Korean Red Ginseng water extract arrests growth of xenografted lymphoma cells |
Park, Jae Gwang
(Department of Genetic Engineering, Sungkyunkwan University)
Son, Young-Jin (Department of Pharmacy, Sunchon National University) Aravinthan, Adithan (Department of Physiology, College of Veterinary Medicine, Chonbuk National University) Kim, Jong-Hoon (Department of Physiology, College of Veterinary Medicine, Chonbuk National University) Cho, Jae Youl (Department of Genetic Engineering, Sungkyunkwan University) |
1 | Mao Q, Zhang PH, Wang Q, Li SL. Ginsenoside F 2 induces apoptosis in humor gastric carcinoma cells through reactive oxygen species-mitochondria pathway and modulation of ASK-1/JNK signaling cascade in vitro and in vivo. Phytomedicine 2014;21:515-22. DOI |
2 | Park JG, Kang WS, Park KT, Park DJ, Aravinthan A, Kim JH, Cho JY. Anticancer effect of joboksansam, Korean wild ginseng germinated from bird feces. J Ginseng Res 2016;40:304-8. DOI |
3 | Jung H, Bae J, Ko SK, Sohn UD. Ultrasonication processed Panax ginseng berry extract induces apoptosis through an intrinsic apoptosis pathway in HepG2 cells. Arch Pharm Res 2016;39:855-62. DOI |
4 | Park TY, Park MH, Shin WC, Rhee MH, Seo DW, Cho JY, Kim HM. Anti-metastatic potential of ginsenoside Rp1, a novel ginsenoside derivative. Biol Pharm Bull 2008;31:1802-5. DOI |
5 | Byeon SE, Lee J, Kim JH, Yang WS, Kwak YS, Kim SY, Choung ES, Rhee MH, Cho JY. Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean Red Ginseng. Mediators Inflamm 2012;2012:732860. |
6 | Du XF, Jiang CZ, Wu CF, Won EK, Choung SY. Synergistic immunostimulating activity of pidotimod and red ginseng acidic polysaccharide against cyclophosphamide-induced immunosuppression. Arch Pharm Res 2008;31:1153-9. DOI |
7 | Wang L, Yao Y, Sang W, Yang X, Ren G. Structural features and immunostimulating effects of three acidic polysaccharides isolated from Panax quinquefolius. Int J Biol Macromol 2015;80:77-86. DOI |
8 | Choi KT. Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer. Acta Pharmacol Sin 2008;29:1109-18. DOI |
9 | Kim SH, Cho SS, Simkhada JR, Lee HJ, Kim SW, Kim TS, Yoo JC. Enhancement of 1,25-dihydroxyvitamin D3- and all-trans retinoic acid-induced HL-60 leukemia cell differentiation by Panax ginseng. Biosci Biotechnol Biochem 2009;73:1048-53. DOI |
10 | Durairaj P, Miller SC. Neoplasm prevention and immuno-enhancement mediated by daily consumption of a proprietary extract from North American ginseng by elderly mice of a cancer-prone strain. Phytother Res 2013;27:1339-44. DOI |
11 | Jo S, Lee H, Kim S, Lee CH, Chung H. Korean Red Ginseng extract induces proliferation to differentiation transition of human acute promyelocytic leukemia cells via MYC-SKP2-CDKN1B axis. J Ethnopharmacol 2013;150:700-7. DOI |
12 | De Bruijn ML, Schumacher TN, Nieland JD, Ploegh HL, Kast WM, Melief CJ. Peptide loading of empty major histocompatibility complex molecules on RMA-S cells allows the induction of primary cytotoxic T lymphocyte responses. Eur J Immunol 1991;21:2963-70. DOI |
13 | Park SE, Park C, Kim SH, Hossain MA, Kim MY, Chung HY, Son WS, Kim GY, Choi YH, Kim ND. Korean Red Ginseng extract induces apoptosis and decreases telomerase activity in human leukemia cells. J Ethnopharmacol 2009;121:304-12. DOI |
14 | Endale M, Park SC, Kim S, Kim SH, Yang Y, Cho JY, Rhee MH. Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF--induced inflammatory mediators production in RAW 264.7 cells. Immunobiology 2013;218:1452-67. DOI |
15 | Piao J, Lee JY, Weon JB, Ma CJ, Ko HJ, Kim DD, Kang WS, Cho HJ. Angelica gigas Nakai and Soluplus-based solid formulations prepared by hot-melting extrusion: Oral absorption enhancing and memory ameliorating effects. PLoS One 2015;10:e0124447. DOI |
16 | Cho JY, Kim AR, Yoo ES, Baik KU, Park MH. Ginsenosides from Panax ginseng differentially regulate lymphocyte proliferation. Planta Med 2002;68:497-500. DOI |
17 | Park JG, Kim SC, Kim YH, Yang WS, Kim Y, Hong S, Kim KH, Yoo BC, Kim SH, Kim JH, et al. Anti-inflammatory and antinociceptive activities of anthraquinone-2-carboxylic acid. Mediators Inflamm 2016;2016:1903849. |
18 | Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nature Rev Cancer 2002;2:489-501. DOI |
