwon SW, Park JH. The effect of steaming on the free amino acid contents and antioxidant activity of Panax ginseng. Food Chem 2008;107:876-82. DOI |
36 | Kawachi H, Moriya NH, Korai T, Tanaka SY, Watanabe M, Matsui T, Kawada T, Yano H. Nitric oxide suppresses preadipocyte differentiation in 3T3-L1 culture. Mol Cell Biochem 2007;300:61-7. DOI |
37 | Kapur S, Marcotte B, Marette A. Mechanism of adipose tissue iNOS induction in endotoxemia. Am J Physiol 1999;276:E635-41. |
38 | Kim SP, Ha JM, Yun SJ, Kim EK, Chung SW, Hong KW, Kim CD, Bae SS. Transcriptional activation of peroxisome proliferator-activated receptor-gamma requires activation of both protein kinase A and Akt during adipocyte differentiation. Biochem Biophys Res Commun 2010;399:55-9. DOI |
39 | Park SY, Lee JH, Kim KY, Kim EK, Yun SJ, Kim CD, Lee WS, Hong KW. Cilostazol increases 3T3-L1 preadipocyte differentiation with improved glucose uptake associated with activation of peroxisome proliferator-activated receptorgamma transcription. Atherosclerosis 2008;201:258-65. DOI |
40 | Chua BT, Gallego-Ortega D, Ramirez de Molina A, Ullrich A, Lacal JC, Downward J. Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells. Mol Cancer 2009;8:131. DOI |
41 | Kang KS, Yamabe N, Kim HY, Park JH, Yokozawa T. Effects of heat-processed ginseng and its active component ginsenoside 20(S)-Rg3 on the progression of renal damage and dysfunction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats. Biol Pharm Bull 2010;33:1077-81. DOI |
42 | Lee JG, Lee YY, Kim SY, Pyo JS, Yun-Choi HS, Park JH. Platelet antiaggregating activity of ginsenosides isolated from processed ginseng. Pharmazie 2009;64:602-4. |
43 | Park JH, Kim JM, Han SB, Kim NY, Surh YJ, Lee SK, Kim ND, Park MK. A new processed ginseng with fortified activity. Advances in Ginseng Research-Proceedings of the 7th International Symposium on Ginseng. Seoul, Korea: Korean Society of Ginseng; 1998. p. 146-59. |
44 | Park IH, Piao LZ, Kwon SW, Lee YJ, Cho SY, Park MK, Park JH. Cytotoxic dammarane glycosides from processed ginseng. Chem Pharm Bull (Tokyo) 2002;50:538-40. DOI |
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