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http://dx.doi.org/10.1016/j.jgr.2015.08.001

Effect of Korean Red Ginseng extraction conditions on antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content: optimization using response surface methodology  

Lee, Jin Woo (College of Pharmacy, Chungbuk National University)
Mo, Eun Jin (College of Pharmacy, Chungbuk National University)
Choi, Ji Eun (College of Pharmacy, Chungbuk National University)
Jo, Yang Hee (College of Pharmacy, Chungbuk National University)
Jang, Hari (College of Pharmacy, Chungbuk National University)
Jeong, Ji Yeon (College of Pharmacy, Chungbuk National University)
Jin, Qinghao (College of Pharmacy, Chungbuk National University)
Chung, Hee Nam (Dasom Co., Ltd.)
Hwang, Bang Yeon (College of Pharmacy, Chungbuk National University)
Lee, Mi Kyeong (College of Pharmacy, Chungbuk National University)
Publication Information
Journal of Ginseng Research / v.40, no.3, 2016 , pp. 229-236 More about this Journal
Abstract
Background: Extraction conditions greatly affect composition, as well as biological activity. Therefore, optimization is essential for maximum efficacy. Methods: Korean Red Ginseng (KRG) was extracted under different conditions and antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content evaluated. Optimized extraction conditions were suggested using response surface methodology for maximum antioxidant activity and extraction yield. Results: Analysis of KRG extraction conditions using response surface methodology showed a good fit of experimental data as demonstrated by regression analysis. Among extraction factors, such as extraction solvent and extraction time and temperature, ethanol concentration greatly affected antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content. The optimal conditions for maximum antioxidant activity and extraction yield were an ethanol concentration of 48.8%, an extraction time 73.3 min, and an extraction temperature of $90^{\circ}C$. The antioxidant activity and extraction yield under optimal conditions were 43.7% and 23.2% of dried KRG, respectively. Conclusion: Ethanol concentration is an important extraction factor for KRG antioxidant activity and extraction yield. Optimized extraction conditions provide useful economic advantages in KRG development for functional products.
Keywords
antioxidant activity; extraction conditions; extraction yield; optimization; Panax ginseng (Korean Red Ginseng);
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Times Cited By KSCI : 13  (Citation Analysis)
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