Enzymatic formation of compound-K from ginsenoside Rb1 by enzyme preparation from cultured mycelia of Armillaria mellea |
Upadhyaya, Jitendra
(Department of Food Science and Technology, Chonbuk National University)
Kim, Min-Ji (Department of Food Science and Technology, Chonbuk National University) Kim, Young-Hoi (Department of Food Science and Technology, Chonbuk National University) Ko, Sung-Ryong (Bureau of General Affairs, The Korean Society of Ginseng) Park, Hee-Won (Korea Ginseng Corporation Research Institute, Korea Ginseng Corporation) Kim, Myung-Kon (Department of Food Science and Technology, Chonbuk National University) |
1 | Christensene LP. Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 2009;55:1-99. |
2 | Liu CY, Song JG, Li PF, Yu HS, Jin FX. Ginsenoside contents in three different ginseng. J Dalian Polytechnic Univ 2011;30:79-82. |
3 | Xu QF, Fang XL, Chen DF. Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats. J Ethnopharmacol 2005;84:187-92. |
4 | Yu K, Chen F, Li C. Absorption, disposition, and pharmacokinetics of saponins from Chinese medicinal herbs: what do we know and what do we need to know more? Curr Drug Metab 2012;13:577-98. DOI |
5 | Hasegawa H. Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid. J Pharmacol Sci 2004;95:153-7. DOI |
6 | Kato T, Kida T, Kanaoka M, Hattori M, Kobashi K. Drug metabolism: intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol 1998;50:1155-60. DOI |
7 | Lee BH, Lee SJ, Hui JH, Lee SY, Sung JH, Huh JD, Moon CK. In vitro antigenotoxic activity of novel ginseng saponin metabolites formed by intestinal bacteria. Planta Med 1998;64:500-3. DOI |
8 | Bae EA, Choo MK, Park SY, Shin SY, Kim DH. Metabolism of ginsenoside Rc by human intestinal bacteria and its related antiallergic activity. Biol Pharm Bull 2002;25:743-7. DOI |
9 | Nag SA, Qin JJ, Wang W, Wang MH, Wang H, Zhang R. Ginsenosides as anticancer agents: in vitro and in vivo activities, structureeactivity relationships, and molecular mechanisms of action. Front Pharmacol 2012;3:1-18. |
10 | Li HU, Bae EA, Han MJ, Kim DH. Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury. Liver Int 2005;25:1069-73. DOI |
11 | Park JS, Shin JA, Jung JS, Hyun JW, Van Le TKV, Kim DH, Park EM, Kim HS. Antiinflammatory mechanism of compound K in activated microglia and its neuroprotective effect on experimental stroke in mice. J Pharmacol Exp 2012;341:59-67. DOI |
12 | Faber K. Advantages and disadvantages of biocatalysts. In: Biotransformation in organic chemistry. 3rd ed. Berlin: Springer-Verlag; 1997. |
13 | Han BH, Park MH, Han YN, Woo LK, Sankawa U, Yahara S, Tanaka O. Degradation of ginseng saponins under mild acid condition. Planta Med 1982;44:146-9. DOI |
14 | Chen YJ, Nose M, Ogihara Y. Alkaline cleavage of ginsenosides. Chem Pharm Bull 1987;35:1653-5. DOI |
15 | Yang XD, Yang YU, Ouyang DS, Yang GP. A review of biotransformation and pharmacology of ginsenoside compound K. Fitoterapia 2015;100:208-20. DOI |
16 | Bae SH, Lee HS, Kim MR, Kim SY, Kim JM, Suh HJ. Changes of ginsenoside content by mushroom mycelial fermentation in red ginseng extract. J Ginseng Res 2011;35:235-42. DOI |
17 | Ryu JS, Lee HJ, Bae SH, Kim SY, Park YH, Suh HJ. The bioavailability of red ginseng extract of fermented by Phellinus linteus. J Ginseng Res 2013;37:108-16. DOI |
18 | By Hsu, Lu TJ, Chen CH, Wang SJ, Hwang LS. Biotransformation of ginsenoside Rd in the ginseng extraction residue by fermentation with lingzhi (Ganoderma lucidum). Food Chem 2013;141:4186-93. DOI |
19 | Gao LW, Li WY, Zhao YL, Wang JW. The cultivation, bioactive components and pharmacological effects of Armillaria mellea. Afr J Biotechnol 2009;8:7383-440. |
20 | Lung MY, Chang YC. Antioxidant properties of the edible basidiomycete Armillaria mellea in submerged cultures. Int J Mol Sci 2011;12:6367-84. DOI |
21 | Chen YJ, Wue SY, Chen CC, Tsaog YL, Hsu NC, Chou YC, Huang HL. Armillaria mellea component armillarikin induces apoptosis in human leukemia cells. J Funct Foods 2014;6:196-204. DOI |
22 |
Mfombep PM, Senwo ZN, Isikhuemhen OS. Enzymatic activities and kinetic properties of |
23 | Sanada S, Kondo N, Shoji J, Tanaka O, Shibata S. Studies on the saponins of ginseng. I. Structures of ginsenoside-Ro, -Rb1, -Rb2, -Rc, and -Rd. Chem Pharm Bull 1974;22:421-8. DOI |
24 | Buswell JA, Cai YJ, Chang ST, Peberdy JF, Fu SY, Yu HS. Lignocellulolytic enzyme profiles of edible mushroom fungi. World J Microbiol Biotechnol 1996;12:537-42. DOI |
25 | Baldrian P, Valaskova V. Degradation of cellulose by basiomycetous fungi. FEBS Microbiol Rev 2008;32:501-21. DOI |
26 | Sun BS, Xu MY, Li Z, Wang BW, Sung CK. UPLC-Q-TOF-MS/MS analysis for steaming times-dependent profiling of steamed Panax quinquefolius and its ginsenosides transformations induced by repetitious steaming. J Ginseng Res 2012;36:277-90. DOI |
27 |
Luan H, Liu X, Qi X, Hu Y, Hao D, Cui Y, Yang L. Purification and haracterization of a novel stable ginsenoside Rb1-hydrolyzing |
28 |
Zhao X, Gao L, Wang J, Bi H, Gao J, Du X, Zhou Y, Tai G. A novel ginsenoside Rb1-hydrolyzing |
29 | Park CS, Yoo MH, Noh KH, Oh DK. Biotransformation of ginsenosides by hydrolyzing the sugar moieties of ginsenosides using microbial glycosidases. Appl Microbiol Biotechnol 2010;87:9-19. DOI |
30 | Quan LH, Cheng LQ, Kim HB, Kim JH, Son NR, Kim SY, Jin HO, Yang DC. Bioconversion of ginsenoside Rd into compound K by Lactobacillus pentosus DC101 isolated from Kimchi. J Ginseng Res 2010;34:288-95. DOI |
31 | Park SY, Bae EA, Sung JH, Lee SK, Kim DH. Purification and characterization of ginsenoside Rb1-metabolizing beta-glucosidase from Fusobacterium K-60, a human intestinal anaerobic bacterium. Biosci Biotechnol Biochem 2001;65:1163-9. DOI |
32 | Zhou W, Yan Q, Li JY, Zhang XC, Zhou P. Biotransformation of Panax notoginseng saponins into ginsenoside compound K production by Paecilomyces bainier sp. 229. J Appl Microbiol 2008;104:699-706. DOI |
![]() |