19 | Yayeh T, Jung KH, Jeong HY, Park JH, Song YB, Kwak YS, Kang HS, Cho JY, Oh JW, Kim SK. Korean Red Ginseng saponin fraction downregulates proinflammatory mediators in LPS stimulated RAW264. 7 cells and protects mice against endotoxic shock. J Ginseng Res 2012;36:263-9. DOI |
20 | Devarajan E, Sahin AA, Chen JS, Krishnamurthy RR, Aggarwal N, Brun AM, Sapino A, Zhang F, Sharma D, Yang XH. Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance. Oncogene 2002;21:8843-51. DOI |
21 | Merdad A, Karim S, Schulten HJ, Dallol A, Buhmeida A, Al-Thubaity F, Gari MA, Chaudhary AG, Abuzenadah AM, Al-Qahtani MH. Expression of matrix metalloproteinases (MMPs) in primary human breast cancer: MMP-9 as a potential biomarker for cancer invasion and metastasis. Anticancer Res 2014;34:1355-66. |
22 | Wang CZ, Yuan CS. Potential role of ginseng in the treatment of colorectal cancer. Am J Chin Med 2008;36:1019-28. DOI |
23 | Hume DA, Perry VH, Gordon S. Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers. J Cell Biol 1983;97:253-7. DOI |
24 | Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Muller-Hermelink HK, Campo E, Braziel RM, Jaffe ES. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood 2004;103:275-82. DOI |
25 | Lee JJ, Kwon HK, Jung IH, Cho YB, Kim KJ, Kim JL. Anticancer activities of ginseng extract fermented with Phellinus linteus. Mycobiology 2009;37:21-7. DOI |
26 | Lv Q, Rong N, Liu LJ, Xu XL, Liu JT, Jin FX, Wang CM. Antitumoral activity of (20R)- and (20S)-ginsenoside Rh2 on transplanted hepatocellular carcinoma in mice. Planta Med 2016;82:705-11. DOI |
27 | Seo EY, Kim WK. Red ginseng extract reduced metastasis of colon cancer cells in vitro and in vivo. J Ginseng Res 2011;35:315-24. DOI |
28 | Kim SJ, Kim AK. Anti-breast cancer activity of fine black ginseng (Panax ginseng Meyer) and ginsenoside Rg5. J Ginseng Res 2015;39:125-34. DOI |
29 | Xiaoguang C, Hongyan L, Xiaohong L, Zhaodi F, Yan L, Lihua T, Rui H. Cancer chemopreventive and therapeutic activities of red ginseng. J Ethnopharmacol 1998;60:71-8. DOI |
30 | Kim JH, Hahm DH, Yang DC, Kim JH, Lee HJ, Shim I. Effect of crude saponin of Korean Red Ginseng on high-fat diet-induced obesity in the rat. J Pharmacol Sci 2005;97:124-31. DOI |
31 | Nabavi SF, Sureda A, Habtemariam S, Nabavi SM. Ginsenoside Rd and ischemic stroke; a short review of literatures. J Ginseng Res 2015;39:299-303. DOI |
32 | Kang S, Min H. Ginseng, the 'immunity boost': the effects of Panax ginseng on immune system. J Ginseng Res 2012;36:354-68. DOI |
33 | Wang CZ, Cai Y, Anderson S, Yuan CS. Ginseng metabolites on cancer chemoprevention: an angiogenesis link? Diseases 2015;3:193-204. DOI |
34 | Choi K, Choi C. Proapoptotic ginsenosides Compound K and Rh 2 enhance Fas-induced cell death of human astrocytoma cells through distinct apoptotic signaling pathways. Cancer Res Treat 2009;41:36-44. DOI |
35 | Wong VK, Cheung SS, Li T, Jiang ZH, Wang JR, Dong H, Yi XQ, Zhou H, Liu L. Asian ginseng extract inhibits in vitro and in vivo growth of mouse lewis lung carcinoma via modulation of ERK-p53 and NF-kappaB signaling. J Cell Biochem 2010;111:899-910. DOI |
36 | Wang CZ, Anderson S, Du W, He TC, Yuan CS. Red ginseng and cancer treatment. Chin J Nat Med 2016;14:7-16. |
37 | Park JM, Lee HJ, Yoo JH, Ko WJ, Cho JY, Hahm KB. Overview of gastrointestinal cancer prevention in Asia. Best Pract Res Clin Gastroenterol 2015;29:855-67. DOI |
38 | Gao M, Kong Y, Yang G, Gao L, Shi J. Multiple myeloma cancer stem cells. Oncotarget 2016. http://dx.doi.org/10.18632/oncotarget.8154. DOI |
39 | Beyth S, Borovsky Z, Mevorach D, Liebergall M, Gazit Z, Aslan H, Galun E, Rachmilewitz J. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood 2005;105:2214-9. DOI |
40 | Kim HS, Lim JM, Kim JY, Kim Y, Park S, Sohn J. Panaxydol, a component of Panax ginseng, induces apoptosis in cancer cells through EGFR activation and ER stress and inhibits tumor growth in mouse models. Int J Cancer 2016;138:1432-41. DOI |
41 | Kim MY, Yoo BC, Cho JY. Ginsenoside-Rp1-induced apolipoprotein A-1 expression in the LoVo human colon cancer cell line. J Ginseng Res 2014;38:251-5. DOI |
42 | Wang JH, Nao JF, Zhang M, He P. 20 (s)-ginsenoside Rg3 promotes apoptosis in human ovarian cancer HO-8910 cells through PI3K/Akt and XIAP pathways. Tumor Biol 2014;35:11985-94. DOI |