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http://dx.doi.org/10.1016/j.jgr.2016.02.001

Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2  

Yu, Tao (Department of Genetic Engineering, Sungkyunkwan University)
Yang, Yanyan (Department of Genetic Engineering, Sungkyunkwan University)
Kwak, Yi-Seong (Korean Ginseng Corporation, Central Research Institute)
Song, Gwan Gyu (Division of Rheumatology, Department of Internal Medicine, Korea University Guro Hospital)
Kim, Mi-Yeon (Department of Bioinformatics and Life Science, Soongsil University)
Rhee, Man Hee (College of Veterinary Medicine, Kyungpook National University)
Cho, Jae Youl (Department of Genetic Engineering, Sungkyunkwan University)
Publication Information
Journal of Ginseng Research / v.41, no.2, 2017 , pp. 127-133 More about this Journal
Abstract
Background: Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, anti-inflammatory, antiobesity, and antidiabetic effects. In this study, we investigated the effects of G-Rc on inflammatory responses in vitro and examined the mechanisms of these effects. Methods: The in vitro inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis $factor-{\alpha}/interferon-{\gamma}-treated$ synovial cells, and HEK293 cells transfected with various inducers of inflammation. Results: G-Rc significantly inhibited the expression of macrophage-derived cytokines, such as tumor necrosis $factor-{\alpha}$ and $interleukin-1{\beta}$. G-Rc also markedly suppressed the activation of TANK-binding kinase $1/I{\kappa}B$ kinase ${\varepsilon}/interferon$ regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Conclusion: G-Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase $1/I{\kappa}B$ kinase ${\varepsilon}/interferon$ regulatory factor-3 and p38/ATF-2 signaling.
Keywords
anti-inflammatory activity; ginsenoside Rc; p38; Panax ginseng; TANK-binding kinase 1;
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