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http://dx.doi.org/10.1016/j.jgr.2015.09.001

Modification of ginsenoside composition in red ginseng (Panax ginseng) by ultrasonication  

Yoon, Sung-hyun (Department of Oriental Medical Food & Nutrition, Semyung University)
Nam, Yun-min (Department of Oriental Medical Food & Nutrition, Semyung University)
Hong, Jeong-tae (Department of Oriental Medical Food & Nutrition, Semyung University)
Kim, Shin-jung (Ginseng Research Center)
Ko, Sung-kwon (Department of Oriental Medical Food & Nutrition, Semyung University)
Publication Information
Journal of Ginseng Research / v.40, no.3, 2016 , pp. 300-303 More about this Journal
Abstract
The result of USRG-12 indicated that ultrasonication-processed ($100^{\circ}C$, 12 h) red ginseng extracts had the highest amount of ginsenosides Rg3 (0.803%), Rg5 (0.167%), and Rk1 (0.175%).
Keywords
ginsenoside Rg3; ginsenoside Rg5; ginsenoside Rk1; red ginseng; ultrasonication;
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1 Nanba T. The encyclopedia of Wakan-Yaku with color pictures. Osaka: Hoikusha; 1980.
2 Lee DC, Lee MO, Kim CY, Clifford DH. Effect of ether, ethanol and aqueous extracts of ginseng on cardiovascular function in dogs. Can J Comp Med 1981;45:182-7.
3 Jie YH, Cammisuli S, Baggiolini M. Immunomodulatory effects of Panax ginseng C.A. Meyer in the mouse. Agents Actions 1984;15:386-91.   DOI
4 Kim YC, Kim SR, Markelonis GJ, Oh TH. Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration. J Neurosci Res 1998;53:426-32.   DOI
5 Joo CN, Koo JD, Kim DS, Lee SJ. Biochemical studies of ginseng saponins. XI. The effects of ginseng saponins on alcohol dehydrogenase. Hanguk Saenghwa Hakhoe Chi 1977;10:109-20.
6 Yokozawa T, Kobayashi T, Oura H, Kawashima Y. Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb2 in streptozotocin-diabetic rats. Chem Pharm Bull (Tokyo) 1985;33:869-72.   DOI
7 Wang W, Zhao Y, Rayburn ER, Hill DL, Wang H, Zhang R. In vitro anticancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemother Pharmacol 2007;59:589-601.   DOI
8 Park JD. Recent studies on the chemical constituents of Korean Ginseng (Panax ginseng C.A. Meyer). Korea J Ginseng Sci 1996;20:389-415.
9 Shibata S, Tanaka O, Ando T, Sado M, Tsushima S, Ohsawa T. Chemical studies on oriental plant drugs. XIV. Protopanaxadiol, a genuine sapogenin of ginseng saponins. Chem Pharm Bull (Tokyo) 1966;14:595-600.   DOI
10 Tanaka O, Nagai M, Shibata S. Chemical studies on the oriental plant drugs. XVI. The stereochemistry of protopanaxadiol, a genuine sapogenin of ginseng. Chem Pharm Bull (Tokyo) 1966;14:1150-6.   DOI
11 Keum YS, Han SS, Chun KS, Park KK, Park JH, Lee SK, Surh YJ. Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion. Mutat Res 2003;523-4:75-85.
12 Keum YS, Park KK, Lee JM, Chun KS, Park JH, Lee SK, Kwon H, Surh YJ. Antioxidant and anti-tumor promoting activities of the methanol extract of heatprocessed ginseng. Cancer Lett 2000;150:41-8.   DOI
13 Kim ND, Kang SY, Park JH, Schini-Kerth VB. Ginsenoside Rg3 mediates endothelium-dependent relaxation in response to ginsenosides in rat aorta: role of K+ channels. Eur J Pharmacol 1999;367:41-9.   DOI
14 Jung KY, Kim DS, Oh SR, Lee IS, Lee JJ, Park JD, Kim SI, Lee HK. Platelet activating factor antagonist activity of ginsenosides. Biol Pharm Bull 1998;21:79-80.   DOI
15 Kwon SW, Han SB, Park IH, Kim JM, Park MK, Park JH. Liquid chromatographic determination of less polar ginsenosides in processed ginseng. J Chromatogr 2001;921:335-9.   DOI
16 Kim SJ, Kim JD, Ko SK. Changes in ginsenoside composition of ginseng berry extracts after a microwave and vinegar process. J Ginseng Res 2013;37:269-72.   DOI
17 Kim ND, Kang SY, Kim MJ, Park JH, Schini-Kerth VB. The ginsenoside Rg3 evokes endothelium-independent relaxation in rat aortic rings: role of K+ channels. Eur J Pharmacol 1999;367:51-7.   DOI
18 Yang L, Hao J, Zhang J, Xia W, Dong X, Hu X, Kong F, Cui X. Ginsenoside Rg3 promotes beta-amyloid peptide degradation by enhancing gene expression of neprilysin. J Pharm Pharmacol 2009;61:375-80.   DOI
19 Lee WM, Kim SD, Park MH, Cho JY, Park HJ, Seo GS, Rhee MH. Inhibitory mechanisms of dihydroginsenoside Rg3 in platelet aggregation: critical roles of ERK2 and cAMP. J Pharm Pharmacol 2008;60:1531-6.   DOI
20 Chu S, Gu J, Feng L, Liu J, Zhang M, Jia X, Liu M, Yao D. Ginsenoside Rg5 improves cognitive dysfunction and beta-amyloid deposition in STZ-induced memory impaired rats via attenuating neuroinflammatory responses. Int Immunopharmacol 2014;19:317-26.   DOI
21 Ko SK, Im BO, editors. The science of Korean ginseng. Seoul: Yakupsinmunsa; 2009.